DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CarT and Slc22a22

DIOPT Version :9

Sequence 1:	NP_610052.1	Gene:	CarT / 35334	FlyBaseID:	FBgn0032879	Length:	674	Species:	Drosophila melanogaster
Sequence 2:	XP_036015188.1	Gene:	Slc22a22 / 210463	MGIID:	2446114	Length:	587	Species:	Mus musculus

Alignment Length:	618	Identity:	141/618 - (22%)
Similarity:	253/618 - (40%)	Gaps:	122/618 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 DLDDLLPTIGEFGKYQKLLVFGICL--------------------PACIPCGFCAFNQLFMADTP 79
            |.|::|..:|:.|::|      ||:                    .|.||...|:.|.
Mouse     2 DFDEILHHVGDSGRFQ------ICMIILLNILSLVLSPHDVLENFTAAIPAHHCSINL------- 53

  Fly    80 DDYWCRIPELLDLPLEQRKSLSIPKELDNDELVYSKCYTYGVNWTQLLESG----EEDDLTTMEP 140
            |:....:...::|..|....:|||...:...   .:|..:.....|.|:|.    ...:|.| ||
Mouse    54 DNSRSEVSTDMNLTTEDLMKVSIPMGPNQKP---EQCRRFRYTQWQFLDSNISTFNSTELET-EP 114

  Fly   141 NASWPLIKCPQGWEYNTSVVWSSIVID---------------------------------FDLVC 172
                    |..||.|:.||..|:||.:                                 :||||
Mouse   115 --------CLDGWTYDHSVFTSTIVTEGLSPPQPWDSDQYYHTKHEISPCEEGLKSSVKVWDLVC 171

  Fly   173 DQDIYPTIGLAALNTGGPVGVYLFGLLNDRGGRRLSYFVCLATLLAGSLMT--SLSKDFWTWAGS 235
            |...:.....|....|..|...|.|:::||.||:.....|  :|..|::.|  :.:.:|..:...
Mouse   172 DFQSFKYYAQATSLAGHLVSCPLSGIISDRFGRKPLLMYC--SLAYGAVGTYCAFAPNFSVYCVL 234

  Fly   236 RVIVGLTIPAVYQIPFIISLELVGENYRSFVTVMTCTFYTSGIMLLSGVTYLERDWVRLSYITSL 300
            |.::......:.....|:.||.....:...:.|::..|.:.|..:|.|:.|:..||..|....:|
Mouse   235 RFLLSAFQSTILINSLILVLEEASVQWHPTIIVLSGLFNSIGQGVLGGLAYVISDWHLLQLAYAL 299

  Fly   301 PFYAYFLYMFVMPESPRWLLMRGRLEEALKILERMAKVNGREFPEAVHLKLEAQIRRDKLKKQKK 365
            ||:.:|:....:|||.|||::.|:.::|.|.|:|:|.:||:   :.:...|..:..|.||||...
Mouse   300 PFFIFFVLFCWVPESVRWLIITGKTDQAWKELQRIASINGK---KGIAQNLTTEDLRSKLKKDVN 361

  Fly   366 KMANV-GLADLCRTPNMRLKTILITLS-WFANETVYLGLSYYGPALGTNQYVSFFLSAVVELPSY 428
            ....: .:.|:...|.:| |.:|...| .||....::||......||.|.:::......:::||.
Mouse   362 STGKLFRIKDIFINPLIR-KIVLSNSSLLFAELFSFVGLLLDVQLLGKNMFLTQIFLGAIDVPSK 425

  Fly   429 LCCWYFMDTWGRRWPLSLSMILGGVACV-ITVMLPDDAVDETLVLYLVSKALLSASFLIIYPFAG 492
            ...::.:....|| ||...::|...:|: ||:.:.::......:::::.|...:|...|...:..
Mouse   426 SLTYFTIRNVSRR-PLIAFLLLTTGSCITITIFISEEMYVLRTIIFILGKGCFAAFTCISTTYIN 489

  Fly   493 ELYPTQVR----GIGIGASSYIGGLGLIGIPFITYLGKDNLKLPLVIMGFLSMLGGMTGLRLPET 553
            ||.|.::|    |:.:......|.|..:.:....|.    :.||:::.|.|.::..::.|.||||
Mouse   490 ELSPVELRSTLNGVFLAVVRLAGVLSALTLATRKYF----VYLPMILYGVLPIVATISILFLPET 550

  Fly   554 LHHRLPQT------------------IEEGEEF 568
            .:  ||.|                  .:||::|
Mouse   551 FN--LPHTDIIKDMEKRKRLMSKNISKKEGQDF 581

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CarT	NP_610052.1	2A0119	44..561	CDD:273328	134/582 (23%)
CarT	NP_610052.1	MFS	182..551	CDD:119392	90/377 (24%)
Slc22a22	XP_036015188.1	MFS_OAT	108..548	CDD:340932	108/459 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	74	1.000	Domainoid score	I9078
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.010