Protein Alignment Hr38 and nr4a1

DIOPT Version :10

• Sequence 1: NP_477119.1
• Gene: Hr38 / 35332
• FlyBaseID: FBgn0014859
• Length: 1078
• Species: Drosophila melanogaster
• Sequence 2: XP_073794352.1
• Gene: nr4a1 / 431720
• ZFINID: ZDB-GENE-040704-11
• Length: 605
• Species: Danio rerio
• Alignment Length: 724
• Identity: 282/724 - (38%)
• Similarity: 382/724 - (52%)
• Gaps: 192/724 - (26%)

  Fly   398 KLTCLRDKR-LSSIPEQQLSSEQEQQLCLLSLRSSSDPAIALHAQQQQQQQQQQQQQQQQHQQQQ 461
            ::||::.:. :.|......|||        .|.......:|:...:|::
Zfish    31 EMTCVQSQHGVQSYESSLFSSE--------FLNPDFTSRLAMDVTEQRE---------------- 71

  Fly   462 QHLQLQLISPIGGPLSCGSSLPSFQ----------ETYSLKYNSSSGSSPQQASSSSTAAPTPTD 516
                 ||.:|         ||||..          :|||.:.         ...::||...:.:.
Zfish    72 -----QLSAP---------SLPSITSLVGGYVGEFDTYSCQI---------ATGAASTCVGSTSG 113

  Fly   517 QVLTLKMDE----DCFPPLSGGWSASPPAPSQLQQLHTLQSQAQMSHPNSSNNSSNNAGNSHN-- 575
            |:.:.|:|:    .|:|   |.::.|                 .:....||:..||..|:..:
Zfish   114 QLDSFKLDDLQVYGCYP---GTFALS-----------------YLDETLSSSGGSNCFGSPASAP 158

  Fly   576 --NSGGYNYHGHFNAINAS-----------ANLSPSSSASSLYEYNGVSAAD-NFYGQQQQQ--Q 624
              ::.||.   |.:|.:::           .:..|.:.|:|.:.:..|:|.: :..||.|.|  .
Zfish   159 SPSTPGYQ---HMSAWDSTFGPCSPDEGCWGSEKPLNQAASFFTFGHVTADELSPLGQMQSQIPD 220

  Fly   625 QQSYQQHNYNSHNGERYSLPTFPTISELAAATAAVEAAAAATVSSPSVGGPPPVRRASLPVQRTV 689
            |..:      ||                                :|..|.|.|....||   ...
Zfish   221 QDPF------SH--------------------------------TPQHGSPLPFSPLSL---EQG 244

  Fly   690 SPAGSTAQ----SPKLAKITLNQRHSHAHAHALQLNSAPNSAASSPASADLQAGRLLQAPSQLCA 750
            |..||...    |||:...|.|:                              ||        ||
Zfish   245 SRDGSGLMDGHLSPKVRSPTGNE------------------------------GR--------CA 271

  Fly   751 VCGDTAACQHYGVRTCEGCKGFFKRTVQKGSKYVCLADKNCPVDKRRRNRCQFCRFQKCLVVGMV 815
            ||||.|:||||||||||||||||||||||.:||||||:|:||||||||||||||||||||.||||
Zfish   272 VCGDNASCQHYGVRTCEGCKGFFKRTVQKNAKYVCLANKDCPVDKRRRNRCQFCRFQKCLAVGMV 336

  Fly   816 KEVVRTDSLKGRRGRLPSKPKSPQES-PPSPPISLITALVRSHVDTTPDPSCLDYSHYEEQS--- 876
            |||||||||||||||||||||:.|:| ..|.|:::|.:||.:|:|:.|..:.||||.|:|.:
Zfish   337 KEVVRTDSLKGRRGRLPSKPKAVQDSVSVSSPVNIIASLVTAHIDSNPASANLDYSKYQESTSGL 401

  Fly   877 --MSEADKVQQFYQLLTSSVDVIKQFAEKIPGYFDLLPEDQELLFQSASLELFVLRLAYRARIDD 939
              ..:|:.:||||.|||.|:|||:::|..|||:.....||||||.:||.:|||:||||||:..:.
Zfish   402 PEKEDANDIQQFYDLLTGSMDVIRKWAGSIPGFSAFCKEDQELLLESAFVELFILRLAYRSNPET 466

  Fly   940 TKLIFCNGTVLHRTQCLRSFGEWLNDIMEFSRSLHNLEIDISAFACLCALTLITERHGLREPKKV 1004
            .|||||||.|||||||:||||:|::.|||||:|||.|.:|||||:||..|.:||:||||:|||::
Zfish   467 DKLIFCNGVVLHRTQCVRSFGDWIDSIMEFSQSLHRLNLDISAFSCLATLVIITDRHGLKEPKRI 531

  Fly  1005 EQLQMKIIGSLRDHVTYNAEAQKKQHYFSRLLGKLPELRSLSVQGLQRIFYLKLEDLVPAPALIE 1069
            |..|.::|..|||||:.:|....:.:..||||.||||||:|..||||||||||||||||.|.:::
Zfish   532 EDFQNRLITCLRDHVSTSALEVGRPNSLSRLLSKLPELRTLCTQGLQRIFYLKLEDLVPPPPIVD 596

  Fly  1070 NMFVTTLPF 1078
            .:|:.||||
Zfish   597 KIFMDTLPF 605

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hr38	NP_477119.1	NR_DBD_NGFI-B	747..821	CDD:143527	64/73 (88%)
		NR_LBD_DHR38_like	849..1078	CDD:132757	130/233 (56%)
nr4a1	XP_073794352.1	None