DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CarT and oct-2

DIOPT Version :9

Sequence 1:	NP_610052.1	Gene:	CarT / 35334	FlyBaseID:	FBgn0032879	Length:	674	Species:	Drosophila melanogaster
Sequence 2:	NP_509899.3	Gene:	oct-2 / 181325	WormBaseID:	WBGene00003843	Length:	757	Species:	Caenorhabditis elegans

Alignment Length:	615	Identity:	160/615 - (26%)
Similarity:	274/615 - (44%)	Gaps:	87/615 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 ELRQRH--KPESQPSVDEA-------FDLDDLLPTIGEFGKYQKLLVFGICLPACIPCGFCAFNQ 72
            |:|.:|  |.:...|..|.       .|.:.:|..||.. .|.:::|:.|.....:|......:.
Worm   128 EIRNQHYQKQKQYASTKETRAKRLTDIDFEGILQLIGGC-SYWQIIVYLIISVQQVPHAMFNLSV 191

  Fly    73 LFMADTPDDYWCRIP---------EL--LDLPLEQ--RKSLSIPKELD--NDELVYSKCYTYGVN 122
            ::|...| |:||:||         ||  .:...:|  ..:::.|:..:  .:||.:.:|:.:..:
Worm   192 VYMMYQP-DHWCKIPFFNEESFSAELGYTNYTWDQVLNSTIAFPRTFNKQRNELHHDQCHYFERD 255

  Fly   123 --------WTQLLESGEEDDLTTMEPNASWPLIKCPQGWEYNTSVVWSSIVIDFDLVCDQD---- 175
                    |.|:           .:.||:..:.:|.: |||:|||:..:||.:::.|||.:
Worm   256 YVHIKLSPWAQV-----------KDMNATGKINRCKE-WEYDTSVMDRTIVTEWNRVCDNNWSRA 308

  Fly   176 -IYPTIGLAALNTGGPVGVYLFGLLNDRGGRR--LSYFVCLATLLAGSLMTSLSKDFWTWAGSRV 237
             ::.:..|..|     ||.::.|.::||.||:  ::.|..| |:|.|.|:| .||:|..:...|.
Worm   309 HVHMSYSLGYL-----VGCFVGGFISDRYGRKTAITGFGIL-TMLFGFLLT-YSKEFEIFLVVRF 366

  Fly   238 IVGLTIPAVYQIPFIISLELVGENYRSFVTVMTCTFYTSGIMLLSGVTYLERDWVRLSYITSLPF 302
            ::..|..|.....:::.:|:.|..|||.|..:....:..|...|:.:.||.:.|..:..|..|..
Worm   367 LLAATNEAADLAAYVLCMEVTGTKYRSIVGSLIQAPWACGYAFLALIAYLTKSWTMIHLICVLLH 431

  Fly   303 YAYFLYMFVMPESPRWLLMRGRLEEALKILERMAKVNGREFPEAVHLKLEAQIRRDKLKKQKKKM 367
            ....:.::.:|||||||::..:.::|.||:......|....|..:.|     :|..:.||..|..
Worm   432 IISLMLLYFLPESPRWLILNNKTKQAEKIIREACHYNKSRLPSDLGL-----VRHAEKKKWMKHN 491

  Fly   368 ANVGLADLCRTPNMRLKTILITLSWFANETVYLGLSYYGPALGTNQYVS---------FFL---- 419
            .......|.|:..:|.:.:::.:.|.|.     .|.|||..:..:...|         |||
Worm   492 EKPSYFHLFRSSELRFRNVVLFIVWIAT-----ALVYYGMVIALSDQSSPGRRVFDGNFFLNNAM 551

  Fly   420 SAVVELPSYLCCWYFMDTWGRRWPLSLSMILGGVACVIT-VMLPDDAVDETLVLYLVSKALLSAS 483
            :..:|||:.:.| .|:...||:....|.:...|:..:.: ||:........|:..|:|||.:..|
Worm   552 AGAIELPTLVFC-VFLLRMGRKRSQMLVLFGSGLFLLTSVVMVYRKQSTLALIFMLLSKACIQGS 615

  Fly   484 FLIIYPFAGELYPTQVRGIGIGASSYIGGLGLIGIPFITYLGKDNLKL-PLVIMGFLSMLGGMTG 547
            |.|:|.|..||.||.||...:|.||.:..:|.....:|..|....:.| |:.|....|:|.|...
Worm   616 FNILYIFTSELNPTVVRNSAVGISSMVARMGAGASGYIAILSDVTMPLVPMTIFACFSLLAGCLV 680

  Fly   548 LRLPETLHHRLPQTIEEGEEFGKNWQFKDC 577
            |.||||....||.||.:..:..|. ..|.|
Worm   681 LLLPETQGLPLPDTILDSVQMVKR-NTKPC 709

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CarT	NP_610052.1	2A0119	44..561	CDD:273328	146/561 (26%)
CarT	NP_610052.1	MFS	182..551	CDD:119392	105/385 (27%)
oct-2	NP_509899.3	MFS_SLC22	281..673	CDD:340875	112/410 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910