DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hr38 and NR4A3

DIOPT Version :9

Sequence 1:	NP_477119.1	Gene:	Hr38 / 35332	FlyBaseID:	FBgn0014859	Length:	1078	Species:	Drosophila melanogaster
Sequence 2:	NP_775292.1	Gene:	NR4A3 / 8013	HGNCID:	7982	Length:	637	Species:	Homo sapiens

Alignment Length:	872	Identity:	309/872 - (35%)
Similarity:	390/872 - (44%)	Gaps:	310/872 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   230 ISQVRLTNQATTSM----LLLQPNSSFSSLSPFDNFSTQTASTTTTTSASAAGHHQHHNHLLHQQ 290
            :....:|..||||:    ..::..||...|.|...:..|..........:.:.||.||:|  |..
Human    53 LGSTEITATATTSLPSISTFVEGYSSNYELKPSCVYQMQRPLIKVEEGRAPSYHHHHHHH--HHH 115

  Fly   291 HHNQQQQQQQQQQQQQQQQQQQEHLQQQHQQQLVSPQQHLLKSETLLSHEEDQLISNLTDSSVVS 355
            ||                     |.||||||..:.|          .|..||:::.:
Human   116 HH---------------------HHQQQHQQPSIPP----------ASSPEDEVLPS-------- 141

  Fly   356 HSELFSDLFF----PSDSNNSLLSPTTSGYPDNPAEDLTSSIENLTKLTCLRDKRLSSIPEQQLS 416
                 :.::|    ||       :|||..:|....              .|.|:.|.|.|.
Human   142 -----TSMYFKQSPPS-------TPTTPAFPPQAG--------------ALWDEALPSAPG---- 176

  Fly   417 SEQEQQLCLLSLRSSSDPAIALHAQQQQQQQQQQQQQQQQHQQQQQHLQLQLISPIGGPLSCGSS 481
                   |:........|..|:                                    |...|:.
Human   177 -------CIAPGPLLDPPMKAV------------------------------------PTVAGAR 198

  Fly   482 LPSFQETYSLKYNSSSGSSPQQASSSSTAAPTPTDQVLTLKMDEDCFPPLSGGWSASPPAPSQLQ 546
            .|.|.                       ..|:|                      ..|||||.
Human   199 FPLFH-----------------------FKPSP----------------------PHPPAPSP-- 216

  Fly   547 QLHTLQSQAQMSHPNSSNNSSNNAGNSHNNSGGYNYHGHFNAINASANLSPSSSASSLYEYNGVS 611
                                   ||..|.   ||:               |:::|:
Human   217 -----------------------AGGHHL---GYD---------------PTAAAA--------- 231

  Fly   612 AADNFYGQQQQQQQQSYQQHNYNSHNGERYSLPTFPTISELAAATAAVEAAAAATVSSPSVGGPP 676
                                         .|||       |.||.||  .:.||.:.|...|.|.
Human   232 -----------------------------LSLP-------LGAAAAA--GSQAAALESHPYGLPL 258

  Fly   677 PVRRASL---PVQRTVSPAGST--AQSPKLAKITLNQRHSHAHAHALQLNSAPNSAASSPASADL 736
            ..|.|.|   |:..|.||..|:  .:||.|.                   |.|:.::||....
Human   259 AKRAAPLAFPPLGLTPSPTASSLLGESPSLP-------------------SPPSRSSSSGEGT-- 302

  Fly   737 QAGRLLQAPSQLCAVCGDTAACQHYGVRTCEGCKGFFKRTVQKGSKYVCLADKNCPVDKRRRNRC 801
                        ||||||.||||||||||||||||||||||||.:||||||:|||||||||||||
Human   303 ------------CAVCGDNAACQHYGVRTCEGCKGFFKRTVQKNAKYVCLANKNCPVDKRRRNRC 355

  Fly   802 QFCRFQKCLVVGMVKEVVRTDSLKGRRGRLPSKPKSP------QESPPSPPISLITALVRSHVDT 860
            |:|||||||.|||||||||||||||||||||||||||      |.|||||||.::.||||:..|:
Human   356 QYCRFQKCLSVGMVKEVVRTDSLKGRRGRLPSKPKSPLQQEPSQPSPPSPPICMMNALVRALTDS 420

  Fly   861 TPDPSCLDYSHY----EEQSMSEADKVQQFYQLLTSSVDVIKQFAEKIPGYFDLLPEDQELLFQS 921
            ||..  ||||.|    :..:.::|:.|||||.|||:|:||.:.:||||||:.||..|||.||.:|
Human   421 TPRD--LDYSRYCPTDQAAAGTDAEHVQQFYNLLTASIDVSRSWAEKIPGFTDLPKEDQTLLIES 483

  Fly   922 ASLELFVLRLAYRARIDDTKLIFCNGTVLHRTQCLRSFGEWLNDIMEFSRSLHNLEIDISAFACL 986
            |.||||||||:.|:...:.|.:||||.||||.||||.|||||:.|.:||.:|.:|.:||.|.|||
Human   484 AFLELFVLRLSIRSNTAEDKFVFCNGLVLHRLQCLRGFGEWLDSIKDFSLNLQSLNLDIQALACL 548

  Fly   987 CALTLITERHGLREPKKVEQLQMKIIGSLRDHVTYNAEAQKKQHYFSRLLGKLPELRSLSVQGLQ 1051
            .||::|||||||:|||:||:|..||..||:||   .::.|..:...|::||.|.|||.:...|||
Human   549 SALSMITERHGLKEPKRVEELCNKITSSLKDH---QSKGQALEPTESKVLGALVELRKICTLGLQ 610

  Fly  1052 RIFYLKLEDLVPAPALIENMFVTTLPF 1078
            |||||||||||..|::|:.:|:.||||
Human   611 RIFYLKLEDLVSPPSIIDKLFLDTLPF 637

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hr38	NP_477119.1	NR_DBD_NGFI-B	747..821	CDD:143527	65/73 (89%)
Hr38	NP_477119.1	NR_LBD_DHR38_like	849..1078	CDD:132757	125/232 (54%)
NR4A3	NP_775292.1	NR_DBD_NGFI-B	301..375	CDD:143527	65/87 (75%)
NR4A3	NP_775292.1	NR_LBD	407..637	CDD:299703	126/234 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147411
Domainoid	1	1.000	146	1.000	Domainoid score	I4544
eggNOG	1	0.900	-	-		E1_KOG4217
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	473	1.000	Inparanoid score	I1512
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D216479at33208
OrthoFinder	1	1.000	-	-		FOG0001568
OrthoInspector	1	1.000	-	-		otm41653
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24085
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X978
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.900