DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hr38 and Nr4a3

DIOPT Version :9

Sequence 1:	NP_477119.1	Gene:	Hr38 / 35332	FlyBaseID:	FBgn0014859	Length:	1078	Species:	Drosophila melanogaster
Sequence 2:	NP_056558.1	Gene:	Nr4a3 / 18124	MGIID:	1352457	Length:	627	Species:	Mus musculus

Alignment Length:	755	Identity:	304/755 - (40%)
Similarity:	382/755 - (50%)	Gaps:	189/755 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   375 SPTTSGYPDNP-AEDLTSSIEN--LTKLTC------LRDKRLSSIP------EQQLSSEQEQQLC 424
            ||..|.|.... ..:.|:.|.|  .||||.      :.....:|:|      |...||.:.:..|
Mouse    11 SPPGSTYATQTYGSEYTTEIMNPDYTKLTMDLGSTGIMATATTSLPSFSTFMEGYPSSCELKPSC 75

  Fly   425 LLSLRSSSD-PAIALHAQQQQQQQQQQQQQQQQHQQQQQHLQLQLISPIGGPLSCGSSLPSFQET 488
            |..:..|.. |.|.:...::.............|..|||.   ..|.|..||..  ..|||
Mouse    76 LYQMPPSGPRPLIKMEEGREHGYHHHHHHHHHHHHHQQQQ---PSIPPPSGPED--EVLPS---- 131

  Fly   489 YSLKYNSSSGSSPQQASSSSTAAPTPTDQVLTLKMDEDCFPPLSGG-WSAS-PPAPS-------- 543
            .|:.:..|..|:|          .||.            |||.:|. |... |.||.
Mouse   132 TSMYFKQSPPSTP----------TTPG------------FPPQAGALWDDELPSAPGCIAPGPLL 174

  Fly   544 --QLQQLHTLQSQAQM--------SHPNSSNNSSNNAGNSHNNSGGYNYHGHFNAINASANLSPS 598
              |::.:..:.:.|:.        .||    .:.:.||..|.   ||:               |:
Mouse   175 DPQMKAVPPMAAAARFPIFFKPSPPHP----PAPSPAGGHHL---GYD---------------PT 217

  Fly   599 SSASSLYEYNGVSAADNFYGQQQQQQQQSYQQHNYNSHNGERYSLPTFPTISELAAATAAVEAAA 663
            ::|:                                      .|||       |.||.||  .:.
Mouse   218 AAAA--------------------------------------LSLP-------LGAAAAA--GSQ 235

  Fly   664 AATVSSPSVGGPPPVRRASL---PVQRTVSPAGST--AQSPKLAKITLNQRHSHAHAHALQLNSA 723
            ||.:.....|.|...|.|:|   |:..|.||..|:  .:||.|.                   |.
Mouse   236 AAALEGHPYGLPLAKRTATLTFPPLGLTASPTASSLLGESPSLP-------------------SP 281

  Fly   724 PNSAASSPASADLQAGRLLQAPSQLCAVCGDTAACQHYGVRTCEGCKGFFKRTVQKGSKYVCLAD 788
            ||.::||....              ||||||.||||||||||||||||||||||||.:||||||:
Mouse   282 PNRSSSSGEGT--------------CAVCGDNAACQHYGVRTCEGCKGFFKRTVQKNAKYVCLAN 332

  Fly   789 KNCPVDKRRRNRCQFCRFQKCLVVGMVKEVVRTDSLKGRRGRLPSKPKSP------QESPPSPPI 847
            ||||||||||||||:|||||||.|||||||||||||||||||||||||||      |.|||||||
Mouse   333 KNCPVDKRRRNRCQYCRFQKCLSVGMVKEVVRTDSLKGRRGRLPSKPKSPLQQEPSQPSPPSPPI 397

  Fly   848 SLITALVRSHVDTTPDPSCLDYSHY----EEQSMSEADKVQQFYQLLTSSVDVIKQFAEKIPGYF 908
            .::.||||:..|.||..  ||||.|    :..:.::|:.|||||.|||:|:||.:.:||||||:.
Mouse   398 CMMNALVRALTDATPRD--LDYSRYCPTDQATAGTDAEHVQQFYNLLTASIDVSRSWAEKIPGFT 460

  Fly   909 DLLPEDQELLFQSASLELFVLRLAYRARIDDTKLIFCNGTVLHRTQCLRSFGEWLNDIMEFSRSL 973
            ||..|||.||.:||.||||||||:.|:...:.|.:||||.||||.||||.|||||:.|.:||.:|
Mouse   461 DLPKEDQTLLIESAFLELFVLRLSIRSNTAEDKFVFCNGLVLHRLQCLRGFGEWLDSIKDFSLNL 525

  Fly   974 HNLEIDISAFACLCALTLITERHGLREPKKVEQLQMKIIGSLRDHVTYNAEAQKKQHYFSRLLGK 1038
            .:|.:||.|.|||.||::|||||||:|||:||:|..||..||:||   ..:.|..:....::|..
Mouse   526 QSLNLDIQALACLSALSMITERHGLKEPKRVEELCTKITSSLKDH---QRKGQALEPSEPKVLRA 587

  Fly  1039 LPELRSLSVQGLQRIFYLKLEDLVPAPALIENMFVTTLPF 1078
            |.|||.:..||||||||||||||||.|::|:.:|:.||||
Mouse   588 LVELRKICTQGLQRIFYLKLEDLVPPPSVIDKLFLDTLPF 627

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hr38	NP_477119.1	NR_DBD_NGFI-B	747..821	CDD:143527	65/73 (89%)
Hr38	NP_477119.1	NR_LBD_DHR38_like	849..1078	CDD:132757	125/232 (54%)
Nr4a3	NP_056558.1	Interaction with NCOA1, NCOA2, NCOA3 and KAT2B. /evidence=ECO:0000269\|PubMed:12709428	1..292		85/399 (21%)
		Required for DNA-PK heterotrimer. /evidence=ECO:0000250\|UniProtKB:Q92570	1..139		33/136 (24%)
		Activation function (AF)-1 domain. /evidence=ECO:0000269\|PubMed:12709428	1..112		22/100 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	96..162		22/96 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	268..289		8/39 (21%)
		NR_DBD_NGFI-B	291..365	CDD:143527	65/87 (75%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	365..395		22/29 (76%)
		Interaction with KAT2B. /evidence=ECO:0000269\|PubMed:12709428	380..627		136/251 (54%)
		NR_LBD	397..627	CDD:416257	126/234 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837338
Domainoid	1	1.000	146	1.000	Domainoid score	I4519
eggNOG	1	0.900	-	-		E1_KOG4217
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	473	1.000	Inparanoid score	I1485
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D216479at33208
OrthoFinder	1	1.000	-	-		FOG0001568
OrthoInspector	1	1.000	-	-		otm43698
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24085
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X978
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.860