DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CarT and Slc22a3

DIOPT Version :9

Sequence 1:	NP_610052.1	Gene:	CarT / 35334	FlyBaseID:	FBgn0032879	Length:	674	Species:	Drosophila melanogaster
Sequence 2:	NP_035525.1	Gene:	Slc22a3 / 20519	MGIID:	1333817	Length:	551	Species:	Mus musculus

Alignment Length:	566	Identity:	183/566 - (32%)
Similarity:	277/566 - (48%)	Gaps:	41/566 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 PSVDEAFDLDDLLPTIGEFGKYQKLLVFGICLPACIPCGFCAFNQLFMADTPDDYWCRIPELLDL 92
            |:.|:|      |...||||::|:.:...:||.. :...|.....:|:...||.||||.|....|
Mouse     2 PTFDQA------LRKAGEFGRFQRRVFLLLCLTG-VTFAFLFVGVVFLGSQPDYYWCRGPRATAL 59

  Fly    93 -------PLEQ----RKSLSIPKELDNDELVYSKCYTYGVNWTQLLESGEEDDLTTMEPNASWPL 146
                   |.|:    ...|.:|.|....    ..|:.|.:..|........|.||.. ||.|.||
Mouse    60 AERCAWSPEEEWNLTTPELHVPAERRGQ----GHCHRYLLEATNTSSELSCDPLTAF-PNRSAPL 119

  Fly   147 IKCPQGWEYNTSVVWSSIVIDFDLVCDQDIYPTIGLAALNTGGPVGVYLFGLLNDRGGRRLSYFV 211
            :.|...|.|..:  .|:||..|||||.......:..|.||.|...|.:..|...||.||.:.|.:
Mouse   120 VSCSGDWRYVET--HSTIVSQFDLVCSNAWMLDLTQAILNLGFLAGAFTLGYAADRYGRLIIYLI 182

  Fly   212 -CLATLLAGSLMTSLSKDFWTWAGSRVIVGLTIPAVYQIPFIISLELVGENYRSFVTVMTCTFYT 275
             |....:.| ::.:.:.:|..:...|.:.|:.....:...|:|..|:||...|..|.::...|:|
Mouse   183 SCFGVGITG-VVVAFAPNFSVFVIFRFLQGVFGKGAWMTCFVIVTEIVGSKQRRIVGIVIQMFFT 246

  Fly   276 SGIMLLSGVTYLERDWVRLSYITSLPFYAYFLYMFVMPESPRWLLMRGRLEEALKILERMAKVNG 340
            .||::|.|:.|....|..:....|||.:.:.||.:|:|||||||:.|.:.|:||:||.|:||.||
Mouse   247 LGIIILPGIAYFTPSWQGIQLAISLPSFLFLLYYWVVPESPRWLITRKQGEKALQILRRVAKCNG 311

  Fly   341 REFPEAVHLKLEAQIRRDKLKKQKKKMANVGLADLCRTPNMRLKTILITLSWFANETVYLGLSYY 405
            :      ||    .....::....::::|....||.|||.||..|:::..:||.:..||.||...
Mouse   312 K------HL----SSNYSEITVTDEEVSNPSCLDLVRTPQMRKCTLILMFAWFTSAVVYQGLVMR 366

  Fly   406 GPALGTNQYVSFFLSAVVELPSYLCCWYFMDTWGRRWPLSLSMILGGVACVITVMLPDDAVDETL 470
            ...:|.|.|:.||:|.:||||..|.....::..|||.|.:.|.|:.||:|::|..||:.......
Mouse   367 LGLIGGNLYIDFFISGLVELPGALLILLTIERLGRRLPFAASNIVAGVSCLVTAFLPEGIPWLRT 431

  Fly   471 VLYLVSKALLSASFLIIYPFAGELYPTQVRGIGIGASSYIGGLGLIGIPFITY-LGKDNLKLPLV 534
            .:..:.:..::.:|.|:|....|||||.:|..|:...|.:...|.|..||:.: |....|:|||:
Mouse   432 TVATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSLCSGLCDFGGIIAPFLLFRLAAIWLELPLI 496

  Fly   535 IMGFL-SMLGGMTGLRLPETLHHRLPQTIEEGEEFGKNWQFKDCCR 579
            |.|.| |:.||:..| ||||....||:|:|:.|:.|.: |...|.|
Mouse   497 IFGILASVCGGLVML-LPETKGIALPETVEDVEKLGSS-QLHQCGR 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CarT	NP_610052.1	2A0119	44..561	CDD:273328	172/530 (32%)
CarT	NP_610052.1	MFS	182..551	CDD:119392	122/371 (33%)
Slc22a3	NP_035525.1	2A0119	12..523	CDD:273328	172/530 (32%)
Slc22a3	NP_035525.1	MFS	145..513	CDD:119392	122/379 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.920