Protein Alignment CarT and SV2C

DIOPT Version :10

• Sequence 1: NP_610052.1
• Gene: CarT / 35334
• FlyBaseID: FBgn0032879
• Length: 674
• Species: Drosophila melanogaster
• Sequence 2: NP_055794.3
• Gene: SV2C / 22987
• HGNCID: 30670
• Length: 727
• Species: Homo sapiens
• Alignment Length: 757
• Identity: 148/757 - (19%)
• Similarity: 231/757 - (30%)
• Gaps: 294/757 - (38%)

  Fly     5 EDNDGDEYDELSEL--RQRHKPESQPSVDEAFDLDDLLPTIGEFGKYQKLLVFGICLPACIPCGF 67
            ::.|.|:|....|.  .:.:..|......|..|.||   .|.| |:||               |.
Human    51 DEEDDDDYYPAGETYNGEANDDEGSSEATEGHDEDD---EIYE-GEYQ---------------GI 96

  Fly    68 CAFNQ----LFMADTP--DDYWCRIPELLDLPLEQRKSLSIPKELDND------ELVYSKCYTYG 120
            .:.||    :.....|  |:|            :.|:.|...:..|.:      ||:..:|....
Human    97 PSMNQAKDSIVSVGQPKGDEY------------KDRRELESERRADEEELAQQYELIIQECGHGR 149

  Fly   121 VNWT-------QLLESG------------EEDDLTTMEPNASWPLIKCPQGWEYNTSVVWSSIVI 166
            ..|.       .|:..|            .|.||..  ||:.       .||       ..|||.
Human   150 FQWALFFVLGMALMADGVEVFVVGFVLPSAETDLCI--PNSG-------SGW-------LGSIVY 198

  Fly   167 DFDLVCDQDIYPTIGLAALNTGGPVGVYLFGLLNDRGGRRLSYFVCLATLLAGSLMTSLSKDFWT 231
                                .|..||.:.:|.|.|:.||:.|..:|::.....:.::|..:.:..
Human   199 --------------------LGMMVGAFFWGGLADKVGRKQSLLICMSVNGFFAFLSSFVQGYGF 243

  Fly   232 WAGSRVIVGLTIPAVYQIPFIISLELVGENYRSFVTVMTCTFYTSGIMLLS-------------- 282
            :...|::.|..|.......|....|::....|.......|.|:..|.:..|
Human   244 FLFCRLLSGFGIGGAIPTVFSYFAEVLAREKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGWSF 308

  Fly   283 --GVTYLERDWVRLSYITSLPFYAYFLYMFVMPESPRWLLMRGRLEEALKILERMAKVN--GREF 343
              |..|....|.....:.:||..:..:.:..||||||:||..|:.:||..||:.:...|  .|..
Human   309 SMGSAYQFHSWRVFVIVCALPCVSSVVALTFMPESPRFLLEVGKHDEAWMILKLIHDTNMRARGQ 373

  Fly   344 PEAV----HLKLEAQIRRDKL---------------KKQKKKMANVGLADL-CRTPNMRLKTILI 388
            ||.|    .:|...||  |:|               .:.:.::..:.|..: |....:|..||.:
Human   374 PEKVFTVNKIKTPKQI--DELIEIESDTGTWYRRCFVRIRTELYGIWLTFMRCFNYPVRDNTIKL 436

  Fly   389 TLSWFANETVYLGLSYYGP-----------ALGT-----NQYVSF-------------------- 417
            |:.||.....|.|||.:.|           ||.|     ::|.:|
Human   437 TIVWFTLSFGYYGLSVWFPDVIKPLQSDEYALLTRNVERDKYANFTINFTMENQIHTGMEYDNGR 501

  Fly   418 ----------------------------------------------------------------- 417
                                                                             
Human   502 FIGVKFKSVTFKDSVFKSCTFEDVTSVNTYFKNCTFIDTVFDNTDFEPYKFIDSEFKNCSFFHNK 566

  Fly   418 --------------------FLSAVVELPSYLCCWYFMDTWGRRWPLSLSMILGGVACVI----- 457
                                ||..:..||..:.....||..||...|..||:|.|::|..
Human   567 TGCQITFDDDYSAYWIYFVNFLGTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISCFFLWFGT 631

  Fly   458 --TVMLPDDAVDETLVLY--LVSKALLSASFLIIYPFAGELYPTQVRGIGIG-------ASSYIG 511
              ::|:      ..|.||  |...|..|...:.:     |||||..|..|.|       |::.:|
Human   632 SESMMI------GMLCLYNGLTISAWNSLDVVTV-----ELYPTDRRATGFGFLNALCKAAAVLG 685

  Fly   512 GLGLIGIPFITYLGKDNLKLPLVIMGFLSMLGGMTGLRLPET 553
            .|....:..||      ..:|:::...:.:.||:.||.||:|
Human   686 NLIFGSLVSIT------KSIPILLASTVLVCGGLVGLCLPDT 721

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CarT	NP_610052.1	MFS_SLC22	152..551	CDD:340875	111/573 (19%)
		xylE	<306..>342	CDD:182225	14/37 (38%)
SV2C	NP_055794.3	synapt_SV2	1..727	CDD:130366	148/757 (20%)
		Interaction with SYT1. /evidence=ECO:0000250	1..57		1/5 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	24..84		6/32 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	109..128		5/30 (17%)
		(Microbial infection) C.botulinum neurotoxin type A-binding. /evidence=ECO:0000269|PubMed:27294781	519..563		0/43 (0%)