Protein Alignment CarT and SLC22A7

DIOPT Version :10

• Sequence 1: NP_610052.1
• Gene: CarT / 35334
• FlyBaseID: FBgn0032879
• Length: 674
• Species: Drosophila melanogaster
• Sequence 2: XP_011512558.1
• Gene: SLC22A7 / 10864
• HGNCID: 10971
• Length: 610
• Species: Homo sapiens
• Alignment Length: 625
• Identity: 176/625 - (28%)
• Similarity: 263/625 - (42%)
• Gaps: 133/625 - (21%)

  Fly    37 DDLLPTIGEFGKYQKLLVFGICLP-ACIPCGFCAFNQLFMADTPDDYWCRIP------ELLDLPL 94
            ::||..:|.||.:|...|..:.|| ..:|..|..  .:|:|..| .:.|.:|      ...|:.|
Human     4 EELLEQVGGFGPFQLRNVALLALPRVLLPLHFLL--PIFLAAVP-AHRCALPGAPANFSHQDVWL 65

  Fly    95 EQRKSLSIPKELDNDELVYSKC----YTYGVNWTQLLES----GEEDDLTTMEPNASWPLIKCPQ 151
            |..    :|:|.|.   ..|.|    |...:..|.|.|.    ||.:|    ||    ..:.|.|
Human    66 EAH----LPREPDG---TLSSCLRFAYPQALPNTTLGEERQSRGELED----EP----ATVPCSQ 115

  Fly   152 GWEYNTSVVWSSIV--------------------------------------------------- 165
            ||||:.|...|:|.
Human   116 GWEYDHSEFSSTIATESQVGIYIIHLEVECRWRQSPWEAAGRGLPWEEAEAAGLGRDKVSYSPSW 180

  Fly   166 ----------IDFDLVCDQDIYPTIGL-AALNT----GGPVGVYLFGLLNDRGGRRLSYFVCLAT 215
                      :::||||:|.     || .|.:|    |..||...||.|:||.|||....|...:
Human   181 RESLGGLLSGMEWDLVCEQK-----GLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLLVAYVS 240

  Fly   216 LLAGSLMTSLSKDFWTWAGSRVIVGLTIPAVYQIPFIISLELVGE--------NYRSFVTVMTCT 272
            .|...|.::.|..:..:|.:|.:.|..:..     |.|.:..:||        .:|:...|::.|
Human   241 TLVLGLASAASVSYVMFAITRTLTGSALAG-----FTIIVMPLGEAELEWLDVEHRTVAGVLSST 300

  Fly   273 FYTSGIMLLSGVTYLERDWVRLSYITSLPFYAYFLYMFVMPESPRWLLMRGRLEEALKILERMAK 337
            |:|.|:|||:.|.||.|||..|....:||.....|.::.:|||.||||.:|.::||.:.|...|:
Human   301 FWTGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHVKEAHRYLLHCAR 365

  Fly   338 VNGREF------PEAVHLKLEAQIRRDKLKKQKKKMANVGLADLCRTPNMRLKTILITLSWFANE 396
            :|||..      .|||          .|:...::.:......||.|||.:|..::...:.||...
Human   366 LNGRPVCEDSFSQEAV----------SKVAAGERVVRRPSYLDLFRTPRLRHISLCCVVVWFGVN 420

  Fly   397 TVYLGLSYYGPALGTNQYVSFFLSAVVELPSYLCCWYFMDTWGRRWPLSLSMILGGVACVITVML 461
            ..|.|||.....||.|.|.:..|...|||||.|..:..:...|||...:.:::...:|....:::
Human   421 FSYYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAGTLLGTALAFGTRLLV 485

  Fly   462 PDDAVDETLVLYLVSKALLSASFLIIYPFAGELYPTQVRGIGIGASSYIGGLGLIGIPFITYLGK 526
            ..|....:.||.::.||...|:|...|.|..|||||.:|..|:|.::.:|.||....|....|..
Human   486 SSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGLTALVGRLGGSLAPLAALLDG 550

  Fly   527 DNLKLPLVIMGFLSMLGGMTGLRLPETLHHRLPQTIEEGE 566
            ..|.||.:..|.:::|...|.|.||||...:||:||::.|
Human   551 VWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQDVE 590

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CarT	NP_610052.1	MFS_SLC22	152..551	CDD:340875	132/478 (28%)
		xylE	<306..>342	CDD:182225	15/35 (43%)
SLC22A7	XP_011512558.1	MFS	106..563	CDD:475125	134/484 (28%)