DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hr38 and Nr4a1

DIOPT Version :10

Sequence 1:NP_477119.1 Gene:Hr38 / 35332 FlyBaseID:FBgn0014859 Length:1078 Species:Drosophila melanogaster
Sequence 2:NP_077364.2 Gene:Nr4a1 / 79240 RGDID:620029 Length:597 Species:Rattus norvegicus


Alignment Length:656 Identity:274/656 - (41%)
Similarity:366/656 - (55%) Gaps:136/656 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   466 LQLISPIGGPLSCGSSLPSFQE-------------TYSLKYNSSSGSSPQQASSSSTAAPTPTDQ 517
            :.|.||...| :..::||||..             .|.|...:...||....||||::|.:|.. 
  Rat    35 MDLASPETAP-TAPATLPSFSTFMDGGYTGEFDTFLYQLPGTAQPCSSASSTSSSSSSATSPAS- 97

  Fly   518 VLTLKMDE----DCFP-PLSGGWSASPPAPSQLQQLHTLQSQAQMSHPNSSNNSSNNAGNSHNNS 577
             .:.|.::    .|:| .|||      |....|                              :|
  Rat    98 -ASFKFEDFQVYGCYPGTLSG------PLDETL------------------------------SS 125

  Fly   578 GGYNYHGHFNAINASANLSPSSSASSLYEYNGVSAADNFYGQQQQQQQQSYQQHNYNSHNGERYS 642
            .|.:|:|  :..:|.:..:|:...|.|..::|  :..:|      ...|:|              
  Rat   126 SGSDYYG--SPCSAPSPPTPNFQPSQLSPWDG--SFGHF------SPSQTY-------------- 166

  Fly   643 LPTFPTISELAAATAAVEAAAAATVSSPSVGGPPPVRRASLPVQRTVSPAGSTAQSPKLAKITLN 707
                             |.....|...|...||||.     |...:.||  .|..||.||:.:|.
  Rat   167 -----------------EGLRVWTEQLPKASGPPPP-----PTFFSFSP--PTGPSPSLAQSSLK 207

  Fly   708 -----QRHSHAHAHALQLNSA-PNSAASSPASADLQAGRLLQAP--------------SQLCAVC 752
                 ..|......:..:.:| |..|.:||   :.....:|.||              ...||||
  Rat   208 LFPAPATHQLGEGESYSVPAAFPGLAPTSP---NCDTSGILDAPVTSTKARSGSSGGSEGRCAVC 269

  Fly   753 GDTAACQHYGVRTCEGCKGFFKRTVQKGSKYVCLADKNCPVDKRRRNRCQFCRFQKCLVVGMVKE 817
            ||.|:||||||||||||||||||||||.:||:|||:|:||||||||||||||||||||.||||||
  Rat   270 GDNASCQHYGVRTCEGCKGFFKRTVQKSAKYICLANKDCPVDKRRRNRCQFCRFQKCLAVGMVKE 334

  Fly   818 VVRTDSLKGRRGRLPSKPKSPQESPPSPPISLITALVRSHVDTTPDPSCLDYSHYEEQSM----- 877
            |||||||||||||||||||.|   |.:.|.:|:|:|:|:|:|:.|:.:.||||.::|..:     
  Rat   335 VVRTDSLKGRRGRLPSKPKQP---PDASPTNLLTSLIRAHLDSGPNTAKLDYSKFQELVLPRFGK 396

  Fly   878 SEADKVQQFYQLLTSSVDVIKQFAEKIPGYFDLLPEDQELLFQSASLELFVLRLAYRARIDDTKL 942
            .:|..|||||.||:.|:|||:::||||||:.:|.|.||:||.:||.||||:||||||::..:.||
  Rat   397 EDAGDVQQFYDLLSGSLDVIRKWAEKIPGFIELSPGDQDLLLESAFLELFILRLAYRSKPGEGKL 461

  Fly   943 IFCNGTVLHRTQCLRSFGEWLNDIMEFSRSLHNLEIDISAFACLCALTLITERHGLREPKKVEQL 1007
            |||:|.||||.||.|.||:|:::|:.||||||:|.:|:.|||||.||.|||:||||::|::||:|
  Rat   462 IFCSGLVLHRLQCARGFGDWIDNILAFSRSLHSLGVDVPAFACLSALVLITDRHGLQDPRRVEEL 526

  Fly  1008 QMKIIGSLRDHVTYNAEAQKKQHYFSRLLGKLPELRSLSVQGLQRIFYLKLEDLVPAPALIENMF 1072
            |.:|...|::|:...|...:.....|||||||||||:|..|||||||.||||||||.|.:::.:|
  Rat   527 QNRIASCLKEHMAAVAGDPQPASCLSRLLGKLPELRTLCTQGLQRIFCLKLEDLVPPPPIVDKIF 591

  Fly  1073 VTTLPF 1078
            :.||.|
  Rat   592 MDTLSF 597

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Hr38NP_477119.1 NR_DBD_NGFI-B 747..821 CDD:143527 63/73 (86%)
NR_LBD_DHR38_like 849..1078 CDD:132757 127/233 (55%)
Nr4a1NP_077364.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..22
Required for nuclear import. /evidence=ECO:0000250|UniProtKB:P22736 170..465 159/307 (52%)
NR_DBD_NGFI-B 265..338 CDD:143527 63/72 (88%)
Required for binding NBRE-containing DNA. /evidence=ECO:0000250|UniProtKB:P12813 267..353 77/85 (91%)
Required for the interaction with RXRA. /evidence=ECO:0000250|UniProtKB:P22736 298..360 53/64 (83%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 341..360 15/21 (71%)
NR_LBD_NGFI-B 360..597 CDD:132762 128/236 (54%)
Binds lipopolysaccharide. /evidence=ECO:0000250|UniProtKB:P12813 520..543 8/22 (36%)
AF-2. /evidence=ECO:0000255|PROSITE-ProRule:PRU01189 583..594 2/10 (20%)
Blue background indicates that the domain is not in the aligned region.

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