DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CarT and Slc22a25

DIOPT Version :9

Sequence 1:	NP_610052.1	Gene:	CarT / 35334	FlyBaseID:	FBgn0032879	Length:	674	Species:	Drosophila melanogaster
Sequence 2:	NP_620263.1	Gene:	Slc22a25 / 192273	RGDID:	621104	Length:	552	Species:	Rattus norvegicus

Alignment Length:	558	Identity:	149/558 - (26%)
Similarity:	256/558 - (45%)	Gaps:	52/558 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 DLLPTIGEFGKYQKL-----LVFGICLPACIPCGFCAFNQLFMADTPDDYWCRIPELLD------ 91
            |||..:|..|::|.|     |:|.|.:..      .:..:.|.|..| ::.|.:| :||
  Rat     5 DLLNQVGSLGRFQILQMTFILIFNIIISP------HSLLENFTAVIP-NHRCWVP-ILDNDTVSG 61

  Fly    92 -----LPLEQRKSLSIPKELDNDELVYSKCYTY-GVNWTQLLESGEEDDLTTMEPNASWPLIKCP 150
                 |..:....:|||  ||:| |...||..: ...|..|..:|....:|  ||:..    .|.
  Rat    62 NDNGNLSQDDLLRVSIP--LDSD-LRPEKCRRFVQPQWDLLHLNGTFSSVT--EPDTE----PCV 117

  Fly   151 QGWEYNTSVVWSSIVIDFDLVCDQDIYPTIGLAALNTGGPVGVYLFGLLNDRGGRRLSYFVCLAT 215
            .||.|:.|...|:|:.::||||:.....:|......||..||..|:|.|.||.|||| ..:|.:.
  Rat   118 DGWVYDQSTFLSTIITEWDLVCESQSLDSIAKFLFLTGILVGNILYGPLTDRFGRRL-ILICASL 181

  Fly   216 LLA-GSLMTSLSKDFWTWAGSRVIVGLTIPAVYQIPFIISLELVGENYRSFVTVMTCTFYTSGIM 279
            .:| .....:.:..|..:...|.:.|::...|.....::.:|.....:::..|.:.......|..
  Rat   182 QMAVTETCAAFAPTFLIYCSLRFLAGISFSTVLTNSALLIIEWTRPKFQALATGLLLCAGAIGQT 246

  Fly   280 LLSGVTYLERDWVRLSYITSLPFYAYFLYMFVMPESPRWLLMRGRLEEALKILERMAKVNG-REF 343
            :|:|:.:..|:|..|....|:|.:...:....:.||.|||:|..:|::.||.|.::|.:|| :..
  Rat   247 VLAGLAFTVRNWHHLHLAMSVPIFFLLVPTRWLSESARWLIMTNKLQKGLKELIKVAHINGMKNS 311

  Fly   344 PEAVHLKLEAQIRRDKLKKQKKKMANVGLADLCRTPNMRLKTILITLSWFANETVYLGLSYYGPA 408
            .:.:.:::...|.:::|:..:.|.:   |.||.||||:|.:..|::|..|......:||......
  Rat   312 TDVLTIEVVRTIMKEELEASQTKSS---LWDLFRTPNLRKRICLLSLVRFVVWLSVIGLLINFQH 373

  Fly   409 LGTNQYVSFFLSAVVELPSYLCCWYFMDTWGRRWPLSLSMILGGVACVITVMLPDDAVDETLVLY 473
            |..|.::...|..::.:|:.|...:.::..|||......:.|.|::.:..:.:|    .|..:|.
  Rat   374 LRINVFLLQCLLGIITIPANLVGIFLVNHLGRRISQLFIISLFGISILAIIFVP----QEMQILR 434

  Fly   474 LVSK------ALLSASFLIIYPFAGELYPTQVRGIGIGASSYIGGLGLIGIPFITYLGKDNLKLP 532
            :|..      :.:|.|..:::  |.||.||.:|...:|.....|..|....|....|...:..||
  Rat   435 MVLATFGGVFSFVSVSSALVH--ANELLPTIIRATALGVIGIAGSTGAALSPLFMILRTYSDSLP 497

  Fly   533 LVIMGFLSMLGGMTGLRLPETLHHRLPQTIEEGEEFGK 570
            .:|.|.||.|||:..|.||||.:..||.:|::.|..|:
  Rat   498 WIIYGVLSFLGGLVVLLLPETKNQPLPDSIQDVENEGR 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CarT	NP_610052.1	2A0119	44..561	CDD:273328	143/541 (26%)
CarT	NP_610052.1	MFS	182..551	CDD:119392	95/376 (25%)
Slc22a25	NP_620263.1	2A0119	11..525	CDD:273328	142/540 (26%)
		Aldolase_II	39..>85	CDD:294146	15/50 (30%)
		MFS	125..506	CDD:119392	98/390 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.010