DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CarT and Slc22a2

DIOPT Version :9

Sequence 1:	NP_610052.1	Gene:	CarT / 35334	FlyBaseID:	FBgn0032879	Length:	674	Species:	Drosophila melanogaster
Sequence 2:	NP_113772.1	Gene:	Slc22a2 / 29503	RGDID:	61936	Length:	593	Species:	Rattus norvegicus

Alignment Length:	625	Identity:	190/625 - (30%)
Similarity:	307/625 - (49%)	Gaps:	84/625 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 LDDLLPTIGEFGKYQKLLVFGICLPACIPCGFCAFNQL-----FMADTPDDYWCRIPELLDLPLE 95
            :||:|..||||..:||...|.:.|.:      .||..:     |:..|||.: |..|..  ..|.
  Rat     4 VDDILEHIGEFHLFQKQTFFLLALLS------GAFTPIYVGIVFLGFTPDHH-CWSPGA--AKLS 59

  Fly    96 QRKSLSIPKELD--------NDELVY-SKCYTYGVNWTQLLESGEEDDLTTMEPNAS-------W 144
            ||...|..:||:        :||..: |:|..|.|:|.|       ..|..::|.:|       .
  Rat    60 QRCGWSQAEELNYTVPGLGPSDEASFLSQCMRYEVDWNQ-------STLDCVDPLSSLAADRNQL 117

  Fly   145 PLIKCPQGWEYNTSVVWSSIVIDFDLVCDQ----DIYPTIGLAALNTGGPVGVYLFGLLNDRGGR 205
            ||..|..||.|||.  .||||.:|:|||..    |::.::    :|.|..:|..:.|.|.||.||
  Rat   118 PLGPCEHGWVYNTP--GSSIVTEFNLVCAHSWMLDLFQSV----VNVGFFIGAMMIGYLADRFGR 176

  Fly   206 RLSYFVCLATLL----AGSLMTSLSKDFWTWAGSRVIVGLTIPAVYQIPFIISLELVGENYRSFV 266
            :   |..|.|:|    :|:|| ::|.::......|.:.||...|.:.|.:|:..|.||..||..|
  Rat   177 K---FCLLVTILINAISGALM-AISPNYAWMLVFRFLQGLVSKAGWLIGYILITEFVGLGYRRMV 237

  Fly   267 TVMTCTFYTSGIMLLSGVTYLERDWVRLSYITSLPFYAYFLYMFVMPESPRWLLMRGRLEEALKI 331
            .:.....:|.|:::|:||.|:..:|..|.:..:||.:.:.||.:.:|||||||:.:.::.:|:||
  Rat   238 GICYQIAFTVGLLILAGVAYVIPNWRWLQFAVTLPNFCFLLYFWCIPESPRWLISQNKIVKAMKI 302

  Fly   332 LERMAKVNGREFPEAVHLKLEAQIRRDKLKKQKKKMANVGLADLCRTPNMRLKTILITLSWFANE 396
            ::.:||.||:..|.::......:....|||.        .:.||.|||.:|..|:::..:||.:.
  Rat   303 IKHIAKKNGKSVPVSLQNLTPDEDAGKKLKP--------SILDLVRTPQIRKHTLILMYNWFTSS 359

  Fly   397 TVYLGLSYYGPALGTNQYVSFFLSAVVELPSYLCCWYFMDTWGRRWPLSLSMILGGVACVITVML 461
            .:|.||..:....|.|.|:.||.||:||.|:.......:|..|||:|.::|.::.|.||:.:|.:
  Rat   360 VLYQGLIMHMGLAGDNIYLDFFYSALVEFPAAFIIILTIDRVGRRYPWAVSNMVAGAACLASVFI 424

  Fly   462 PDDAVDETLVLYLVSKALLSASFLIIYPFAGELYPTQVRGIGIGASSYIGGLGLIGIPFITYLGK 526
            |||.....:.:..:.:..::.::.::.....|||||.:|.:|:...|.:..:|.|..||:.|...
  Rat   425 PDDLQWLKITIACLGRMGITMAYEMVCLVNAELYPTYIRNLGVLVCSSMCDIGGIITPFLVYRLT 489

  Fly   527 DN-LKLPLVIMGFLSMLGGMTGLRLPETLHHRLPQTIEEGEEFGKNWQFKDCCRCAQK------- 583
            |. ::.|||:...:.::.|...|.||||....||:|||:.|    |.|     |..:|
  Rat   490 DIWMEFPLVVFAVVGLVAGALVLLLPETKGKALPETIEDAE----NMQ-----RPRKKERKENLP 545

  Fly   584 PEILSQP-ASYENLDVLAGSSTNASEVELELRDSRRVREP 622
            |...|:| |..:...::|..:..|..   |.||...:..|
  Rat   546 PSQASRPSAKLKRKGIIAAGADFALS---EARDGASLSPP 582

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CarT	NP_610052.1	2A0119	44..561	CDD:273328	168/546 (31%)
CarT	NP_610052.1	MFS	182..551	CDD:119392	113/373 (30%)
Slc22a2	NP_113772.1	2A0119	12..525	CDD:273328	168/546 (31%)
Slc22a2	NP_113772.1	MFS	125..492	CDD:119392	122/384 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	1	1.000	-	-		mtm12320
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.920