DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CarT and Slc22a19

DIOPT Version :9

Sequence 1:	NP_610052.1	Gene:	CarT / 35334	FlyBaseID:	FBgn0032879	Length:	674	Species:	Drosophila melanogaster
Sequence 2:	NP_659034.1	Gene:	Slc22a19 / 207151	MGIID:	2442751	Length:	551	Species:	Mus musculus

Alignment Length:	552	Identity:	152/552 - (27%)
Similarity:	246/552 - (44%)	Gaps:	38/552 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 DLLPTIGEFGKYQKL-LVFG-IC------------LPACIPCGFCAFNQLFMADTPDDYWCRIPE 88
            ||:..||..|::|.| ::|. ||            ..|.||...| :..:...||..|...||
Mouse     5 DLIIQIGSLGRFQILHMIFVLICHALSAPHTLLENFTAAIPSHRC-WVPILDNDTASDNGSRI-- 66

  Fly    89 LLDLPLEQRKSLSIPKELDNDELVYSKCYTY-GVNWTQLLESGEEDDLTTMEPNASWPLIKCPQG 152
                 |.|...|.|...||:: |...||..| ...|..|..:|....:|  ||:..    .|..|
Mouse    67 -----LSQDDLLRISIPLDSN-LRPDKCRRYIQPQWHLLHLNGTFPTVT--EPDTE----PCVDG 119

  Fly   153 WEYNTSVVWSSIVIDFDLVCDQDIYPTIGLAALNTGGPVGVYLFGLLNDRGGRRLSYFVCLATLL 217
            |.|:.|...|:.|..:||||......::......||..:|..:.|.|:|:.||:|.:...|..:.
Mouse   120 WVYDQSTFLSTTVTQWDLVCGSQALNSVAKFIYMTGIFIGYIMGGHLSDKFGRKLIFTCSLLKMA 184

  Fly   218 AGSLMTSLSKDFWTWAGSRVIVGLTIPAVYQIPFIISLELVGENYRSFVTVMTCTFYTSGI--ML 280
            ......:.:..|..:...|.:.|:....:.....::.||.....:::.  ||...|..||:  .|
Mouse   185 ITETCVAFAPSFLIYCSLRFLSGIFSSTLRTNSALLILEWTSPKFQAL--VMALIFIASGVGQTL 247

  Fly   281 LSGVTYLERDWVRLSYITSLPFYAYFLYMFVMPESPRWLLMRGRLEEALKILERMAKVNG-REFP 344
            |.|:.:..|:|..|....|:|.:...:....:.||.|||:|..:.:::||.|::.|.||. :...
Mouse   248 LGGLAFAFRNWHHLQLALSVPMFLLLIPTRWLSESARWLIMANKPQKSLKELKKAACVNRIKNSG 312

  Fly   345 EAVHLKLEAQIRRDKLKKQKKKMANVGLADLCRTPNMRLKTILITLSWFANETVYLGLSYYGPAL 409
            :|:.|::...|.:::|:..:.|.:.:   ||.||||:|.:..|::...|.:....|||......|
Mouse   313 DALTLEVVKTIMKEELEAAQTKPSPL---DLFRTPNLRKRICLLSFVRFVSVMSLLGLLINIQYL 374

  Fly   410 GTNQYVSFFLSAVVELPSYLCCWYFMDTWGRRWPLSLSMILGGVACVITVMLPDDAVDETLVLYL 474
            ..|.::...|..||.:|:.:...:.|:..|||....:.|.:.|::.:..|.||.:.....:.|..
Mouse   375 SNNVFLLQCLYGVVCIPANVLGNFSMNYMGRRMTQLIFMSVLGISILAVVFLPQEMQILRVFLST 439

  Fly   475 VSKALLSASFLIIYPFAGELYPTQVRGIGIGASSYIGGLGLIGIPFITYLGKDNLKLPLVIMGFL 539
            :..|:.|||.......|.||.||.:|...:|.....|..|....|.:..|...:..||.:|.|.|
Mouse   440 LGGAISSASITSTLVHANELVPTIIRATALGVVGIAGSAGGALSPLLMILTTYSASLPWIIYGIL 504

  Fly   540 SMLGGMTGLRLPETLHHRLPQTIEEGEEFGKN 571
            ..|||:..|.||||.:..||.:|::.|...|:
Mouse   505 PFLGGLVALLLPETKNQPLPDSIQDIENKRKS 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CarT	NP_610052.1	2A0119	44..561	CDD:273328	146/534 (27%)
CarT	NP_610052.1	MFS	182..551	CDD:119392	97/371 (26%)
Slc22a19	NP_659034.1	Sugar_tr	11..525	CDD:331684	145/533 (27%)
Slc22a19	NP_659034.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	524..551		4/13 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.010