DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CarT and Slc22a3

DIOPT Version :9

Sequence 1:	NP_610052.1	Gene:	CarT / 35334	FlyBaseID:	FBgn0032879	Length:	674	Species:	Drosophila melanogaster
Sequence 2:	NP_062103.1	Gene:	Slc22a3 / 29504	RGDID:	3701	Length:	551	Species:	Rattus norvegicus

Alignment Length:	575	Identity:	185/575 - (32%)
Similarity:	279/575 - (48%)	Gaps:	59/575 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 PSVDEAFDLDDLLPTIGEFGKYQKLLVFGICLPACIPCGFCAFNQLFMADTPDDYWCRIPELLDL 92
            |:.|:|      |...||||::|:.:...:||.. :...|.....:|:...||.||||.|....|
  Rat     2 PTFDQA------LRKAGEFGRFQRRVFLLLCLTG-VTFAFLFVGVVFLGSQPDYYWCRGPRATAL 59

  Fly    93 -------PLEQ----RKSLSIPKELDNDELVYSKCYTYGVNWTQLLESGEEDDLTTME------- 139
                   |.|:    ...|.:|.|....    ..|:.|      ||    ||..|:.|
  Rat    60 AERCAWSPEEEWNLTTPELHVPAERRGQ----GHCHRY------LL----EDTNTSSELSCDPLA 110

  Fly   140 --PNASWPLIKCPQGWEYNTSVVWSSIVIDFDLVCDQDIYPTIGLAALNTGGPVGVYLFGLLNDR 202
              ||.|.||:.|...|.|..:  .|:||..|||||.......:..|.||.|...|.:..|...||
  Rat   111 AFPNRSAPLVPCSGDWRYVET--HSTIVSQFDLVCGNAWMLDLTQAILNLGFLAGAFTLGYAADR 173

  Fly   203 GGRRLSYFV-CLATLLAGSLMTSLSKDFWTWAGSRVIVGLTIPAVYQIPFIISLELVGENYRSFV 266
            .||.:.|.: |....:.| ::.:.:.:|..:...|.:.|:.....:...|:|..|:||...|..|
  Rat   174 YGRLIVYLISCFGVGITG-VVVAFAPNFSVFVIFRFLQGVFGKGAWMTCFVIVTEIVGSKQRRIV 237

  Fly   267 TVMTCTFYTSGIMLLSGVTYLERDWVRLSYITSLPFYAYFLYMFVMPESPRWLLMRGRLEEALKI 331
            .::...|:|.||::|.|:.|....|..:....|||.:.:.||.:|:|||||||:.|.:.|:||:|
  Rat   238 GIVIQMFFTLGIIILPGIAYFTPSWQGIQLAISLPSFLFLLYYWVVPESPRWLITRKQGEKALQI 302

  Fly   332 LERMAKVNGREFPEAVHLKLEAQIRRDKLKKQKKKMANVGLADLCRTPNMRLKTILITLSWFANE 396
            |.|:||.||:      ||    .....::....::::|....||.|||.||..|:::..:||.:.
  Rat   303 LRRVAKCNGK------HL----SSNYSEITVTDEEVSNPSCLDLVRTPQMRKCTLILMFAWFTSA 357

  Fly   397 TVYLGLSYYGPALGTNQYVSFFLSAVVELPSYLCCWYFMDTWGRRWPLSLSMILGGVACVITVML 461
            .||.||......:|.|.|:.||:|.:||||..|.....::..|||.|.:.|.|:.||:|::|..|
  Rat   358 VVYQGLVMRLGLIGGNLYMDFFISGLVELPGALLILLTIERLGRRLPFAASNIVAGVSCLVTAFL 422

  Fly   462 PDDAVDETLVLYLVSKALLSASFLIIYPFAGELYPTQVRGIGIGASSYIGGLGLIGIPFITY-LG 525
            |:........:..:.:..::.:|.|:|....|||||.:|..|:...|.:...|.|..||:.: |.
  Rat   423 PEGIPWLRTTVATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSLCSGLCDFGGIIAPFLLFRLA 487

  Fly   526 KDNLKLPLVIMGFL-SMLGGMTGLRLPETLHHRLPQTIEEGEEFGKNWQFKDCCR 579
            ...|:|||:|.|.| |:.||:..| ||||....||:|:|:.|:.|.: |...|.|
  Rat   488 AIWLELPLIIFGILASVCGGLVML-LPETKGIALPETVEDVEKLGSS-QLHQCGR 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CarT	NP_610052.1	2A0119	44..561	CDD:273328	174/539 (32%)
CarT	NP_610052.1	MFS	182..551	CDD:119392	122/371 (33%)
Slc22a3	NP_062103.1	2A0119	12..523	CDD:273328	174/539 (32%)
Slc22a3	NP_062103.1	MFS	145..513	CDD:119392	122/379 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	1	1.000	-	-		mtm12320
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.920