DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CarT and Slc22a6

DIOPT Version :9

Sequence 1:	NP_610052.1	Gene:	CarT / 35334	FlyBaseID:	FBgn0032879	Length:	674	Species:	Drosophila melanogaster
Sequence 2:	NP_032792.2	Gene:	Slc22a6 / 18399	MGIID:	892001	Length:	545	Species:	Mus musculus

Alignment Length:	564	Identity:	154/564 - (27%)
Similarity:	264/564 - (46%)	Gaps:	50/564 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 DDLLPTIGEFGKYQKLLVFGICLPACIPCGFCAFNQL--FMADTPDDYWCRIPELLDLPLEQRKS 99
            :|||..:|..|::|.:.|..:..|..:   ..:.|.|  |.|..|..: ||.|...:|..:....
Mouse     4 NDLLKQVGGVGRFQLIQVTMVVAPLLL---MASHNTLQNFTAAIPAHH-CRPPANANLSKDGGLE 64

  Fly   100 LSIPKELDNDELVYSKC--YTYGVNWTQLLESGEEDDLTTMEPNASWPLIKCPQGWEYNTSVVWS 162
            ..:|  ||......| |  :.:..|.|:...:|      ..||        |..||.|:.|...|
Mouse    65 AWLP--LDKQGRPES-CLRFPFPHNGTEANGTG------VTEP--------CLDGWVYDNSTFPS 112

  Fly   163 SIVIDFDLVCDQDIYPTIGLAALNTGGPVGVYLFGLLNDRGGRR----LSYFVCLATLLAGSLMT 223
            :||.:::|||....:..:..:....|..:|..:||.|.||.|||    |:|   |.|.::|: ..
Mouse   113 TIVTEWNLVCSHRAFRQLAQSLFMVGVLLGAMMFGYLADRLGRRKVLILNY---LQTAVSGT-CA 173

  Fly   224 SLSKDFWTWAGSRVIVGLTIPAVYQIPFIISLELVGENYRSFVTVMTCTFYTSGIMLLSGVTYLE 288
            :.:.::..:...|::.|:::.::......:::|.:..:.|::|..:....|:.|..||:|:.|..
Mouse   174 AYAPNYTVYCIFRLLSGMSLASIAINCMTLNMEWMPIHTRAYVGTLIGYVYSLGQFLLAGIAYAV 238

  Fly   289 RDWVRLSYITSLPFYAYFLYMFVMPESPRWLLMRGRLEEALKILERMAKVNGREFPEAVHLKLEA 353
            ..|..|....|:||:..|:|.:...||.||....|||:..|:.|:|:|::||::...|   ||..
Mouse   239 PHWRHLQLAVSVPFFVAFIYSWFFIESARWYSSSGRLDLTLRALQRVARINGKQEEGA---KLSI 300

  Fly   354 QIRRDKLKKQKKKMANVGLA---DLCRTPNMRLKTILITLSWFANETVYLGLSYYGPALGTNQYV 415
            ::.:..|  ||:...|.|.|   :|.|.|.:|...:.:::.|||....|.||.......|.:.|:
Mouse   301 EVLQTSL--QKELTLNKGQASAMELLRCPTLRRLFLCLSMLWFATSFAYYGLVMDLQGFGVSMYL 363

  Fly   416 SFFLSAVVELPSYLCCWYFMDTWGRRWPLSLSMILGGVACVITVMLPDDAVDETLVLYLVSKALL 480
            ...:...|:||:...|:..:::.|||.....|::|.|:..::..::|.........|.::.|..|
Mouse   364 IQVIFGAVDLPAKFVCFLVINSMGRRPAQLASLLLAGICILVNGIIPRGHTIIRTSLAVLGKGCL 428

  Fly   481 SASFLIIYPFAGELYPTQVRGIGIGASSYIGGLGLIGIPFITYLGKDNLKLPLVIMGFLSMLGGM 545
            ::||..|:.:.||||||.:|..|:|..|.:..:|.|..|.|:...:....:||.|.|.:.:....
Mouse   429 ASSFNCIFLYTGELYPTMIRQTGLGMGSTMARVGSIVSPLISMTAEFYPSIPLFIFGAVPVAASA 493

  Fly   546 TGLRLPETLHHRLPQTIEEGEEFGKNWQFKDCCRCAQKPEILSQ 589
            ....|||||...||.|:::         .|...|..||.:.|.|
Mouse   494 VTALLPETLGQPLPDTVQD---------LKSRSRGKQKQQQLEQ 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CarT	NP_610052.1	2A0119	44..561	CDD:273328	144/527 (27%)
CarT	NP_610052.1	MFS	182..551	CDD:119392	102/375 (27%)
Slc22a6	NP_032792.2	2A0119	11..509	CDD:273328	144/527 (27%)
		MFS	129..499	CDD:119392	102/378 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	515..545		5/14 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	74	1.000	Domainoid score	I9078
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.020