Protein Alignment CarT and SLC22A12

DIOPT Version :9

• Sequence 1: NP_610052.1
• Gene: CarT / 35334
• FlyBaseID: FBgn0032879
• Length: 674
• Species: Drosophila melanogaster
• Sequence 2: XP_006718493.1
• Gene: SLC22A12 / 116085
• HGNCID: 17989
• Length: 578
• Species: Homo sapiens
• Alignment Length: 587
• Identity: 165/587 - (28%)
• Similarity: 255/587 - (43%)
• Gaps: 97/587 - (16%)

  Fly    38 DLLPTIGEFGKYQKLLVFGICLPACIPCGFCAFNQL--FMADTPDDYWCRIPELLD--------- 91
            :||..:|..|::|.|....:.:..   ...|..:.|  |.|..| .:.|..| |||
Human     5 ELLDLVGGLGRFQVLQTMALMVSI---MWLCTQSMLENFSAAVP-SHRCWAP-LLDNSTAQASIL 64

  Fly    92 --LPLEQRKSLSIPKELDNDELVYSKCYTYGVNWTQLLESGEEDDLTTMEPNA---SW------P 145
              |..|...::|||...:...   .:|..:.....|||           :|||   ||      |
Human    65 GSLSPEALLAISIPPGPNQRP---HQCRRFRQPQWQLL-----------DPNATATSWSEADTEP 115

  Fly   146 LIKCPQGWEYNTSVVWSSIVIDFDLVCDQDIYPTIGLAALNTGGPVGVYLFGLLNDRGGRRL--- 207
               |..||.|:.|:..|:||..::||||......:..:....|..||....|..:||.||||
Human   116 ---CVDGWVYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLT 177

  Fly   208 -SYF-----------------VC-----LATLLAGSLM-TSLSKDFWTW-------AGSRV-IVG 240
             ||.                 .|     ||..:||.:| |...:...||       ||||. .:|
Human   178 WSYLQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLRRSLTWRHAGGLHAGSRAEPLG 242

  Fly   241 LTIPAVYQIPFIISLELVGENYRSFVTVMTCTFYTSGIMLLSGVTYLERDWVRLSYITSLPFYAY 305
            |          :..:|......|..|..:....::.|..|.:.|.|..|||..|..:.|:||:..
Human   243 L----------LAVMEWTAARARPLVMTLNSLGFSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLC 297

  Fly   306 FLYMFVMPESPRWLLMRGRLEEALKILERMAKVNGREFPEAVHLKLEAQIRRDKLKKQ-KKKMAN 369
            |||.:.:.||.||||..|||:..|:.|.|:|.:||:   .||...|..::....:::: ......
Human   298 FLYSWWLAESARWLLTTGRLDWGLQELWRVAAINGK---GAVQDTLTPEVLLSAMREELSMGQPP 359

  Fly   370 VGLADLCRTPNMRLKTILITLSWFANETVYLGLSYYGPALGTNQYVSFFLSAVVELPSYLCCWYF 434
            ..|..|.|.|.:|.:|.:.||.|||....:.||:....|||:|.::......||::|:.:.....
Human   360 ASLGTLLRMPGLRFRTCISTLCWFAFGFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLL 424

  Fly   435 MDTWGRRWPLSLSMILGGVACVITVMLPDDAVDETLVLYLVSKALLSASFLIIYPFAGELYPTQV 499
            :...|||..|:.|::|.|:..:...::|.:.......|.::....:.|:|..|..::.||:||.:
Human   425 LSHLGRRPTLAASLLLAGLCILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVL 489

  Fly   500 R--GIGIGASSYIGGLGLIGIPFITYLGKDNLKLPLVIMGFLSMLGGMTGLRLPETLHHRLPQTI 562
            |  .:|:|..:..|| .::| |.:..||.....|||::.|.:.:|.|:..|.||||....||.||
Human   490 RMTAVGLGQMAARGG-AILG-PLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTI 552

  Fly   563 EE 564
            ::
Human   553 QD 554

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CarT	NP_610052.1	2A0119	44..561	CDD:273328	161/576 (28%)
		MFS	182..551	CDD:119392	114/406 (28%)
SLC22A12	XP_006718493.1	2A0119	11..551	CDD:273328	161/576 (28%)
		MFS	122..541	CDD:119392	123/433 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	5.020