Protein Alignment Hr38 and NR4A3

DIOPT Version :10

• Sequence 1: NP_477119.1
• Gene: Hr38 / 35332
• FlyBaseID: FBgn0014859
• Length: 1078
• Species: Drosophila melanogaster
• Sequence 2: NP_775292.1
• Gene: NR4A3 / 8013
• HGNCID: 7982
• Length: 637
• Species: Homo sapiens
• Alignment Length: 872
• Identity: 309/872 - (35%)
• Similarity: 390/872 - (44%)
• Gaps: 310/872 - (35%)

  Fly   230 ISQVRLTNQATTSM----LLLQPNSSFSSLSPFDNFSTQTASTTTTTSASAAGHHQHHNHLLHQQ 290
            :....:|..||||:    ..::..||...|.|...:..|..........:.:.||.||:|  |..
Human    53 LGSTEITATATTSLPSISTFVEGYSSNYELKPSCVYQMQRPLIKVEEGRAPSYHHHHHHH--HHH 115

  Fly   291 HHNQQQQQQQQQQQQQQQQQQQEHLQQQHQQQLVSPQQHLLKSETLLSHEEDQLISNLTDSSVVS 355
            ||                     |.||||||..:.|          .|..||:::.:
Human   116 HH---------------------HHQQQHQQPSIPP----------ASSPEDEVLPS-------- 141

  Fly   356 HSELFSDLFF----PSDSNNSLLSPTTSGYPDNPAEDLTSSIENLTKLTCLRDKRLSSIPEQQLS 416
                 :.::|    ||       :|||..:|....              .|.|:.|.|.|.
Human   142 -----TSMYFKQSPPS-------TPTTPAFPPQAG--------------ALWDEALPSAPG---- 176

  Fly   417 SEQEQQLCLLSLRSSSDPAIALHAQQQQQQQQQQQQQQQQHQQQQQHLQLQLISPIGGPLSCGSS 481
                   |:........|..|:                                    |...|:.
Human   177 -------CIAPGPLLDPPMKAV------------------------------------PTVAGAR 198

  Fly   482 LPSFQETYSLKYNSSSGSSPQQASSSSTAAPTPTDQVLTLKMDEDCFPPLSGGWSASPPAPSQLQ 546
            .|.|.                       ..|:|                      ..|||||.
Human   199 FPLFH-----------------------FKPSP----------------------PHPPAPSP-- 216

  Fly   547 QLHTLQSQAQMSHPNSSNNSSNNAGNSHNNSGGYNYHGHFNAINASANLSPSSSASSLYEYNGVS 611
                                   ||..|.   ||:               |:::|:
Human   217 -----------------------AGGHHL---GYD---------------PTAAAA--------- 231

  Fly   612 AADNFYGQQQQQQQQSYQQHNYNSHNGERYSLPTFPTISELAAATAAVEAAAAATVSSPSVGGPP 676
                                         .|||       |.||.||  .:.||.:.|...|.|.
Human   232 -----------------------------LSLP-------LGAAAAA--GSQAAALESHPYGLPL 258

  Fly   677 PVRRASL---PVQRTVSPAGST--AQSPKLAKITLNQRHSHAHAHALQLNSAPNSAASSPASADL 736
            ..|.|.|   |:..|.||..|:  .:||.|.                   |.|:.::||....
Human   259 AKRAAPLAFPPLGLTPSPTASSLLGESPSLP-------------------SPPSRSSSSGEGT-- 302

  Fly   737 QAGRLLQAPSQLCAVCGDTAACQHYGVRTCEGCKGFFKRTVQKGSKYVCLADKNCPVDKRRRNRC 801
                        ||||||.||||||||||||||||||||||||.:||||||:|||||||||||||
Human   303 ------------CAVCGDNAACQHYGVRTCEGCKGFFKRTVQKNAKYVCLANKNCPVDKRRRNRC 355

  Fly   802 QFCRFQKCLVVGMVKEVVRTDSLKGRRGRLPSKPKSP------QESPPSPPISLITALVRSHVDT 860
            |:|||||||.|||||||||||||||||||||||||||      |.|||||||.::.||||:..|:
Human   356 QYCRFQKCLSVGMVKEVVRTDSLKGRRGRLPSKPKSPLQQEPSQPSPPSPPICMMNALVRALTDS 420

  Fly   861 TPDPSCLDYSHY----EEQSMSEADKVQQFYQLLTSSVDVIKQFAEKIPGYFDLLPEDQELLFQS 921
            ||..  ||||.|    :..:.::|:.|||||.|||:|:||.:.:||||||:.||..|||.||.:|
Human   421 TPRD--LDYSRYCPTDQAAAGTDAEHVQQFYNLLTASIDVSRSWAEKIPGFTDLPKEDQTLLIES 483

  Fly   922 ASLELFVLRLAYRARIDDTKLIFCNGTVLHRTQCLRSFGEWLNDIMEFSRSLHNLEIDISAFACL 986
            |.||||||||:.|:...:.|.:||||.||||.||||.|||||:.|.:||.:|.:|.:||.|.|||
Human   484 AFLELFVLRLSIRSNTAEDKFVFCNGLVLHRLQCLRGFGEWLDSIKDFSLNLQSLNLDIQALACL 548

  Fly   987 CALTLITERHGLREPKKVEQLQMKIIGSLRDHVTYNAEAQKKQHYFSRLLGKLPELRSLSVQGLQ 1051
            .||::|||||||:|||:||:|..||..||:||   .::.|..:...|::||.|.|||.:...|||
Human   549 SALSMITERHGLKEPKRVEELCNKITSSLKDH---QSKGQALEPTESKVLGALVELRKICTLGLQ 610

  Fly  1052 RIFYLKLEDLVPAPALIENMFVTTLPF 1078
            |||||||||||..|::|:.:|:.||||
Human   611 RIFYLKLEDLVSPPSIIDKLFLDTLPF 637

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hr38	NP_477119.1	NR_DBD_NGFI-B	747..821	CDD:143527	65/73 (89%)
		NR_LBD_DHR38_like	849..1078	CDD:132757	125/232 (54%)
NR4A3	NP_775292.1	NR_DBD_NGFI-B	301..375	CDD:143527	65/87 (75%)
		NR_LBD	407..637	CDD:472173	126/234 (54%)