DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CarT and Slc22a27

DIOPT Version :9

Sequence 1:	NP_610052.1	Gene:	CarT / 35334	FlyBaseID:	FBgn0032879	Length:	674	Species:	Drosophila melanogaster
Sequence 2:	XP_017173565.1	Gene:	Slc22a27 / 171405	MGIID:	3042283	Length:	576	Species:	Mus musculus

Alignment Length:	582	Identity:	138/582 - (23%)
Similarity:	253/582 - (43%)	Gaps:	52/582 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LSELRQRHKPESQPSVDEAFDLDDLLPTIGEFGKYQKL-LVFGICLPACIPCGFCAFNQLFMADT 78
            |..||.:.......|...:....:||..:|..|::|.| :||.:.|.|.:.......|  |.|..
Mouse     7 LGTLRVKSLSPFGNSYSASMSFQELLNQVGSLGRFQILQIVFLLLLNAIVVPHIAMEN--FTAAI 69

  Fly    79 PDDYWCRIPELLD-----------LPLEQRKSLSIPKELDNDELVYSKCYTYG-VNWTQLLESGE 131
            | ::.|.:| :||           |..:....:|||  ||:: |...||..:. ..|..|..:|.
Mouse    70 P-NHRCWVP-ILDNDTASDNGSRILSQDDLLRISIP--LDSN-LRPEKCRRFAQPQWHLLHLNGT 129

  Fly   132 EDDLTTMEPNASWPLIKCPQGWEYNTSVVWSSIVIDFDLVCDQDIYPTIGLAALNTGGPVGVYLF 196
            ..:::  ||:..    .|..||.|:.|...|:||.::||||:.....::...:...|..:|..:.
Mouse   130 FSNVS--EPDTE----PCVDGWVYDRSNFLSTIVTEWDLVCESQALNSVTKFSFMIGLFIGGIIC 188

  Fly   197 GLLNDRGGRRLSYFVCLATLLAGSL---MTSLSKDFWTWAGSRVIVGLTIPAVYQIPFIISLELV 258
            |.|:||.||:   |:....||..::   ..:.:..|:.:...|.:.||::..:.....::.||..
Mouse   189 GHLSDRLGRK---FILTCALLQFAITETCVAFAPSFFIYCSLRFLAGLSVEPILVNSHLLMLEWT 250

  Fly   259 GENYRSFVTVMTCTFYTSGIMLLSGVTYLERDWVRLSYITSLPFYAYFLYMFVMPESPRWLLMRG 323
            ...:.:.:..:.......|.|:.:|:.:|.|.|..|....|:|.:.:.:....:.||.|||::..
Mouse   251 SPKFLTMMAALLSCAPNIGYMISAGLAFLFRIWHHLQLTMSVPIFFFLILTRWLSESARWLIVTN 315

  Fly   324 RLEEALKILERMAKVNGRE-----FPEAVHLKLEAQIRRDKLKKQKKKMANVGLADLCRTPNMRL 383
            :.::.||.|.::|.:||.:     ..|.|...::|::...|.|.        .|.||..|..:|.
Mouse   316 KPQKGLKELRKVAHMNGMKNSGDLTMEIVRTSMKAELEAAKTKP--------SLRDLFHTSILRK 372

  Fly   384 K-TILITLSWFANETVYLGLSYYGPALGTN-QYVSFFLSAVVELPSYLCCWYFMDTWGRRWPLSL 446
            : .:|..:..|...::: ||:.:...|.:| ..:.|.:||:..|.|.:.. :.::..|||....:
Mouse   373 RICVLSFMRLFFTVSIF-GLAVHLQHLSSNIILLQFLISALAILVSVIGP-FVLNHIGRRITYLV 435

  Fly   447 SMILGGVACVITVMLPDDAVDETLVLYLVSKALLSASFLIIYPFAGELYPTQVRGIGIGASSYIG 511
            .|.|.|:..:|.|.:|.:.....:::..:::.:.|....:......||.||.:|...:|...:.|
Mouse   436 LMSLRGIFILIAVFVPQEMQTLRIIMATLAEGISSLCVGVSRLHTNELLPTTLRATAVGVIGFFG 500

  Fly   512 GLGLIGIPFITYLGKDNLKLPLVIMGFLSMLGGMTGLRLPETLHHRLPQTIEEGEEFGKNWQ 573
            ..|....|....|......:|.:..|..|:....|...||||.:..||   :...:.|.:|:
Mouse   501 NSGSFLSPLFMLLATYYANMPWIFYGGFSIFNAFTVFLLPETKNQPLP---DSTHDVGNDWK 559

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CarT	NP_610052.1	2A0119	44..561	CDD:273328	130/539 (24%)
CarT	NP_610052.1	MFS	182..551	CDD:119392	82/378 (22%)
Slc22a27	XP_017173565.1	MFS_OAT	134..540	CDD:340932	96/424 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	74	1.000	Domainoid score	I9078
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.010