DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CarT and Slc22a26

DIOPT Version :9

Sequence 1:	NP_610052.1	Gene:	CarT / 35334	FlyBaseID:	FBgn0032879	Length:	674	Species:	Drosophila melanogaster
Sequence 2:	XP_017173677.1	Gene:	Slc22a26 / 236149	MGIID:	2385316	Length:	553	Species:	Mus musculus

Alignment Length:	554	Identity:	141/554 - (25%)
Similarity:	257/554 - (46%)	Gaps:	51/554 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 DLLPTIGEFGKYQ--KLLVFGIC----LPACIPCGFCAFN-------QLFMADTPDDYWCRIPEL 89
            |||..:|..|::|  ::....||    :|..|...|.|.|       .:...||..:....|
Mouse     5 DLLNLVGSHGRFQILQMAFLLICNVITMPHVILENFTAANLGHRCWVHIIDNDTNSNNNSGI--- 66

  Fly    90 LDLPLEQRKSLSIPKELDNDELVYSKCYTY-GVNWTQLLESGEEDDLTTMEPNASWPLIKCPQGW 153
                |.|...|.|...||:: |...||..: ...|..|..:|...::|  ||:..    .|..||
Mouse    67 ----LSQDDLLRISIPLDSN-LRPEKCRRFVQPQWHLLQFNGSFSNMT--EPDTE----PCMDGW 120

  Fly   154 EYNTSVVWSSIVIDFDLVCDQDIYPTIGLAALNTGGPVGVYLFGLLNDRGGRRLSYFVCLATLLA 218
            .|:.....|:.|.:::|||......::.......|...|.::.|.|:|:.||:|.:...|..:..
Mouse   121 VYDQRTFLSTTVTEWNLVCGSQELNSVAKFIFLIGVLAGHFVGGHLSDKFGRKLLFRCALLQMAI 185

  Fly   219 GSLMTSLSKDFWTWAGSRVIVGLTIPAVYQIPFIISLELVGENYRSFVTVMTCTFYTSGIMLLSG 283
            ....|:|:..|:.:...|.:.||.|..:.....::.||......::.||.::.:.:..|.::|:|
Mouse   186 TGTCTALAPTFFIYCLLRFLTGLCIIPINTNSVLLMLEWTSPKTQALVTTLSMSSHHFGGLILAG 250

  Fly   284 VTYLERDWVRLSYITSLPFYAYFLYMFVMP------ESPRWLLMRGRLEEALKILERMAKVNG-R 341
            :.:..::|..|....|:|     :::.::|      ||.|||::..:.::||:.|.::|..|| :
Mouse   251 LAFAFQNWHHLQLAISVP-----IFVLLIPTSRWLTESARWLIVTNKPQKALQELRKVASKNGIK 310

  Fly   342 EFPEAVHLKLEAQIRRDKLKKQKKKMANVGLADLCRTPNMRLKTILITLSWFANETVYLGLSYYG 406
            ...:.:.:::...|.:|::...:.|.:   |.||...||:|.:..|:.|..|...:..:|::...
Mouse   311 NSEDVLTMEVVRTIMKDEIAIPRTKPS---LRDLFHMPNLRKRLCLLCLLRFLQISPTVGINMNL 372

  Fly   407 PALGTNQYVSFFLSAVVELPSYLCCWYFMDTWGRRWPLSLSMILGGVACVITVMLPDDAVDETLV 471
            ..|..|.:::..|::...:|:.....:.::..|||....|..:|.|:..:..|.:|.:.  :||:
Mouse   373 QHLKGNVFLTQSLTSAFSIPATALGGFLLNYIGRRISQLLPCLLFGIFLLSIVSVPQEM--QTLL 435

  Fly   472 LYLVSKALLSASFLIIYP----FAGELYPTQVRGIGIGASSYIGGLGLIGIPFITYLGKDNLKLP 532
            :.|::  |...|..:||.    ::.||.||.:|...:|.....||:|....|.|..|...:..||
Mouse   436 VVLIT--LAGGSSAMIYNSNVLYSSELMPTVIRATALGVIGICGGVGAALSPLIMILTLYSASLP 498

  Fly   533 LVIMGFLSMLGGMTGLRLPETLHHRLPQTIEEGE 566
            .:|.|.||:|||:..|.||||.:..||.:|::.|
Mouse   499 WIIYGVLSILGGLLPLILPETKNQPLPDSIQDVE 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CarT	NP_610052.1	2A0119	44..561	CDD:273328	136/541 (25%)
CarT	NP_610052.1	MFS	182..551	CDD:119392	93/379 (25%)
Slc22a26	XP_017173677.1	MFS	109..506	CDD:391944	99/414 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.010