Protein Alignment CarT and Slc22a1

DIOPT Version :10

• Sequence 1: NP_610052.1
• Gene: CarT / 35334
• FlyBaseID: FBgn0032879
• Length: 674
• Species: Drosophila melanogaster
• Sequence 2: NP_033228.2
• Gene: Slc22a1 / 20517
• MGIID: 108111
• Length: 556
• Species: Mus musculus
• Alignment Length: 564
• Identity: 181/564 - (32%)
• Similarity: 288/564 - (51%)
• Gaps: 62/564 - (10%)

  Fly    36 LDDLLPTIGEFGKYQKLLVFGICL----PACIPCGFCAFNQLFMADTPDDYWCRIPELLDLPLEQ 96
            :||:|..:||||.:||.....:||    .|.|..|.     :|:..|||.: ||.|.:.:  |.|
Mouse     4 VDDVLEHVGEFGWFQKQAFLLLCLISASLAPIYVGI-----VFLGFTPDHH-CRSPGVAE--LSQ 60

  Fly    97 RKSLSIPKELD---------NDELVYSKCYTYGVNWTQ-LLESGEEDDLTTMEPNAS-WPLIKCP 150
            |...|..:||:         .:....|:|..|.|:|.| .|:.  .|.|:::..|.| .||..|.
Mouse    61 RCGWSPAEELNYTVPGLGSAGEASFLSQCMKYEVDWNQSTLDC--VDPLSSLAANRSHLPLSPCE 123

  Fly   151 QGWEYNTSVVWSSIVIDFDLVCDQDIYPTIGLAALNTGGPVGVYLFGLLNDRGGRRLSYFV-CLA 214
            .||.|:|.  .||||.:|:|||.......:..:.:|.|..:|..:.|.:.||.||:|...| .|.
Mouse   124 HGWVYDTP--GSSIVTEFNLVCGDAWKVDLFQSCVNLGFFLGSLVVGYIADRFGRKLCLLVTTLV 186

  Fly   215 TLLAGSLMTSLSKDFWTWAGSRVIVGLTIPAVYQIPFIISLELVGENYRSFVTVMTCTFYTSGIM 279
            |.|:| ::|:::.|:.:....|::.|:.....:...:.:..|.||..||....::....:|.|::
Mouse   187 TSLSG-VLTAVAPDYTSMLLFRLLQGMVSKGSWVSGYTLITEFVGSGYRRTTAILYQVAFTVGLV 250

  Fly   280 LLSGVTYLERDWVRLSYITSLPFYAYFLYMFVMPESPRWLLMRGRLEEALKILERMAKVNGREFP 344
            .|:||.|...||..|....|||.:.:.||.:.:||||||||.:.|..:|::|:|::|:.| |:.|
Mouse   251 GLAGVAYAIPDWRWLQLAVSLPTFLFLLYYWFVPESPRWLLSQKRTTQAVRIMEQIAQKN-RKVP 314

  Fly   345 EAVHLKLEAQIRRDKLKKQKKKMANVGLADLCRTPNMRLKTILITLSWFANETVYLGLSYYGPAL 409
            .| .||:..      |::...:..:...|||.|||::|..|:::...||:...:|.||..:..|.
Mouse   315 PA-DLKMMC------LEEDASERRSPSFADLFRTPSLRKHTLILMYLWFSCAVLYQGLIMHVGAT 372

  Fly   410 GTNQYVSFFLSAVVELPSYLCCWYFMDTWGRRWPLSLSMILGGVACVITVMLPDD---------- 464
            |.|.|:.||.|::||.|:.......:|..||.:|::.|.::.|.||::.:.:|.:
Mouse   373 GANLYLDFFYSSLVEFPAAFIILVTIDRIGRIYPIAASNLVAGAACLLMIFIPHELHWLNVTLAC 437

  Fly   465 --AVDETLVLYLVSKALLSASFLIIYPFAGELYPTQVRGIGIGASSYIGGLGLIGIPFITY-LGK 526
              .:..|:||.:|  .|::|          |||||.:|.:|:...|.:..||.|..||:.: |.:
Mouse   438 LGRMGATIVLQMV--CLVNA----------ELYPTFIRNLGMMVCSALCDLGGIFTPFMVFRLME 490

  Fly   527 DNLKLPLVIMGFLSMLGGMTGLRLPETLHHRLPQTIEEGEEFGK 570
            ....|||::.|.|.:..|...|.||||....||:||||.|..|:
Mouse   491 VWQALPLILFGVLGLSAGAVTLLLPETKGVALPETIEEAENLGR 534

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CarT	NP_610052.1	MFS_SLC22	152..551	CDD:340875	128/412 (31%)
		xylE	<306..>342	CDD:182225	16/35 (46%)
Slc22a1	NP_033228.2	2A0119	12..525	CDD:273328	172/545 (32%)
		Proline-rich sequence. /evidence=ECO:0000250|UniProtKB:O15245	284..288		3/3 (100%)