DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CarT and Slc22a29

DIOPT Version :9

Sequence 1:	NP_610052.1	Gene:	CarT / 35334	FlyBaseID:	FBgn0032879	Length:	674	Species:	Drosophila melanogaster
Sequence 2:	NP_766364.1	Gene:	Slc22a29 / 236293	MGIID:	3605624	Length:	551	Species:	Mus musculus

Alignment Length:	560	Identity:	135/560 - (24%)
Similarity:	243/560 - (43%)	Gaps:	54/560 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 DLLPTIGEFGKYQKL-LVF-----GICLP--------ACIPCGFCAFNQLFMADTPDDYWCRIPE 88
            :||..:|..|::|.| :||     .|.:|        |.||...| :..:...||..|...||
Mouse     5 ELLNQVGSLGRFQILQIVFLFLLNAIVVPHIGMENFTAAIPNHRC-WVPILDNDTASDNGSRI-- 66

  Fly    89 LLDLPLEQRKSLSIPKELDNDELVYSKCYTYG-VNWTQLLESGEEDDLTTMEPNASWPLIKCPQG 152
                 |.|...|.|...||:: |...||..:. ..|..|..:|...:::  ||:..    .|..|
Mouse    67 -----LSQDDLLRISIPLDSN-LRLDKCRRFAQPQWHLLHLNGTFSNVS--EPDTE----PCVDG 119

  Fly   153 WEYNTSVVWSSIVIDFDLVCDQDIYPTIGLAALNTGGPVGVYLFGLLNDRGGRRLSYFVCLATLL 217
            |.|:.|...|:||.::||||:.....::...:...|..:|..:.|.|:||.||:   |:....||
Mouse   120 WVYDRSNFLSTIVTEWDLVCESQALNSVTKFSFMIGLFIGGIICGHLSDRFGRK---FILTCALL 181

  Fly   218 AGSL---MTSLSKDFWTWAGSRVIVGLTIPAVYQIPFIISLELVGENYRSFVTVMTCTFYTSGIM 279
            ..::   ..:.:..|:.:...|.:.|:::..:.....::.||.....:.:.:.|::......|.|
Mouse   182 QFAITETCVAFAPSFFIYCSLRFLAGMSVEPISVNSHLLMLEWTSPKFLAMMAVLSSCAPNIGFM 246

  Fly   280 LLSGVTYLERDWVRLSYITSLPFYAYFLYMFVMPESPRWLLMRGRLEEALKILERMAKVNGRE-- 342
            :|:|:.:|.|.|..|....|.|.:.:.:....:.||.|||::..:.::.||.|.::|.:||.:
Mouse   247 ILAGLAFLFRIWHHLQLTMSAPIFFFLILTRWLSESARWLILINKPQKGLKELRKVAHMNGMKNS 311

  Fly   343 ---FPEAVHLKLEAQIRRDKLKKQKKKMANVGLADLCRTPNMRLKTILITLSWFANETVYLGLSY 404
               ..|.|...::|::...|.|.        .|.||..|..:|.:..:::..........:||:.
Mouse   312 GDLTMEIVRTSMKAELEAAKTKP--------SLRDLFHTSILRKRICVLSFIRLFFTVSIIGLAV 368

  Fly   405 YGPALGTN-QYVSFFLSAVVELPSYLCCWYFMDTWGRRWPLSLSMILGGVACVITVMLPDDAVDE 468
            :...|.:| ..:.|.:||:..|.|.:.. :.::..|||....:.|.|.|:..:|.|.:|.:....
Mouse   369 HLQHLSSNIILLQFLISALAILVSVIGP-FVLNHIGRRITYLVLMSLRGIFIMIAVFVPQEMQTL 432

  Fly   469 TLVLYLVSKALLSASFLIIYPFAGELYPTQVRGIGIGASSYIGGLGLIGIPFITYLGKDNLKLPL 533
            .:::..::..:.|....:.:....||.||.:|...:|...:.|..||...|....:......||.
Mouse   433 RIIMATLAGGISSLCVGVSHLHTNELLPTTLRATALGVIGFFGNSGLFLSPLFMLVATYYANLPW 497

  Fly   534 VIMGFLSMLGGMTGLRLPETLHHRLPQTIEEGEEFGKNWQ 573
            :..|..|:....|...||||.:..||   :...:.|.:|:
Mouse   498 IFYGGFSIFNAFTVFLLPETKNQPLP---DSTHDVGNDWK 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CarT	NP_610052.1	2A0119	44..561	CDD:273328	131/540 (24%)
CarT	NP_610052.1	MFS	182..551	CDD:119392	82/377 (22%)
Slc22a29	NP_766364.1	MFS_OAT	109..515	CDD:340932	96/423 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	74	1.000	Domainoid score	I9078
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.010