Protein Alignment Hr38 and NR4A2

DIOPT Version :9

• Sequence 1: NP_477119.1
• Gene: Hr38 / 35332
• FlyBaseID: FBgn0014859
• Length: 1078
• Species: Drosophila melanogaster
• Sequence 2: XP_005246678.1
• Gene: NR4A2 / 4929
• HGNCID: 7981
• Length: 609
• Species: Homo sapiens
• Alignment Length: 662
• Identity: 301/662 - (45%)
• Similarity: 385/662 - (58%)
• Gaps: 127/662 - (19%)

  Fly   481 SLPSFQETYSLKYNSSSGSSPQQASSSSTAAPTPTDQVLTLKMDEDCFPPLSGGWSASPPAPSQL 545
            ::|..|..|        |||||.||.:|.:....:                ||.:|:....|..:
Human    11 TMPCVQAQY--------GSSPQGASPASQSYSYHS----------------SGEYSSDFLTPEFV 51

  Fly   546 Q---QLHTLQSQAQMSHPNSSNNSSNNAGNSHNNSGGYNYHGHFNAINASANLSPSSSASSLYEY 607
            :   .|...:..|..|.|:.|....       |.|.||             ::.|    ..||:.
Human    52 KFSMDLTNTEITATTSLPSFSTFMD-------NYSTGY-------------DVKP----PCLYQM 92

  Fly   608 NGVSAADNFYGQQQQQQQQSYQQHNYNSHNGERYSLPTFPTISELAAATAAV--EAAAAATVSSP 670
                   ...|||...:.:..|.|||..|:    .||  |...|:...:.:|  :.::..|.::|
Human    93 -------PLSGQQSSIKVEDIQMHNYQQHS----HLP--PQSEEMMPHSGSVYYKPSSPPTPTTP 144

  Fly   671 S----------------------VGGPPPVRRASLPVQR------TVSPAGSTAQSPKL-----A 702
            .                      |.....:.:...||.|      ..||.|:...|.::     .
Human   145 GFQVQHSPMWDDPGSLHNFHQNYVATTHMIEQRKTPVSRLSLFSFKQSPPGTPVSSCQMRFDGPL 209

  Fly   703 KITLNQRHSHAHAHAL--QLNSAPNSAASSPAS---ADLQAG---RLL--QAPSQ---------- 747
            .:.:|...:.:| |.:  |..:.|| ....|||   ..||.|   :||  |.||.
Human   210 HVPMNPEPAGSH-HVVDGQTFAVPN-PIRKPASMGFPGLQIGHASQLLDTQVPSPPSRGSPSNEG 272

  Fly   748 LCAVCGDTAACQHYGVRTCEGCKGFFKRTVQKGSKYVCLADKNCPVDKRRRNRCQFCRFQKCLVV 812
            |||||||.||||||||||||||||||||||||.:||||||:||||||||||||||:|||||||.|
Human   273 LCAVCGDNAACQHYGVRTCEGCKGFFKRTVQKNAKYVCLANKNCPVDKRRRNRCQYCRFQKCLAV 337

  Fly   813 GMVKEVVRTDSLKGRRGRLPSKPKSPQE-SPPSPPISLITALVRSHVDTTPDPSCLDYSHYE--- 873
            |||||||||||||||||||||||||||| ||||||:|||:||||:|||:.|..:.||||.::
Human   338 GMVKEVVRTDSLKGRRGRLPSKPKSPQEPSPPSPPVSLISALVRAHVDSNPAMTSLDYSRFQANP 402

  Fly   874 --EQSMSEADKVQQFYQLLTSSVDVIKQFAEKIPGYFDLLPEDQELLFQSASLELFVLRLAYRAR 936
              :.|..:...:||||.|||.|:::|:.:||||||:.||...||:|||:||.|||||||||||:.
Human   403 DYQMSGDDTQHIQQFYDLLTGSMEIIRGWAEKIPGFADLPKADQDLLFESAFLELFVLRLAYRSN 467

  Fly   937 IDDTKLIFCNGTVLHRTQCLRSFGEWLNDIMEFSRSLHNLEIDISAFACLCALTLITERHGLREP 1001
            ..:.|||||||.||||.||:|.||||::.|:|||.:|.|:.||||||:|:.||.::||||||:||
Human   468 PVEGKLIFCNGVVLHRLQCVRGFGEWIDSIVEFSSNLQNMNIDISAFSCIAALAMVTERHGLKEP 532

  Fly  1002 KKVEQLQMKIIGSLRDHVTYNAEAQKKQHYFSRLLGKLPELRSLSVQGLQRIFYLKLEDLVPAPA 1066
            |:||:||.||:..|:||||:|.....:.:|.|:|||||||||:|..||||||||||||||||.||
Human   533 KRVEELQNKIVNCLKDHVTFNNGGLNRPNYLSKLLGKLPELRTLCTQGLQRIFYLKLEDLVPPPA 597

  Fly  1067 LIENMFVTTLPF 1078
            :|:.:|:.||||
Human   598 IIDKLFLDTLPF 609

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hr38	NP_477119.1	NR_DBD_NGFI-B	747..821	CDD:143527	66/83 (80%)
		NR_LBD_DHR38_like	849..1078	CDD:132757	138/233 (59%)
NR4A2	XP_005246678.1	NR_DBD_NGFI-B	272..346	CDD:143527	66/73 (90%)
		NR_LBD_Nurr1	372..609	CDD:132756	140/236 (59%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147409
Domainoid	1	1.000	237	1.000	Domainoid score	I2321
eggNOG	1	0.900	-	-		E1_KOG4217
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	473	1.000	Inparanoid score	I1512
Isobase	1	0.950	-	0	Normalized mean entropy	S4253
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D216479at33208
OrthoFinder	1	1.000	-	-		FOG0001568
OrthoInspector	1	1.000	-	-		otm41653
orthoMCL	1	0.900	-	-		OOG6_105775
Panther	1	1.100	-	-	LDO	PTHR24085
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3016
SonicParanoid	1	1.000	-	-		X978
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.740