DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CarT and SLC22A24

DIOPT Version :9

Sequence 1:	NP_610052.1	Gene:	CarT / 35334	FlyBaseID:	FBgn0032879	Length:	674	Species:	Drosophila melanogaster
Sequence 2:	NP_001129978.2	Gene:	SLC22A24 / 283238	HGNCID:	28542	Length:	552	Species:	Homo sapiens

Alignment Length:	579	Identity:	167/579 - (28%)
Similarity:	252/579 - (43%)	Gaps:	73/579 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 DDLLPTIGEFGKYQKLLVFGICLPACIPCGFCAFNQL---------FMADTPDDYWCRIPELLD- 91
            |.||..:|..|::|      |||.|.    ||..|.|         |.|.|| .:.|.:| |||
Human     4 DVLLDQVGGMGRFQ------ICLIAF----FCITNILLFPNIVLENFTAFTP-SHRCWVP-LLDN 56

  Fly    92 ----------LPLEQRKSLSIPKELDNDELVYSKCYTYGVNWTQLLESGEEDDLTTMEPNASWPL 146
                      |..:....:|||  ||:: |...||..:.....|||.      |....||.:.|.
Human    57 DTVSDNDTGTLSKDDLLRISIP--LDSN-LRPQKCQRFIHPQWQLLH------LNGTFPNTNEPD 112

  Fly   147 IK-CPQGWEYNTSVVWSSIVIDFDLVCDQDIYPTIGLAALNTGGPVGVYLFGLLNDRGGRRLSYF 210
            .: |..||.|:.|...|:||.::||||:.....::..:....|..:|..::|.|:||.||::...
Human   113 TEPCVDGWVYDRSSFLSTIVTEWDLVCESQSLKSMVQSLFMAGSLLGGLIYGHLSDRVGRKIICK 177

  Fly   211 VCLATLLAGSLMTSLSKDFWTWAGSRVIVGLTIPAVYQIPFIISLELVGENYRSF-VTVMTCTFY 274
            :|...|...:...:.:..|..:...|.:.|.:...:....||:|||......||. :.|:.|: |
Human   178 LCFLQLAISNTCAAFAPTFLVYCILRFLAGFSTMTILGNTFILSLEWTLPRSRSMTIMVLLCS-Y 241

  Fly   275 TSGIMLLSGVTYLERDWVRLSYITSLPFYAYFLYMFVMPESPRWLLMRGRLEEALKILERMAKVN 339
            :.|.|||.|:.:..:||..|....|.|....||..:.|.||.|||::..:|:|.||.|.|:|.:|
Human   242 SVGQMLLGGLAFAIQDWHILQLTVSTPIIVLFLSSWKMVESARWLIINNQLDEGLKELRRVAHIN 306

  Fly   340 GREFPEAVHLKLEAQIRRDKLKKQKKKM-ANVGLADLCRTPNMRLKTILITLSWFANETVYLGLS 403
            |::..|..   |..::.|..:||:...: ....:..|.|.|.:|::...:....||....:.||.
Human   307 GKKNTEET---LTTELVRSTMKKELDAVRIKTSIFSLFRAPKLRMRVFGLCFVRFAITVPFYGLI 368

  Fly   404 YYGPALGTNQYVSFF--LSAVVELPSYLCCWYFMDTWGRRWPLSLSMIL----GGVACVITVMLP 462
            .....||:|  ||.|  |...|...:.......::..|||    :|.||    .|:..::...||
Human   369 LNLQHLGSN--VSLFQILCGAVTFTARCVSLLTLNHMGRR----ISQILFTFPVGLFILVNTFLP 427

  Fly   463 DD-----AVDETLVLYLVSKALLSASFLIIYPFAGELYPTQVRGIGIGASSYIGGLGLIGIPFIT 522
            .:     .|..||.:..||.|..|||.     ...||.||.:|....|.::..|..|....|.:.
Human   428 QEMQILRVVLATLGIGSVSAASNSASV-----HHNELVPTILRSTVAGINAVSGRTGAALAPLLM 487

  Fly   523 YLGKDNLKLPLVIMGFLSMLGGMTGLRLPETLHHRLPQTIEEGE---EFGKNWQFKDCC 578
            .|...:..||.:..|...:|.....|.||||....||.||::.|   :..:|.:.:|.|
Human   488 TLMAYSPHLPWISYGVFPILAVPVILLLPETRDLPLPNTIQDVENDRKDSRNIKQEDTC 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CarT	NP_610052.1	2A0119	44..561	CDD:273328	158/550 (29%)
CarT	NP_610052.1	MFS	182..551	CDD:119392	104/381 (27%)
SLC22A24	NP_001129978.2	MFS_OAT	109..516	CDD:340932	117/421 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	5.020