DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CarT and Slc22a1

DIOPT Version :9

Sequence 1:	NP_610052.1	Gene:	CarT / 35334	FlyBaseID:	FBgn0032879	Length:	674	Species:	Drosophila melanogaster
Sequence 2:	NP_036829.1	Gene:	Slc22a1 / 24904	RGDID:	3224	Length:	556	Species:	Rattus norvegicus

Alignment Length:	563	Identity:	177/563 - (31%)
Similarity:	283/563 - (50%)	Gaps:	60/563 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 LDDLLPTIGEFGKYQKLLVFGICL----PACIPCGFCAFNQLFMADTPDDYWCRIPELLDLPLEQ 96
            :||:|..:||||.:||.....:||    .|.|..|.     :|:..||..| |:.|.:.:  |.|
  Rat     4 VDDVLEQVGEFGWFQKQAFLLLCLISASLAPIYVGI-----VFLGFTPGHY-CQNPGVAE--LSQ 60

  Fly    97 RKSLSIPKELD--------NDELVY-SKCYTYGVNWTQ-LLESGEEDDLTTMEPNAS-WPLIKCP 150
            |...|..:||:        :||..: |:|..|.|:|.| .|:.  .|.|:::..|.| .||..|.
  Rat    61 RCGWSQAEELNYTVPGLGPSDEASFLSQCMRYEVDWNQSTLDC--VDPLSSLVANRSQLPLGPCE 123

  Fly   151 QGWEYNTSVVWSSIVIDFDLVCDQDIYPTIGLAALNTGGPVGVYLFGLLNDRGGRRLSYFVCLAT 215
            .||.|:|.  .||||.:|:|||.......:..:.:|.|..:|..:.|.:.||.||:|...|....
  Rat   124 HGWVYDTP--GSSIVTEFNLVCGDAWKVDLFQSCVNLGFFLGSLVVGYIADRFGRKLCLLVTTLV 186

  Fly   216 LLAGSLMTSLSKDFWTWAGSRVIVGLTIPAVYQIPFIISLELVGENYRSFVTVMTCTFYTSGIML 280
            .....::|:::.|:.:....|::.|:.....:...:.:..|.||..||....::....:|.|::.
  Rat   187 TSVSGVLTAVAPDYTSMLLFRLLQGMVSKGSWVSGYTLITEFVGSGYRRTTAILYQMAFTVGLVG 251

  Fly   281 LSGVTYLERDWVRLSYITSLPFYAYFLYMFVMPESPRWLLMRGRLEEALKILERMAKVNGREFPE 345
            |:||.|...||..|....|||.:.:.||.:.:||||||||.:.|...|::|:|::|:.||:..|
  Rat   252 LAGVAYAIPDWRWLQLAVSLPTFLFLLYYWFVPESPRWLLSQKRTTRAVRIMEQIAQKNGKVPP- 315

  Fly   346 AVHLKLEAQIRRDKLKKQKKKMANVGLADLCRTPNMRLKTILITLSWFANETVYLGLSYYGPALG 410
                   |.::...|::...:..:...|||.||||:|..|:::...||:...:|.||..:..|.|
  Rat   316 -------ADLKMLCLEEDASEKRSPSFADLFRTPNLRKHTVILMYLWFSCAVLYQGLIMHVGATG 373

  Fly   411 TNQYVSFFLSAVVELPSYLCCWYFMDTWGRRWPLSLSMILGGVACVITVMLPDD----------- 464
            .|.|:.||.|::||.|:.......:|..||.:|::.|.::.|.||::.:.:|.:
  Rat   374 ANLYLDFFYSSLVEFPAAFIILVTIDRIGRIYPIAASNLVTGAACLLMIFIPHELHWLNVTLACL 438

  Fly   465 -AVDETLVLYLVSKALLSASFLIIYPFAGELYPTQVRGIGIGASSYIGGLGLIGIPFITY-LGKD 527
             .:..|:||.:|  .|::|          |||||.:|.:|:...|.:..||.|..||:.: |.:.
  Rat   439 GRMGATIVLQMV--CLVNA----------ELYPTFIRNLGMMVCSALCDLGGIFTPFMVFRLMEV 491

  Fly   528 NLKLPLVIMGFLSMLGGMTGLRLPETLHHRLPQTIEEGEEFGK 570
            ...|||::.|.|.:..|...|.||||....||:||||.|..|:
  Rat   492 WQALPLILFGVLGLTAGAMTLLLPETKGVALPETIEEAENLGR 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CarT	NP_610052.1	2A0119	44..561	CDD:273328	168/544 (31%)
CarT	NP_610052.1	MFS	182..551	CDD:119392	111/381 (29%)
Slc22a1	NP_036829.1	2A0119	12..525	CDD:273328	168/544 (31%)
Slc22a1	NP_036829.1	MFS	125..515	CDD:119392	123/411 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	1	1.000	-	-		mtm12320
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.920