DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hr38 and nr4a2b

DIOPT Version :9

Sequence 1:	NP_477119.1	Gene:	Hr38 / 35332	FlyBaseID:	FBgn0014859	Length:	1078	Species:	Drosophila melanogaster
Sequence 2:	NP_001002406.1	Gene:	nr4a2b / 436679	ZFINID:	ZDB-GENE-040718-103	Length:	586	Species:	Danio rerio

Alignment Length:	625	Identity:	276/625 - (44%)
Similarity:	364/625 - (58%)	Gaps:	119/625 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   480 SSLPSFQ---ETYSLKYNSSSGSSPQQASSSSTAAPTPTDQVLTLKMDEDCFPPLSGGWSASPPA 541
            ||||||.   :|||..|:.......|.|.|.        || |::|::|             .||
Zfish    55 SSLPSFSTFVDTYSSNYDVKPPCLYQMAHSG--------DQ-LSIKVEE-------------IPA 97

  Fly   542 PSQLQQLHTLQSQAQMSHPNSSNNSSNNAGNSHNNSGGYNYHGHFNAINASANLSPSSS------ 600
            ....||.|....||:.|.|               ::|...|.      .:|.|:|.|.|
Zfish    98 HGYHQQQHHQPHQAEESIP---------------HTGAIYYK------PSSPNISQSPSYPTAPH 141

  Fly   601 -----ASSLYEYNGVSAADNFYGQQQQQQQQSYQQHNYNSHNGERYSLPTFPTISELAAATAAVE 660
                 ..||:.::....|.:....||::...|           ..:|....|..:.:.:.....:
Zfish   142 HTWEDTGSLHSFHQNYLATSHIMDQQRKNAMS-----------RLFSFKQSPVDTPMPSCQMRFD 195

  Fly   661 AAAAATVSSPSVGGPPPVRRA----SLPVQRTVSPAGSTAQSPKLAKITLNQRHSHAHAHALQLN 721
            .:...::      ||....||    :||.            .|:       ::|....:|:|.:.
Zfish   196 GSLHVSM------GPDTAHRALDSFALPA------------PPR-------KQHGVGLSHSLNVG 235

  Fly   722 SAPNSAASSPASADLQAGRLLQAPSQ--LCAVCGDTAACQHYGVRTCEGCKGFFKRTVQKGSKYV 784
               :....||.::....|    :||.  |||||||.||||||||||||||||||||||||.:|||
Zfish   236 ---HPLLESPVASPQARG----SPSSEGLCAVCGDNAACQHYGVRTCEGCKGFFKRTVQKNAKYV 293

  Fly   785 CLADKNCPVDKRRRNRCQFCRFQKCLVVGMVKEVVRTDSLKGRRGRLPSKPKSPQESPPS-PPIS 848
            |||:||||||||||||||:||||||||||||||||||.|||||||||||||||||:.|.| .|::
Zfish   294 CLANKNCPVDKRRRNRCQYCRFQKCLVVGMVKEVVRTASLKGRRGRLPSKPKSPQDIPVSFTPVN 358

  Fly   849 LITALVRSHVDTTPDPSCLDYSHYE-----EQSMSEADKVQQFYQLLTSSVDVIKQFAEKIPGYF 908
            |:.||||:|:|:.|..:.||||.::     .....|:..:||||.|||:|:.:|:.:||||||:.
Zfish   359 LLNALVRAHIDSNPSMARLDYSKFQTSPEYHSGGDESLHIQQFYDLLTASMSIIRGWAEKIPGFT 423

  Fly   909 DLLPEDQELLFQSASLELFVLRLAYRARIDDTKLIFCNGTVLHRTQCLRSFGEWLNDIMEFSRSL 973
            :|...||||||:||.|||||||||||:.:.:.|||||||.|||:.||:|.||||::.|:|||.:|
Zfish   424 ELPKCDQELLFESAFLELFVLRLAYRSNLPEDKLIFCNGMVLHKLQCVRGFGEWIDSIVEFSSNL 488

  Fly   974 HNLEIDISAFACLCALTLITERHGLREPKKVEQLQMKIIGSLRDHVTYNAEAQKKQHYFSRLLGK 1038
            .::.:|:|||:|:.|||::||||||:||||.|:||.|:|..|:|.|:.:.|       .|:||.|
Zfish   489 QSMSLDVSAFSCIAALTIVTERHGLKEPKKAEELQNKLINCLKDQVSCSGE-------LSKLLEK 546

  Fly  1039 LPELRSLSVQGLQRIFYLKLEDLVPAPALIENMFVTTLPF 1078
            |||:|:|..||||||||||||||||.||:|:.:|..||||
Zfish   547 LPEVRALCTQGLQRIFYLKLEDLVPTPAIIDKLFHDTLPF 586

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hr38	NP_477119.1	NR_DBD_NGFI-B	747..821	CDD:143527	67/75 (89%)
Hr38	NP_477119.1	NR_LBD_DHR38_like	849..1078	CDD:132757	128/233 (55%)
nr4a2b	NP_001002406.1	NR_DBD_NGFI-B	256..330	CDD:143527	67/73 (92%)
nr4a2b	NP_001002406.1	NR_LBD_Nurr1	356..586	CDD:132756	129/236 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581236
Domainoid	1	1.000	234	1.000	Domainoid score	I2316
eggNOG	1	0.900	-	-		E1_KOG4217
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D216479at33208
OrthoFinder	1	1.000	-	-		FOG0001568
OrthoInspector	1	1.000	-	-		otm25561
orthoMCL	1	0.900	-	-		OOG6_105775
Panther	1	1.100	-	-	O	PTHR24085
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X978
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.710