DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CarT and slc22a13a

DIOPT Version :9

Sequence 1:	NP_610052.1	Gene:	CarT / 35334	FlyBaseID:	FBgn0032879	Length:	674	Species:	Drosophila melanogaster
Sequence 2:	XP_021322911.1	Gene:	slc22a13a / 100007819	ZFINID:	ZDB-GENE-070912-473	Length:	537	Species:	Danio rerio

Alignment Length:	574	Identity:	160/574 - (27%)
Similarity:	283/574 - (49%)	Gaps:	72/574 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 DLLPTIGEFGKYQKLLVFGICLPACI---PCGFCAFNQLFMADTPDDYWCRIPELL----DLPLE 95
            ::|..||:||.:||||:|.:|.|..|   ......||.   |||  ::.|....:|    :|..|
Zfish     6 EILEAIGDFGLFQKLLLFALCFPNLILPFQLSSLVFNH---ADT--NHHCNTDWILKADPNLTKE 65

  Fly    96 QRKSLSIPKELDNDELVYSKCYTY-GVNW--TQLLESGEEDDLTTMEPNASWPLIKCPQGWEYNT 157
            ::.:|::|:..|..   ::.|..| .|:|  :.:.|.|.....|            |..||.:|.
Zfish    66 EQLNLTLPRLSDGS---FNPCQMYKPVDWNLSAIQEYGLNQTTT------------CTDGWVHND 115

  Fly   158 SVVWSSIVIDFDLVCDQ-DIY---PTIGLAALNTGGPVGVYLFGLLNDRGGRRLSYFVCLATLLA 218
            ::..::||.||||||:. :|:   .|:..|    |..||..|||..::..||:.:..:.:..:|.
Zfish   116 TIYEATIVTDFDLVCENVNIFRGAQTVFFA----GVLVGAILFGPFSESFGRKRATQIPMVLMLI 176

  Fly   219 GSLMTSLSKDFWTWAGSRVIVGLTIPAVYQIPFIISLELVGENYRSFVTVMTCTFYTSGIMLLSG 283
            .:::|.||.:|:.:..|:.|.|:.:........|::.|.:|...||:...::......|.::...
Zfish   177 FTVVTGLSPNFYVYLVSQFINGVGLGGFRINSIILASEWIGVAQRSYAACLSQVLAALGQVMFLA 241

  Fly   284 VTYLERDWVRLSYITSLPFYAYFLYMFVMPESPRWLLMRGRLEEALKILERMAKVNGREFPEAVH 348
            |.|..|||....:|.:.|.....:|::.:|||.||||.|||.::|.|::::.|.||.|..||::
Zfish   242 VVYFVRDWRLDQFIMAGPIGIVVIYIWFLPESARWLLDRGRTKDAKKLIQKAAAVNKRAVPESL- 305

  Fly   349 LKLEAQIRRDKLKKQKKKMANVGLADLCRTPNMRLKTILITLSWFANETVYLGLSYYGPALGTNQ 413
              :|..::...::|.       |:..|..:..:|...:.||.:|.|     |.|:||..:|...:
Zfish   306 --VEEVLKEKPVEKG-------GIKILFGSRVLRKYFLAITFAWCA-----LNLAYYSLSLNVGK 356

  Fly   414 Y-VSFFLSAVV----ELPSYLCCWYFMDTWGRRWPLSLSMILGGVACVITVMLPDDAVDETLVLY 473
            : :..||:.::    |:|.:..|.:.::..||:..|.:|::|||..|::||.:|.::.....||.
Zfish   357 FGLDIFLTQLIFGLSEIPVHFLCMWSLEVVGRKPSLIVSLVLGGCLCLLTVAVPQNSSIAIAVLA 421

  Fly   474 LVSKALLSASFLIIYPFAGELYPTQVRGIGIGASSYIGGLGLIGIPFITYLGKDNLKLPLVIMGF 538
            ...:.|::|:..:...:..||:||.:|....|..|.....|.:..|.:..|...:..:|:|::..
Zfish   422 TCGRFLMNAAGSVCNVYFQELFPTSIRQTATGLGSTAARAGSMLSPVVNMLEIFHFSIPMVVISS 486

  Fly   539 LSMLGGMTGLRLPETLHHRLPQTIEEGEEFGKNWQFKDCCRCAQKPEILSQPAS 592
            |::..|:|...||||....||.:.||.|  ||           :||: |:.||:
Zfish   487 LALASGVTAFLLPETRRTELPASTEEAE--GK-----------RKPK-LTSPAT 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CarT	NP_610052.1	2A0119	44..561	CDD:273328	148/535 (28%)
CarT	NP_610052.1	MFS	182..551	CDD:119392	98/373 (26%)
slc22a13a	XP_021322911.1	Sugar_tr	12..507	CDD:331684	146/533 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	5.020