DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CarT and Slc22a13

DIOPT Version :9

Sequence 1:	NP_610052.1	Gene:	CarT / 35334	FlyBaseID:	FBgn0032879	Length:	674	Species:	Drosophila melanogaster
Sequence 2:	NP_001119757.1	Gene:	Slc22a13 / 316062	RGDID:	1306840	Length:	551	Species:	Rattus norvegicus

Alignment Length:	594	Identity:	166/594 - (27%)
Similarity:	271/594 - (45%)	Gaps:	80/594 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 LLPTIGEFGKYQKLLVFGICLPACIPCGFCAFNQLFMADTPDDYWCRIP----ELLDLPLEQRKS 99
            ::..:|:||::|..|...:.:|..: ..|..|:|:||. ..:.::|.:.    ...:|...::.:
  Rat     7 VMAEVGDFGRFQVRLTILMGIPNFL-SAFFVFSQVFMV-LDEAHYCSVSWVKNHTFNLSAAEQLA 69

  Fly   100 LSIPKELDNDELVYSKCYTYGVNWTQLLESGEEDDLTTMEP---NASWPLI---------KCPQG 152
            :|||    ||                  .:|..:......|   |||...|         .|..|
  Rat    70 VSIP----ND------------------TAGRPESCLMFRPPPDNASLEDILSHRFNETQACDSG 112

  Fly   153 WEYNTSVVWSSIVIDFDLVCDQDIYPTIGLAALNTGGPVGVYLFGLLNDRGGRRLSYFVCLATLL 217
            |:|..:.. .|:..:|||||:::.......:....|..||..:||.:.|..|||.|..:.|  ||
  Rat   113 WDYPENRP-PSLKNEFDLVCERENLKRTSQSVFMAGLLVGALVFGPVCDWIGRRPSLLMQL--LL 174

  Fly   218 AG--SLMTSLSKDFWTWAGSRVIVGLTIPAVYQIPFIIS-----LELVGENYRSFVTVMTCTFYT 275
            :|  |:.|:....|..:...|..:     |.....|::|     .|.||.:.|:...|:..:.:.
  Rat   175 SGIASMATAFVSSFELYMTLRFAL-----ATANAGFLLSSNVLLSEWVGTSRRTRAMVLAQSNFA 234

  Fly   276 SGIMLLSGVTYLERDWVRLSYITSLPFYAYFLYMFVMPESPRWLLMRGRLEEALKILERMAKVNG 340
            .|:|.|:|:.|..|:|..|..|.:.|.:....|.:|:||||||||.:||.|||.:::::.|.|||
  Rat   235 LGLMALAGLAYGVRNWRLLQIIGTTPIFLLVFYFWVLPESPRWLLSQGRTEEAKQLVQKAALVNG 299

  Fly   341 REFPEAVHLKLEAQIRRDKLKKQKKKMANVGLADLCRTPNMRLKTILITLSWFANETVYLGLSYY 405
            |  |.|..|       .::|..:|...:...| ||.|.|.:|..|:::...||.:..:|.||.:.
  Rat   300 R--PLASEL-------LNQLVPEKTGPSGNAL-DLFRHPQLRKVTLILIAVWFVDSLLYYGLGFQ 354

  Fly   406 GPALGTNQYVSFFLSAVVELPSYLCCWYFMDTWGRRWPLSLSMILGGVACVITVMLPDDAVDETL 470
            ....|.:.|::..:..|||:|:.|.....|:..||:|....::.|.||.|||.:.:|.|......
  Rat   355 VGDFGLDIYLTQVIFGVVEVPARLSSIPMMEKLGRKWSQLCTLTLAGVMCVIIIFIPGDLPTVAT 419

  Fly   471 VLYLVSKALLSASFLIIYPFAGELYPTQVRGIGIGASSYIGGLGLIGIPFITYLGKDNLKLPLVI 535
            .|.:|.|...||:|.|.|.:..||.||.:|..|:|..|....:|.|..|.:..|.:.:..:|::|
  Rat   420 ALAVVGKFASSAAFTISYVYTAELLPTIIRQTGMGLVSIFSRVGGIITPLVMLLEQYHKAIPMLI 484

  Fly   536 MGFLSMLGGMTGLRLPETLHHRLPQTIEEGEEFGKNWQFKDCCRCAQKPEILSQPASYENLDVLA 600
            .|.|.:..|:....||||....|..|:::.|:             .|.|.  |...:.:..||.|
  Rat   485 FGSLPIGAGLLCALLPETRGQTLKDTLQDLEQ-------------GQPPR--SYKTAPQRKDVEA 534

  Fly   601 GSSTNASEV 609
            ...|:::.|
  Rat   535 SGRTSSARV 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CarT	NP_610052.1	2A0119	44..561	CDD:273328	156/539 (29%)
CarT	NP_610052.1	MFS	182..551	CDD:119392	117/375 (31%)
Slc22a13	NP_001119757.1	2A0119	12..510	CDD:273328	156/539 (29%)
Slc22a13	NP_001119757.1	MFS	139..500	CDD:119392	117/377 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.020