DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hr38 and ar

DIOPT Version :9

Sequence 1:	NP_477119.1	Gene:	Hr38 / 35332	FlyBaseID:	FBgn0014859	Length:	1078	Species:	Drosophila melanogaster
Sequence 2:	NP_001076592.1	Gene:	ar / 100005148	ZFINID:	ZDB-GENE-060131-1	Length:	868	Species:	Danio rerio

Alignment Length:	786	Identity:	165/786 - (20%)
Similarity:	288/786 - (36%)	Gaps:	142/786 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   350 DSSVVSHSELFSDLFFPSDSNNSLLSPTTSGYPDNPAEDLTSSIENLTKLTCLRDKRLSSI---- 410
            |:||.|.|...:.....|.|::|  |.|||......|.:|..:: :::....:....|..:
Zfish   153 DASVASSSRACTTATITSSSSSS--STTTSCTISETARELCKAV-SVSLGLAMESSELGEVGQHH 214

  Fly   411 --PEQQLSSEQEQQLCLLSLRSSSDPAIALHAQQQQQQQQQQQQQQQQHQQQQQHLQ-------- 465
              |...|::|..:::.|..:     |.:.....:::..::.::......:.:.:.|:
Zfish   215 APPPPPLTTESSEEIYLYGM-----PLLDCSVSEREAGRKDREYALAAGRDRGEELRGRDKVLGM 274

  Fly   466 -----LQLISPIGGPLSCGSSLPSFQETYSLKYNSSSGSSPQQASSSSTAAPTPTDQVLTLKMDE 525
                 |:.::.....|.|.::..:.......::.|.||.. ...||..|||.|..|      ||
Zfish   275 LKSGDLEQLAGEVTTLQCSNASRANLTADVHEFGSLSGDI-ANLSSEGTAAQTAPD------MD- 331

  Fly   526 DCFPPLSGGWSASPPAPS-QLQQLHTLQSQAQMSHPNSSNNSSNNAGNSHNNSGGY-----NYHG 584
                        .|.|.| |.:|| ...|....:||...|..|::...|.:.||.:     :|..
Zfish   332 ------------GPRAASCQFEQL-LPASMTHYAHPELENGPSHSFVKSTSMSGEFAGPMEDYTN 383

  Fly   585 HFNAINASANLSPSSSASSLYEYNGVSAADNFYGQQQQQQQQSYQQHNYNSHNGERYSLPTFPTI 649
            .:| :.....:.|.       :.|...|..:.|.:..            |.|.|.......:.|.
Zfish   384 LYN-VRIKTEMMPR-------DLNDTWAYPHRYAEDS------------NGHYGPPKQRTPYATG 428

  Fly   650 SELAAATAAVEAAAAATVSSPSVGGPPPVRRASLPVQRTVSPAGSTAQSPKLAKITLNQRHSHAH 714
            .|                 .|.:..|....|::..|.|...|.........|.      ||.:.:
Zfish   429 HE-----------------PPFICNPYEYGRSTALVPRERPPHEQWYPGGMLT------RHPYPN 470

  Fly   715 AHALQLNSAPNSAASSPASADLQAGR-------LLQAPSQLCAVCGDTAACQHYGVRTCEGCKGF 772
            ...::.........:|........||       ....|.:.|.:|.|.|:..|||..||..||.|
Zfish   471 VPGVKNEMGEWMDVTSFTDGRFDGGRSDIFPMEFFLPPQRTCLICSDEASGCHYGALTCGSCKVF 535

  Fly   773 FKRTVQKGSKYVCLADKNCPVDKRRRNRCQFCRFQKCLVVGM---VKEVVRTDSLKG--RRGRLP 832
            |||..:...||:|.:..:|.:||.||..|..||.:||..|||   .:::.:...:||  ..|.:.
Zfish   536 FKRAAEGKQKYLCASRNDCTIDKLRRKNCPSCRLKKCFEVGMTLGARKLRKIGQMKGPDEVGAVQ 600

  Fly   833 SKPKSPQESPPSPPISLITALVRSHVDTTPDPSCLDYSHYEEQSMSEADKVQQFYQLLTS----- 892
            ...::.|...|.|.::..:.|:..::....:|..::..|...|..|.|       .||||
Zfish   601 GPSETVQCLSPKPNLTFHSQLIFLNILEAIEPEVVNAGHDHGQPDSAA-------ALLTSLNELG 658

  Fly   893 ---SVDVIKQFAEKIPGYFDLLPEDQELLFQSASLELFVLRLAYRA--RIDDTKLIFCNGTVLH- 951
               .|.|:| :|:.:||:.:|..:||..:.|...:.:.|..|.:|:  ..:...|.|....|.:
Zfish   659 ERQLVKVVK-WAKGLPGFRNLHVDDQMTVIQHTWMGVMVFALGWRSYKNANARMLYFAPDLVFND 722

  Fly   952 RTQCLRSFGEWLNDIMEFSRSLHNLEIDISAFACLCALTL--ITERHGLREPKKVEQLQMKIIGS 1014
            |...:.|..|....:...|:....|::....|.|:.||.|  :....||:..|..::|::..|..
Zfish   723 RRMHVSSMYEHCVQMKHLSQEFVLLQVTQEEFLCMKALLLFSVIPVEGLKSQKYFDELRLTYINE 787

  Fly  1015 LRDHVTYNAEAQKKQHY--FSRLLGKLPELRSLSVQGLQRIFY------LKLEDLVPAPALIENM 1071
            |...:.|..:......:  .:||:..|..:    ||.|.:..:      ..|...|..|.:|..:
Zfish   788 LDRLINYGRKTNCAMRFQQLTRLMDSLQPV----VQKLHQFTFDLFVQARSLPTKVSFPEMIAEI 848

  Fly  1072 FVTTLP 1077
            ....:|
Zfish   849 ISVQVP 854

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hr38	NP_477119.1	NR_DBD_NGFI-B	747..821	CDD:143527	31/76 (41%)
Hr38	NP_477119.1	NR_LBD_DHR38_like	849..1078	CDD:132757	54/250 (22%)
ar	NP_001076592.1	NR_DBD_AR	507..588	CDD:143547	32/80 (40%)
ar	NP_001076592.1	NR_LBD	622..867	CDD:299703	53/245 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	146	1.000	Inparanoid score	I4398
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.960