Protein Alignment Hr38 and nr4a2a

DIOPT Version :9

• Sequence 1: NP_477119.1
• Gene: Hr38 / 35332
• FlyBaseID: FBgn0014859
• Length: 1078
• Species: Drosophila melanogaster
• Sequence 2: NP_001106956.1
• Gene: nr4a2a / 100008101
• ZFINID: ZDB-GENE-990415-184
• Length: 598
• Species: Danio rerio
• Alignment Length: 674
• Identity: 296/674 - (43%)
• Similarity: 372/674 - (55%)
• Gaps: 153/674 - (22%)

  Fly   482 LPSFQETYSLKYNSSSGSSPQQASSSSTAAPTPTDQVLTLKMDEDCFPPLSGGWSASPPAPS--- 543
            :|..|..|        |||||.||.:|.:....|                ||.:|.....|.
Zfish     1 MPCVQAQY--------GSSPQGASPASQSYSYHT----------------SGEYSCDFLTPEFVK 41

  Fly   544 -QLQQLHTLQSQAQMSHPNSSNNSSNNAGNSHNNSGGYNYHGHFNAINASANLSPSSSASSLYEY 607
             .:...:|..:.|..|.|:.|....|                    .|.|.::.|    ..||:.
Zfish    42 FSMDLTNTEITAATTSLPSFSTFMDN--------------------YNTSYDVKP----PCLYQV 82

  Fly   608 NGVSAADNFYGQQQQQQQQSYQQHNYN--SHNGERYSLPTFPTISELAAATAAVEAAAAATVSSP 670
                   ...|:|...:.:..|.|.|:  ||.|        |...|:.|....|....    |||
Zfish    83 -------PHSGEQSSIKVEDVQMHTYHQQSHLG--------PQSEEMMAHPGPVYFKP----SSP 128

  Fly   671 SVGGPP----------------------------------PVRRASLPVQRTVSPAGSTAQSPKL 701
            ...||.                                  ||.|.|| .....||.|:...|.::
Zfish   129 HGPGPANFQVQPNHMWEDPGSLHTFHQNYMTSHMIDQRKNPVSRLSL-FSFKQSPPGTPVSSCQM 192

  Fly   702 --------------------------AKITLNQRHSHAHAHALQL---NSAPNSAASSPASADLQ 737
                                      ...|:.::...|..|:|||   :...:|...||.|..
Zfish   193 RFDGPLHVSMHDSTGAHRTLDSQSFAVPSTIRKQAGIAFTHSLQLSHGHQLMDSQVPSPPSRG-- 255

  Fly   738 AGRLLQAPSQ--LCAVCGDTAACQHYGVRTCEGCKGFFKRTVQKGSKYVCLADKNCPVDKRRRNR 800
                  :||.  |||||||.||||||||||||||||||||||||.:||||||:||||||||||||
Zfish   256 ------SPSTEGLCAVCGDNAACQHYGVRTCEGCKGFFKRTVQKNAKYVCLANKNCPVDKRRRNR 314

  Fly   801 CQFCRFQKCLVVGMVKEVVRTDSLKGRRGRLPSKPKSPQE-SPPSPPISLITALVRSHVDTTPDP 864
            ||:|||||||||||||||||||:||||||||||||||||| ||||||:|||:||||:|||:.|..
Zfish   315 CQYCRFQKCLVVGMVKEVVRTDNLKGRRGRLPSKPKSPQESSPPSPPVSLISALVRAHVDSNPSM 379

  Fly   865 SCLDYSHYE-----EQSMSEADKVQQFYQLLTSSVDVIKQFAEKIPGYFDLLPEDQELLFQSASL 924
            :.|||:.::     :.|..:...:||||.|||.|:::|:.:||||||:.||...||:|||:||.|
Zfish   380 NSLDYTRFQANPDYQLSGDDTQHIQQFYDLLTGSMEIIRGWAEKIPGFTDLPKPDQDLLFESAFL 444

  Fly   925 ELFVLRLAYRARIDDTKLIFCNGTVLHRTQCLRSFGEWLNDIMEFSRSLHNLEIDISAFACLCAL 989
            ||||||||||:...::|||||||.||||.||:|.||||::.|:|||.:|.|:.:|||||:|:.||
Zfish   445 ELFVLRLAYRSNPMESKLIFCNGVVLHRLQCVRGFGEWIDSIVEFSSNLQNMNLDISAFSCIAAL 509

  Fly   990 TLITERHGLREPKKVEQLQMKIIGSLRDHVTYNAEAQKKQHYFSRLLGKLPELRSLSVQGLQRIF 1054
            .::||||||:|||:||.||.||:..|:|.||:|.....:.:|.|:|||||||||:|..|||||||
Zfish   510 AMVTERHGLKEPKRVEDLQNKIVNCLKDQVTFNGGGLNRPNYLSKLLGKLPELRTLCTQGLQRIF 574

  Fly  1055 YLKLEDLVPAPALIENMFVTTLPF 1078
            |||||||||.||:|:.:|:.||||
Zfish   575 YLKLEDLVPPPAIIDKLFLDTLPF 598

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hr38	NP_477119.1	NR_DBD_NGFI-B	747..821	CDD:143527	67/75 (89%)
		NR_LBD_DHR38_like	849..1078	CDD:132757	135/233 (58%)
nr4a2a	NP_001106956.1	NR_DBD_NGFI-B	261..335	CDD:143527	67/73 (92%)
		NR_LBD_Nurr1	367..598	CDD:132756	133/230 (58%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581237
Domainoid	1	1.000	234	1.000	Domainoid score	I2316
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D216479at33208
OrthoFinder	1	1.000	-	-		FOG0001568
OrthoInspector	1	1.000	-	-		otm25561
orthoMCL	1	0.900	-	-		OOG6_105775
Panther	1	1.100	-	-	LDO	PTHR24085
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3016
SonicParanoid	1	1.000	-	-		X978
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.880