DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CarT and Slc22a15

DIOPT Version :9

Sequence 1:	NP_610052.1	Gene:	CarT / 35334	FlyBaseID:	FBgn0032879	Length:	674	Species:	Drosophila melanogaster
Sequence 2:	NP_001101177.1	Gene:	Slc22a15 / 310732	RGDID:	1311184	Length:	548	Species:	Rattus norvegicus

Alignment Length:	565	Identity:	155/565 - (27%)
Similarity:	246/565 - (43%)	Gaps:	87/565 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 VDEAFDLDDLLPTIGEFGKYQKLLVFGICLPACIPCGFCAFNQLFMAD----------TPDDYWC 84
            |:|||.      .:||.|.||..|.|.:.:          ..||::|.          ||..:|
  Rat     3 VEEAFQ------AVGEMGLYQMYLCFLLAV----------LLQLYVATEAILIALIGATPAYHW- 50

  Fly    85 RIPELLDLPLEQRKSLSIPKELDNDELVYSKCYTYGVNWTQLLESGEEDDLTTMEPNASWPLIKC 149
            .:.||  ||.:...:.|           ..|...:| :|. |..:|.|........|:
  Rat    51 DMAEL--LPNQSHSNQS-----------SGKGQAFG-DWL-LTANGSEIHKHVHFSNS------- 93

  Fly   150 PQGWEYNTSVVWSSIVIDFDLVCDQDIYPTIGLAALNTGGPVGVYLFGLLNDRGGRRLSYFVCLA 214
                       ::||..::.|:.::....:...:...:|..|||..||.|:||.||:..|....|
  Rat    94 -----------FTSIASEWFLIANRSYKVSAASSFFFSGVFVGVISFGQLSDRFGRKKVYLTGFA 147

  Fly   215 TLLAGSLMTSLSKDFWTWAGSRVIVGLTIPAVYQIPFIISLELVGENYRSFVTVMTCTFYTSGIM 279
            ..:..::....|..:..:|.:|.:||:....:..:.|::..|.||..|.:....:...|:..||.
  Rat   148 LDILFAIANGFSPSYEFFAVTRFLVGMMNGGMSLVAFVLLNECVGAAYWALAGSIGGLFFAVGIA 212

  Fly   280 LLSGVTYLERDWVRLSYITSLPFYAYFLYMFVMPESPRWLLMRGRLEEALKILERMAKVNGREFP 344
            ..:.:.|..|.|..|:.:.:|.....||....:|||||||..:|||.||.:.|..:||.|.:
  Rat   213 QYALLGYFIRSWRTLAILVNLQGTVVFLLSLFIPESPRWLYSQGRLSEAEEALYLIAKRNRK--- 274

  Fly   345 EAVHLKLEAQIRRDKLKKQKKKMANVGLADLCRTPNMRLKTILITLSWFANETVYLGLSYYGPAL 409
                ||....:.....:..::   .....||.|...:...|:::...||....||.||:.....|
  Rat   275 ----LKCTFSLTHPANRSYRE---TGSFLDLFRYRVLLGHTLILMFIWFVCSLVYYGLTLSAGDL 332

  Fly   410 GTNQYVSFFLSAVVELPSY-LCCWYFMDTW-GRRWPLSLSMILGGVACVITVMLPDD------AV 466
            |.:.|.:..||.::|:||| ||.:.....| ||:..|:..:.|||:||:|.:.||:.      ||
  Rat   333 GGSIYANLALSGLIEIPSYPLCIYLINQRWFGRKRTLAAFLCLGGLACLIVMFLPEKKDTGVFAV 397

  Fly   467 DETLVLYLVSKALLSASFLIIYPFAGELYPTQVRGIGIGASSYIGGLGLIGIPFITYLGKDNLKL 531
            ..:..|.|:.|..:||:|.|:|.:..|||||.:|.:|:|..|....:|.|..||:..|......|
  Rat   398 VNSHSLSLLGKLTISAAFNIVYIYTSELYPTVIRNVGLGTCSMFSRVGGIIAPFVPSLKDVQWSL 462

  Fly   532 PLVIMGFLSMLGGMTGLRLPETLHHRLPQTIEE---------GEE 567
            |.::.|...:..|:..|.|||||:..|.:|..:         |||
  Rat   463 PFIVFGATGLTSGLLSLLLPETLNSPLLETFSDLQMYSYRRLGEE 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CarT	NP_610052.1	2A0119	44..561	CDD:273328	147/534 (28%)
CarT	NP_610052.1	MFS	182..551	CDD:119392	113/376 (30%)
Slc22a15	NP_001101177.1	MFS	111..469	CDD:119392	110/367 (30%)
Slc22a15	NP_001101177.1	MFS_1	111..450	CDD:284993	105/348 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920