Protein Alignment Hr38 and nhr-6

DIOPT Version :9

• Sequence 1: NP_477119.1
• Gene: Hr38 / 35332
• FlyBaseID: FBgn0014859
• Length: 1078
• Species: Drosophila melanogaster
• Sequence 2: NP_497731.1
• Gene: nhr-6 / 175462
• WormBaseID: WBGene00003605
• Length: 619
• Species: Caenorhabditis elegans
• Alignment Length: 645
• Identity: 179/645 - (27%)
• Similarity: 267/645 - (41%)
• Gaps: 175/645 - (27%)

  Fly   477 SCGSSLPSFQETYSLKYNSSSGSSPQQASSSSTAAP---------TPTDQVLTLKMDEDCFPPLS 532
            ||.|         |..|.....||..:..|.:|.|.         ..:|||.|:
 Worm    63 SCSS---------SFDYGEFGPSSSSRKGSKTTDADLDSLFHSLVETSDQVNTV----------- 107

  Fly   533 GGWSASPPAPSQLQQLHTLQSQAQMSHPNSSNN---SSNNAGNSHNNSGGYNYHGHFNAINASAN 594
                   |.|:: .::.::..:.:.. |:||::   |..||..:|..|                .
 Worm   108 -------PKPTK-TEVESIPEEFEQK-PSSSSHRLPSEMNASITHIKS----------------E 147

  Fly   595 LSPSSSA-----SSLY------EYNGVSAADNFYGQQQQQQQQS--YQQHNYNSHNGERYSLPTF 646
            |.|:..|     :.|:      .||..:.:::|..........|  |.||              |
 Worm   148 LDPTMQAFQMPHNDLFLATAAPHYNPFALSNDFMPNPLMPSFTSPFYPQH--------------F 198

  Fly   647 PTISELAAATAAVEAAAAATVSSPSVGGPPPVRRASLPVQRTVSPAGSTAQSPKLAKITLNQRHS 711
            | :|:      :...:...|.||.:.||.|....:|||.        |..|.....:..||
 Worm   199 P-VSD------SRRGSQGTTSSSNNTGGTPSPHSSSLPT--------SPPQLQGFLRSFLN---- 244

  Fly   712 HAHAHALQLNSAPNSAASSPASADLQAGRLLQAPSQLCAVCGDTAACQHYGVRTCEGCKGFFKRT 776
                        |:: .|:|.|..:.:...|.| .::||||.|.|.|.|||.|||||||||||||
 Worm   245 ------------PDN-LSTPTSFGVPSETALDA-DKMCAVCNDRAVCLHYGARTCEGCKGFFKRT 295

  Fly   777 VQKGSKYVCLADKNCPVDKRRRNRCQFCRFQKCLVVGMVKEVVRTDSLKGRRGRLPSKPK----S 837
            |||.|||.|..:|.||:|||.|:|||:||:||||.||||||:||..||.||||||.||.|    .
 Worm   296 VQKNSKYTCAGNKTCPIDKRYRSRCQYCRYQKCLEVGMVKEIVRHGSLSGRRGRLSSKTKLARSE 360

  Fly   838 PQESPPSPPISLITALVRSHVDTTPDPSCLDYSHYEEQSMSEADKVQQFYQ---------LLTSS 893
            .|.|||.|.::|:...:..|.:.|                    .|:||.|         :|...
 Worm   361 DQPSPPLPLLALMGKAIEDHTNMT--------------------VVRQFMQPFDETIALRILHGE 405

  Fly   894 VDVIKQFAEKIPGYFDLLPEDQELLFQSASLELFVLRLAYRARIDDTKLIFCNGTVLHRTQCLRS 958
            :...|:....:|...::.|.|.::|...:...:..:|:|.|.......::|.:|.:.    .|.:
 Worm   406 LHATKKLLMAMPQISEIQPADFQILLSRSFFAIMAIRVANRCGNSTDTIMFESGELF----SLNA 466

  Fly   959 FGEWLNDIMEF----SRSLHNL-EIDISAFACLCALTLI---TERH--GLREPKKVEQLQMKIIG 1013
            |......|:.|    :|:..:| :.:..|||...||..:   ||.:  ||.....|:|:|..||.
 Worm   467 FPACFQQIIRFMVDKARTFSSLVDWEPQAFAAFIALQFLAGNTEHNVLGLTNKPLVDQVQSTIIN 531

  Fly  1014 SLRDHVTYNAEAQKKQHYFSRLLGKLPELRSLSVQGLQRIF--------YLKLEDLVPAP 1065
            :|:||.   :.:|.|.....||..:.....:|.:|.|..::        ::.|.:|..||
 Worm   532 ALKDHC---SGSQNKLAKIVRLTQEFDVFHALGLQALDILYPSHQLPEEFMFLINLTRAP 588

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hr38	NP_477119.1	NR_DBD_NGFI-B	747..821	CDD:143527	53/73 (73%)
		NR_LBD_DHR38_like	849..1078	CDD:132757	52/244 (21%)
nhr-6	NP_497731.1	Pax2_C	165..261	CDD:289189	27/141 (19%)
		NR_DBD_NGFI-B	266..340	CDD:143527	53/73 (73%)
		HOLI	405..560	CDD:214658	37/161 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159517
Domainoid	1	1.000	124	1.000	Domainoid score	I3439
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4253
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D216479at33208
OrthoFinder	1	1.000	-	-		FOG0001568
OrthoInspector	1	1.000	-	-		oto19967
orthoMCL	1	0.900	-	-		OOG6_105775
Panther	1	1.100	-	-	LDO	PTHR24085
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X978
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.800