DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hr38 and Nr4a1

DIOPT Version :9

Sequence 1:NP_477119.1 Gene:Hr38 / 35332 FlyBaseID:FBgn0014859 Length:1078 Species:Drosophila melanogaster
Sequence 2:NP_034574.1 Gene:Nr4a1 / 15370 MGIID:1352454 Length:601 Species:Mus musculus


Alignment Length:659 Identity:276/659 - (41%)
Similarity:372/659 - (56%) Gaps:138/659 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   466 LQLISPIGGPLSCGSSLPS---FQETYSLKYN-------------SSSGSSPQQASSSSTAAPTP 514
            :.|.||...| :..::|||   |.:.|:.:::             ||:.||....||||::|.:|
Mouse    35 MDLASPETAP-AAPATLPSFSTFMDGYTGEFDTFLYQLPGTTQPCSSACSSASSTSSSSSSATSP 98

  Fly   515 TDQVLTLKMDE----DCFP-PLSGGWSASPPAPSQLQQLHTLQSQAQMSHPNSSNNSSNNAGNSH 574
            ..  .:.|.::    .|:| .|||      |....|                             
Mouse    99 AS--ASFKFEDFQVYGCYPGTLSG------PLDETL----------------------------- 126

  Fly   575 NNSGGYNYHGHFNAINASANLSPSSSASSLYEYNGVSAADNFYGQQQQQQQQSYQQHNYNSHNGE 639
             :|.|..|:|       |...:||.|..: ::.:.:|..|..:|.....|               
Mouse   127 -SSSGSEYYG-------SPCSAPSPSTPN-FQPSQLSPWDGSFGHFSPSQ--------------- 167

  Fly   640 RYSLPTFPTISELAAATAAVEAAAAATVSSPSVGGPPPVRRASLPVQRTVSPAGSTAQSPKLAKI 704
                    |...|.|.|..:..|::         ||||.     |...:.||  .|..||.||:.
Mouse   168 --------TYEGLWAWTEQLPKASS---------GPPPP-----PTFFSFSP--PTGPSPSLAQS 208

  Fly   705 TLN-----QRHSHAHAHALQLNSA-PNSAASSPASADLQAGRLLQAP--------------SQLC 749
            :|.     ..|......:..:.:| |..|.:||   :.....:|.||              ...|
Mouse   209 SLKLFPPPATHQLGEGESYSMPAAFPGLAPTSP---NRDTSGILDAPVTSTKSRSGASGGSEGRC 270

  Fly   750 AVCGDTAACQHYGVRTCEGCKGFFKRTVQKGSKYVCLADKNCPVDKRRRNRCQFCRFQKCLVVGM 814
            |||||.|:||||||||||||||||||||||.:||:|||:|:||||||||||||||||||||.|||
Mouse   271 AVCGDNASCQHYGVRTCEGCKGFFKRTVQKSAKYICLANKDCPVDKRRRNRCQFCRFQKCLAVGM 335

  Fly   815 VKEVVRTDSLKGRRGRLPSKPKSPQESPPSPPISLITALVRSHVDTTPDPSCLDYSHYEEQSM-- 877
            ||||||||||||||||||||||.|   |.:.|.:|:|:|:|:|:|:.|..:.||||.::|..:  
Mouse   336 VKEVVRTDSLKGRRGRLPSKPKQP---PDASPTNLLTSLIRAHLDSGPSTAKLDYSKFQELVLPR 397

  Fly   878 ---SEADKVQQFYQLLTSSVDVIKQFAEKIPGYFDLLPEDQELLFQSASLELFVLRLAYRARIDD 939
               .:|..|||||.||:.|:|||:::||||||:.:|.|.||:||.:||.||||:||||||::..:
Mouse   398 FGKEDAGDVQQFYDLLSGSLDVIRKWAEKIPGFIELCPGDQDLLLESAFLELFILRLAYRSKPGE 462

  Fly   940 TKLIFCNGTVLHRTQCLRSFGEWLNDIMEFSRSLHNLEIDISAFACLCALTLITERHGLREPKKV 1004
            .|||||:|.|||:.||.|.||:|:::|:.||||||:|.:|:.|||||.||.|||:||||::|::|
Mouse   463 GKLIFCSGLVLHQLQCARGFGDWIDNILAFSRSLHSLGVDVPAFACLSALVLITDRHGLQDPRRV 527

  Fly  1005 EQLQMKIIGSLRDHVTYNAEAQKKQHYFSRLLGKLPELRSLSVQGLQRIFYLKLEDLVPAPALIE 1069
            |:||.:|...|::|:...|...:.....|||||||||||:|..|||||||.||||||||.|.:::
Mouse   528 EELQNRIASCLKEHMATVAGDPQPASCLSRLLGKLPELRTLCTQGLQRIFCLKLEDLVPPPPIVD 592

  Fly  1070 NMFVTTLPF 1078
            .:|:.||.|
Mouse   593 KIFMDTLSF 601

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Hr38NP_477119.1 NR_DBD_NGFI-B 747..821 CDD:143527 63/73 (86%)
NR_LBD_DHR38_like 849..1078 CDD:132757 126/233 (54%)
Nr4a1NP_034574.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..21
Required for nuclear import. /evidence=ECO:0000250|UniProtKB:P22736 173..469 160/317 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 180..205 11/40 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 237..268 6/33 (18%)
NR_DBD_NGFI-B 268..342 CDD:143527 63/73 (86%)
Required for the interaction with RXRA. /evidence=ECO:0000250|UniProtKB:P22736 302..364 53/64 (83%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 345..364 15/21 (71%)
NR_LBD_NGFI-B 364..601 CDD:132762 127/236 (54%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167837340
Domainoid 1 1.000 237 1.000 Domainoid score I2311
eggNOG 1 0.900 - - E1_KOG4217
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D216479at33208
OrthoFinder 1 1.000 - - FOG0001568
OrthoInspector 1 1.000 - - otm43698
orthoMCL 1 0.900 - - OOG6_105775
Panther 1 1.100 - - O PTHR24085
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3016
SonicParanoid 1 1.000 - - X978
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1312.740

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