DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hr38 and nr4a2

DIOPT Version :10

Sequence 1:NP_477119.1 Gene:Hr38 / 35332 FlyBaseID:FBgn0014859 Length:1078 Species:Drosophila melanogaster
Sequence 2:NP_001093678.1 Gene:nr4a2 / 100101682 XenbaseID:XB-GENE-480893 Length:591 Species:Xenopus tropicalis


Alignment Length:662 Identity:301/662 - (45%)
Similarity:378/662 - (57%) Gaps:136/662 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   482 LPSFQETYSLKYNSSSGSSPQQASSSSTAAPTPTDQVLTLKMDEDCFPPLSGGWSASPPAPSQLQ 546
            :|..|..|        |||||.||        |..|..|...        ||.:|:....|..::
 Frog     1 MPCVQAQY--------GSSPQGAS--------PASQSYTYHS--------SGEYSSDFLTPEFVK 41

  Fly   547 ---QLHTLQSQAQMSHPNSSNNSSNNAGNSHNNSGGYNYHGHFNAINASANLSPSSSASSLYEYN 608
               .|...:..|..|.|:.|....|                    .|.|.::.|    ..||:. 
 Frog    42 FSMDLTNTEITATTSLPSFSTFMDN--------------------YNTSYDVKP----PCLYQM- 81

  Fly   609 GVSAADNFYGQQQQQQQQSYQQHNYNSHNGERYSLPTFPTISELAAATAAVEAAAAATVSSPSVG 673
                  ...|||...:.:..|.|.|..|.    .||  |...|:.:.:.:|       ...||  
 Frog    82 ------PLSGQQSSVKVEDIQMHGYQQHG----HLP--PQSEEMMSHSGSV-------YYKPS-- 125

  Fly   674 GPPPVRRASLPVQRT---------------------------------VSPAGSTAQSPKLA--- 702
            .||.......|||.:                                 .||.|:...|.::.   
 Frog   126 SPPTSSTPGFPVQHSPMWDNHGSLHSFNQNYVATRGGHVPRLSLFSFKQSPPGTPVSSCQMRFDG 190

  Fly   703 -KITLNQRHSHAHAHAL--QLNSAPN--SAASSPASADLQAGRLLQ-------------APSQ-- 747
             .:::|...|.|| |.:  |..:.||  ...:|.....||.|...|             :||.  
 Frog   191 HHVSMNPETSGAH-HVIDGQTFAVPNPIRKQASMGFPGLQLGHASQLIDSQVPSPPSRGSPSNEG 254

  Fly   748 LCAVCGDTAACQHYGVRTCEGCKGFFKRTVQKGSKYVCLADKNCPVDKRRRNRCQFCRFQKCLVV 812
            |||||||.||||||||||||||||||||||||.:||||||:||||||||||||||:|||||||||
 Frog   255 LCAVCGDNAACQHYGVRTCEGCKGFFKRTVQKNAKYVCLANKNCPVDKRRRNRCQYCRFQKCLVV 319

  Fly   813 GMVKEVVRTDSLKGRRGRLPSKPKSPQE-SPPSPPISLITALVRSHVDTTPDPSCLDYSHYE--- 873
            |||||||||||||||||||||||||||| ||||||:|||:||||:|||:.|..|.||||.::   
 Frog   320 GMVKEVVRTDSLKGRRGRLPSKPKSPQEPSPPSPPVSLISALVRAHVDSNPAVSSLDYSRFQANP 384

  Fly   874 EQSMS--EADKVQQFYQLLTSSVDVIKQFAEKIPGYFDLLPEDQELLFQSASLELFVLRLAYRAR 936
            |..|:  :...:||||.|||.|:::|:.:||||||:.:|..:||:|||:||.|||||||||||:.
 Frog   385 EYQMNGDDTQHIQQFYDLLTGSMEIIRGWAEKIPGFSELHKQDQDLLFESAFLELFVLRLAYRSN 449

  Fly   937 IDDTKLIFCNGTVLHRTQCLRSFGEWLNDIMEFSRSLHNLEIDISAFACLCALTLITERHGLREP 1001
            ..:.|||||||.||:|.||:|.||||::.|::||.:||::.||||||:|:.||.:|||||||:||
 Frog   450 PAEGKLIFCNGVVLNRLQCVRGFGEWIDSIVDFSSNLHSMNIDISAFSCIAALAVITERHGLKEP 514

  Fly  1002 KKVEQLQMKIIGSLRDHVTYNAEAQKKQHYFSRLLGKLPELRSLSVQGLQRIFYLKLEDLVPAPA 1066
            |:||:||.||:..|:||||:|.....:.:|.|:|||||||||:|..||||||||||||||||.||
 Frog   515 KRVEELQNKIVNCLKDHVTFNNGGLNRPNYLSKLLGKLPELRTLCTQGLQRIFYLKLEDLVPPPA 579

  Fly  1067 LIENMFVTTLPF 1078
            :|:.:|:.||||
 Frog   580 IIDKLFLDTLPF 591

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Hr38NP_477119.1 NR_DBD_NGFI-B 747..821 CDD:143527 67/75 (89%)
NR_LBD_DHR38_like 849..1078 CDD:132757 138/233 (59%)
nr4a2NP_001093678.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..22 12/36 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 110..133 6/31 (19%)
NR_DBD_NGFI-B 254..328 CDD:143527 67/73 (92%)
Bipartite nuclear localization signal (NLS1). /evidence=ECO:0000250 280..307 23/26 (88%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 330..354 22/23 (96%)
Nuclear localization signal (NLS1). /evidence=ECO:0000250 331..343 11/11 (100%)
NR_LBD 360..591 CDD:472173 136/230 (59%)
nuclear export sequence (NES1). /evidence=ECO:0000250 436..445 7/8 (88%)
nuclear export sequence (NES2). /evidence=ECO:0000250 561..570 8/8 (100%)

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