DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hr38 and Nr4a2

DIOPT Version :9

Sequence 1:NP_477119.1 Gene:Hr38 / 35332 FlyBaseID:FBgn0014859 Length:1078 Species:Drosophila melanogaster
Sequence 2:NP_062201.2 Gene:Nr4a2 / 54278 RGDID:3202 Length:598 Species:Rattus norvegicus


Alignment Length:661 Identity:301/661 - (45%)
Similarity:384/661 - (58%) Gaps:127/661 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly   482 LPSFQETYSLKYNSSSGSSPQQASSSSTAAPTPTDQVLTLKMDEDCFPPLSGGWSASPPAPSQLQ 546
            :|..|..|        |||||.||.:|.:....:                ||.:|:....|..::
  Rat     1 MPCVQAQY--------GSSPQGASPASQSYSYHS----------------SGEYSSDFLTPEFVK 41

  Fly   547 ---QLHTLQSQAQMSHPNSSNNSSNNAGNSHNNSGGYNYHGHFNAINASANLSPSSSASSLYEYN 608
               .|...:..|..|.|:.|....       |.|.||             ::.|    ..||:. 
  Rat    42 FSMDLTNTEITATTSLPSFSTFMD-------NYSTGY-------------DVKP----PCLYQM- 81

  Fly   609 GVSAADNFYGQQQQQQQQSYQQHNYNSHNGERYSLPTFPTISELAAATAAV--EAAAAATVSSPS 671
                  ...|||...:.:..|.|||..|:    .||  |...|:...:.:|  :.::..|.|:|.
  Rat    82 ------PLSGQQSSIKVEDIQMHNYQQHS----HLP--PQSEEMMPHSGSVYYKPSSPPTPSTPG 134

  Fly   672 ----------------------VGGPPPVRRASLPVQR------TVSPAGSTAQSPKL-----AK 703
                                  |.....:.:...||.|      ..||.|:...|.::     ..
  Rat   135 FQVQHSPMWDDPGSLHNFHQNYVATTHMIEQRKTPVSRLSLFSFKQSPPGTPVSSCQMRFDGPLH 199

  Fly   704 ITLNQRHSHAHAHAL--QLNSAPNSAASSPAS---ADLQAG---RLL--QAPSQ----------L 748
            :.:|...:.:| |.:  |..:.|| ....|||   ..||.|   :||  |.||.          |
  Rat   200 VPMNPEPAGSH-HVVDGQTFAVPN-PIRKPASMGFPGLQIGHASQLLDTQVPSPPSRGSPSNEGL 262

  Fly   749 CAVCGDTAACQHYGVRTCEGCKGFFKRTVQKGSKYVCLADKNCPVDKRRRNRCQFCRFQKCLVVG 813
            ||||||.||||||||||||||||||||||||.:||||||:||||||||||||||:|||||||.||
  Rat   263 CAVCGDNAACQHYGVRTCEGCKGFFKRTVQKNAKYVCLANKNCPVDKRRRNRCQYCRFQKCLAVG 327

  Fly   814 MVKEVVRTDSLKGRRGRLPSKPKSPQE-SPPSPPISLITALVRSHVDTTPDPSCLDYSHYE---- 873
            ||||||||||||||||||||||||||: ||||||:|||:||||:|||:.|..:.||||.::    
  Rat   328 MVKEVVRTDSLKGRRGRLPSKPKSPQDPSPPSPPVSLISALVRAHVDSNPAMTSLDYSRFQANPD 392

  Fly   874 -EQSMSEADKVQQFYQLLTSSVDVIKQFAEKIPGYFDLLPEDQELLFQSASLELFVLRLAYRARI 937
             :.|..:...:||||.|||.|:::|:.:||||||:.||...||:|||:||.|||||||||||:..
  Rat   393 YQMSGDDTQHIQQFYDLLTGSMEIIRGWAEKIPGFADLPKADQDLLFESAFLELFVLRLAYRSNP 457

  Fly   938 DDTKLIFCNGTVLHRTQCLRSFGEWLNDIMEFSRSLHNLEIDISAFACLCALTLITERHGLREPK 1002
            .:.|||||||.||||.||:|.||||::.|:|||.:|.|:.||||||:|:.||.::||||||:|||
  Rat   458 VEGKLIFCNGVVLHRLQCVRGFGEWIDSIVEFSSNLQNMNIDISAFSCIAALAMVTERHGLKEPK 522

  Fly  1003 KVEQLQMKIIGSLRDHVTYNAEAQKKQHYFSRLLGKLPELRSLSVQGLQRIFYLKLEDLVPAPAL 1067
            :||:||.||:..|:||||:|.....:.:|.|:|||||||||:|..||||||||||||||||.||:
  Rat   523 RVEELQNKIVNCLKDHVTFNNGGLNRPNYLSKLLGKLPELRTLCTQGLQRIFYLKLEDLVPPPAI 587

  Fly  1068 IENMFVTTLPF 1078
            |:.:|:.||||
  Rat   588 IDKLFLDTLPF 598

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Hr38NP_477119.1 NR_DBD_NGFI-B 747..821 CDD:143527 66/83 (80%)
NR_LBD_DHR38_like 849..1078 CDD:132757 138/233 (59%)
Nr4a2NP_062201.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..22 11/28 (39%)
NR_DBD_NGFI-B 261..335 CDD:143527 66/73 (90%)
Bipartite nuclear localization signal (NLS1). /evidence=ECO:0000250 287..314 23/26 (88%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 337..361 21/23 (91%)
Nuclear localization signal (NLS1). /evidence=ECO:0000250 338..350 11/11 (100%)
NR_LBD_Nurr1 361..598 CDD:132756 140/236 (59%)
nuclear export sequence (NES1). /evidence=ECO:0000250 443..452 7/8 (88%)
nuclear export sequence (NES2). /evidence=ECO:0000250 568..577 8/8 (100%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166341060
Domainoid 1 1.000 237 1.000 Domainoid score I2249
eggNOG 1 0.900 - - E1_KOG4217
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 472 1.000 Inparanoid score I1451
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D216479at33208
OrthoFinder 1 1.000 - - FOG0001568
OrthoInspector 1 1.000 - - otm45775
orthoMCL 1 0.900 - - OOG6_105775
Panther 1 1.100 - - LDO PTHR24085
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X978
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1413.760

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