DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CarT and Slc22a30

DIOPT Version :9

Sequence 1:	NP_610052.1	Gene:	CarT / 35334	FlyBaseID:	FBgn0032879	Length:	674	Species:	Drosophila melanogaster
Sequence 2:	NP_795976.1	Gene:	Slc22a30 / 319800	MGIID:	2442750	Length:	552	Species:	Mus musculus

Alignment Length:	555	Identity:	140/555 - (25%)
Similarity:	249/555 - (44%)	Gaps:	43/555 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 DLLPTIGEFGKYQ------KLLVFGICLP--------ACIPCGFCAFNQLFMADTPDDYWCRIPE 88
            :||..:|..|::|      .|.:.|:.:|        |.||...| :..:...||..|...||
Mouse     5 ELLNQVGSLGRFQILQISFVLFLVGLVVPHITMENFTAAIPNHRC-WAPILDNDTASDNGSRI-- 66

  Fly    89 LLDLPLEQRKSLSIPKELDNDELVYSKCYTYG-VNWTQLLESGEEDDLTTMEPNASWPLIKCPQG 152
                 |.|...|.|...||:: |...||..:. ..|..|..:|...:.|  ||:..    .|..|
Mouse    67 -----LSQDDLLRISIPLDSN-LRLDKCRRFAQPQWHLLHLNGTFSNET--EPDTE----PCVDG 119

  Fly   153 WEYNTSVVWSSIVIDFDLVCDQDIYPTIGLAALNTGGPVGVYLFGLLNDRGGRRLSYFVCLATLL 217
            |.|:.|...|:||.::||||:.....::...:...|..:|..:.|.|:||.||:   |:....||
Mouse   120 WVYDRSNFLSTIVTEWDLVCESQALNSVAKFSFMIGLFIGAIICGHLSDRFGRK---FILTCALL 181

  Fly   218 AGSL---MTSLSKDFWTWAGSRVIVGLTIPAVYQIPFIISLELVGENYRSFVTVMTCTFYTSGIM 279
            ..::   ..:.:..|:.:...|.:.|:::..:.....::.||.....:...|.|:|....:.|.|
Mouse   182 QFAITETCVAFAPSFFIYCLLRFLAGMSVEPISVNSHLLMLEWTSPKFLGMVAVLTSCAASIGYM 246

  Fly   280 LLSGVTYLERDWVRLSYITSLPFYAYFLYMFVMPESPRWLLMRGRLEEALKILERMAKVNG-REF 343
            :|:|:.:|.|.|..|....|:|.:.:.:....|.||.|||::..:.::.||.|.::|.:|| :..
Mouse   247 ILAGLAFLFRIWRHLQLAMSVPIFFFLILTRWMSESARWLIVTNKPQKGLKELRKVAHMNGMKNS 311

  Fly   344 PEAVHLKLEAQIRRDKLKKQKKKMANVGLADLCRTPNMRLKTILITLSWFANETVYLGLSYYGPA 408
            ...:.:::.....:::|:..|:|.:.   .||..||.:|.:..:::...:.......|||.:...
Mouse   312 GNTLTMEVVEASMKNELEAAKRKSSP---RDLFHTPILRKRICVLSFMRYLFTISIFGLSLHLQH 373

  Fly   409 LGTNQYVSFFLSAVVELPSYLCCWYFMDTWGRRWPLSLSMILGGVACVITVMLPDDAVDETLVLY 473
            |.||..:..|||:.:.:...:...:.::..|||....:.|.|.|:..:..|.:|.:.....:::.
Mouse   374 LSTNIILLQFLSSALGILISVIGHFVLNHMGRRITQLVLMSLRGIFMLTAVFVPQEMQTLRIIMA 438

  Fly   474 LVSKALLSASFLIIYPFAGELYPTQVRGIGIGASSYIGGLGLIGIPFITYLGKDNLKLPLVIMGF 538
            .::.||.|....:......||.||.:|..|:|..:..|..||...|....|...:..||.:..|.
Mouse   439 TLAAALSSLCMCVSNLHINELLPTTLRATGMGVIAMFGNSGLFLAPLFMLLATYSANLPWIFYGG 503

  Fly   539 LSMLGGMTGLRLPETLHHRLPQTIEEGEEFGKNWQ 573
            .|:|.|.:...||||.:..||.:|   .:.|.:|:
Mouse   504 FSILYGFSVFLLPETKNQPLPDSI---HDVGNDWK 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CarT	NP_610052.1	2A0119	44..561	CDD:273328	135/535 (25%)
CarT	NP_610052.1	MFS	182..551	CDD:119392	87/372 (23%)
Slc22a30	NP_795976.1	2A0119	11..525	CDD:273328	134/534 (25%)
Slc22a30	NP_795976.1	MFS	151..516	CDD:119392	87/370 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	74	1.000	Domainoid score	I9078
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.010