DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CarT and Slc22a6

DIOPT Version :9

Sequence 1:	NP_610052.1	Gene:	CarT / 35334	FlyBaseID:	FBgn0032879	Length:	674	Species:	Drosophila melanogaster
Sequence 2:	NP_058920.1	Gene:	Slc22a6 / 29509	RGDID:	69338	Length:	551	Species:	Rattus norvegicus

Alignment Length:	539	Identity:	144/539 - (26%)
Similarity:	258/539 - (47%)	Gaps:	35/539 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 DDLLPTIGEFGKYQKLLVFGICLPACIPCGFCAFNQL--FMADTPDDYWCRIPELLDLPLEQRKS 99
            :|||..:|..|::|.:.|..:..|..:   ..:.|.|  |.|..|..: ||.|...:|..:....
  Rat     4 NDLLKQVGGVGRFQLIQVTMVVAPLLL---MASHNTLQNFTAAIPPHH-CRPPANANLSKDGGLE 64

  Fly   100 LSIPKELDNDELVYSKCYTY-GVNWTQLLESGEEDDLTTM-EPNASWPLIKCPQGWEYNTSVVWS 162
            ..:|.:.....   ..|..: ...|.....:|.|.:.|.: ||        |..||.|:.|...|
  Rat    65 AWLPLDKQGQP---ESCLRFTSPQWGPPFYNGTEANGTRVTEP--------CIDGWVYDNSTFPS 118

  Fly   163 SIVIDFDLVCDQDIYPTIGLAALNTGGPVGVYLFGLLNDRGGRR----LSYFVCLATLLAGSLMT 223
            :||.:::|||....:..:..:....|..:|..:||.|.||.|||    |:|   |.|.::|: ..
  Rat   119 TIVTEWNLVCSHRAFRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNY---LQTAVSGT-CA 179

  Fly   224 SLSKDFWTWAGSRVIVGLTIPAVYQIPFIISLELVGENYRSFVTVMTCTFYTSGIMLLSGVTYLE 288
            :.:.::..:...|::.|:::.::......:::|.:..:.|::|..:....|:.|..||:|:.|..
  Rat   180 AYAPNYTVYCVFRLLSGMSLASIAINCMTLNVEWMPIHTRAYVGTLIGYVYSLGQFLLAGIAYAV 244

  Fly   289 RDWVRLSYITSLPFYAYFLYMFVMPESPRWLLMRGRLEEALKILERMAKVNGREFPEAVHLKLEA 353
            ..|..|..:.|:||:..|:|.:...||.||....|||:..|:.|:|:|::||::...|   ||..
  Rat   245 PHWRHLQLVVSVPFFIAFIYSWFFIESARWYSSSGRLDLTLRALQRVARINGKQEEGA---KLSI 306

  Fly   354 QIRRDKLKKQ---KKKMANVGLADLCRTPNMRLKTILITLSWFANETVYLGLSYYGPALGTNQYV 415
            ::.|..|:|:   .|..|:.  .:|.|.|.:|...:.:::.|||....|.||.......|.:.|:
  Rat   307 EVLRTSLQKELTLSKGQASA--MELLRCPTLRHLFLCLSMLWFATSFAYYGLVMDLQGFGVSMYL 369

  Fly   416 SFFLSAVVELPSYLCCWYFMDTWGRRWPLSLSMILGGVACVITVMLPDDAVDETLVLYLVSKALL 480
            ...:...|:||:...|:..:::.|||.....|::|.|:..::..::|.........|.::.|..|
  Rat   370 IQVIFGAVDLPAKFVCFLVINSMGRRPAQMASLLLAGICILVNGIIPKSHTIIRTSLAVLGKGCL 434

  Fly   481 SASFLIIYPFAGELYPTQVRGIGIGASSYIGGLGLIGIPFITYLGKDNLKLPLVIMGFLSMLGGM 545
            ::||..|:.:.||||||.:|..|:|..|.:..:|.|..|.::...:....:||.|.|.:.::...
  Rat   435 ASSFNCIFLYTGELYPTVIRQTGLGMGSTMARVGSIVSPLVSMTAEFYPSMPLFIFGAVPVVASA 499

  Fly   546 TGLRLPETLHHRLPQTIEE 564
            ....|||||...||.|:::
  Rat   500 VTALLPETLGQPLPDTVQD 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CarT	NP_610052.1	2A0119	44..561	CDD:273328	140/527 (27%)
CarT	NP_610052.1	MFS	182..551	CDD:119392	100/375 (27%)
Slc22a6	NP_058920.1	2A0119	11..515	CDD:273328	140/527 (27%)
		MFS	135..505	CDD:119392	100/378 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	514..551		1/5 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.020