DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CarT and slc22a5

DIOPT Version :9

Sequence 1:	NP_610052.1	Gene:	CarT / 35334	FlyBaseID:	FBgn0032879	Length:	674	Species:	Drosophila melanogaster
Sequence 2:	XP_002934410.2	Gene:	slc22a5 / 100486941	XenbaseID:	XB-GENE-484416	Length:	550	Species:	Xenopus tropicalis

Alignment Length:	574	Identity:	183/574 - (31%)
Similarity:	298/574 - (51%)	Gaps:	44/574 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 DLDDLLPTIGEFGKYQKLLVFGICLPACIPCGFCAFNQLFMADTPDDYWCRIPELLDLPLEQRKS 99
            |.|.....:||:|.:| :.||.:...:.||.||...:.:|:|.|| ::.|.|||..:|....|.:
Frog     3 DYDQATAFLGEWGPFQ-VSVFFLLSASIIPNGFTGLSAVFLAATP-EHRCHIPESANLSAAWRNA 65

  Fly   100 LSIPKELDNDELVYSKCYTYGV----NWTQL-LESGEEDDLTTMEPNASWPLIKCPQGWEYNTSV 159
             |||::...|    |:|..|.:    |::.| |..|.:.|:|.:|..      .|..||.|:.|:
Frog    66 -SIPRQDGQD----SQCRRYRLGTLTNYSALGLLPGRDVDVTGIEQE------PCLDGWNYSKSL 119

  Fly   160 VWSSIVIDFDLVCDQDIYPTIGLAALNTGGPVGVYLFGLLNDRGGRRLSYFVCLATLLAGSLMTS 224
            ..|:||.:::|||:.|....:..:....|..:|.::.|.::||.||:...|..:|.....|::..
Frog   120 YLSTIVTEWNLVCENDWKGPLTTSLFFVGVLIGSFVSGQMSDRFGRKKVLFATMAVQTGFSIIQV 184

  Fly   225 LSKDFWTWAGSRVIVGLTIPAVYQIPFIISLELVGENYR-SFVTVMTCTFYTSGIMLLSGVTYLE 288
            .|.::..:....:|||:...:.|...||:..|::.::.| .|.|:..|.||..|.|||....|..
Frog   185 FSVNWEMFTALFIIVGMGQISNYVAAFILGAEILDKSVRIIFSTLGVCIFYAIGYMLLPLFAYFI 249

  Fly   289 RDWVRLSYITSLPFYAYFLYMFVMPESPRWLLMRGRLEEALKILERMAKVNGREFPEAVHLKLEA 353
            |||..|....::|........:::|||||||:.:||.:||..|:.:.||.||...|:::....|.
Frog   250 RDWRTLLLALTIPGLFCIPLWWIIPESPRWLISQGRFQEAEDIIRKAAKKNGITPPDSIFNFTEL 314

  Fly   354 QIRRDKLKKQKKKMANVGLADLCRTPNMRLKTILITLSWFANETVYLGLSYYGPALGTNQYVSFF 418
            |.:::...|...      ..||.:|.|:|:.|.|..|.|......|.|||...|.|..:.||:.|
Frog   315 QEQKELTHKSHT------FLDLLKTRNIRIITFLSILLWMIISVGYFGLSLNTPNLHGDPYVNCF 373

  Fly   419 LSAVVELPSYLCCWYFMDTWGRRWPLSLSMILGGVACVITVMLPDDAVDETLVLYLVSKALLSAS 483
            |||::|:|:|:..|..:.::.||:..:.:::||||..:...::|.:....::||.::.|..::::
Frog   374 LSAIIEVPAYVIAWLLLRSFPRRYSTASTLVLGGVVLLFIQLVPQELGILSIVLVMLGKFGITSA 438

  Fly   484 FLIIYPFAGELYPTQVRGIGIGASSYIGGLGLIGIPFITYLGKDNLKLPLVIMGFLSMLGGMTGL 548
            |.::|.:..|||||.||.:|:||||....:|.|..|:..|||..:..||.::||.|::|.||..|
Frog   439 FSMVYVYTAELYPTVVRNMGVGASSMASRMGSILSPYFVYLGAYDRFLPFILMGSLTVLIGMFTL 503

  Fly   549 RLPETLHHRLPQTIEE-----------GEEFGKNWQFKDCCRCAQKPEILSQPA 591
            .|||:....||.||||           |:...|:   ||     :|..:||..|
Frog   504 CLPESHGMPLPDTIEEMLRVKGFRYKAGKRLKKD---KD-----RKASVLSNTA 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CarT	NP_610052.1	2A0119	44..561	CDD:273328	169/522 (32%)
CarT	NP_610052.1	MFS	182..551	CDD:119392	118/369 (32%)
slc22a5	XP_002934410.2	2A0119	12..516	CDD:273328	169/522 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D375160at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.110