DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cen and Cdr2l

DIOPT Version :9

Sequence 1:	NP_610049.1	Gene:	Cen / 35330	FlyBaseID:	FBgn0032876	Length:	790	Species:	Drosophila melanogaster
Sequence 2:	XP_340934.5	Gene:	Cdr2l / 360656	RGDID:	1306881	Length:	466	Species:	Rattus norvegicus

Alignment Length:	526	Identity:	137/526 - (26%)
Similarity:	223/526 - (42%)	Gaps:	109/526 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 SAGCENVS----------QFMLDDLQLAAELGKTLLERNKELETFIKEYKIKGDEQELEILHLRK 62
            :||.|..|          |.:..||.|||||||||||||||||..:::.....:||..||.:|.|
  Rat     4 AAGMEEYSAEEEESWYDHQDLEQDLHLAAELGKTLLERNKELEESLQQMYSTNEEQVQEIEYLTK 68

  Fly    63 HINAMTEVNDSRLKVYEQLEVGIQDLERANQRLNLEKNRDKKQIKTLTTNTEVLEARCEELSQLL 127
            .::.:..||:...||||||::..:|||..||||.||....:::|..||...|.|:::.|||.
  Rat    69 QLDTLRLVNEQHAKVYEQLDLTARDLELTNQRLVLESKAAQQKIHGLTETIERLQSQVEELQ--- 130

  Fly   128 SDARQSLSTERRKVDQYQQERYRMQHSTEGSVSSHSIQSLCKEQSVEFSKLDVMAIANSTGLED- 191
            :...|....|:.:|.:.::||.|..|:..      .::.||               .:....||
  Rat   131 AQVEQLRGLEQVRVRREKRERRRTIHTFP------CLKELC---------------TSPRRCEDA 174

  Fly   192 --ISFSNATMCERTAVKGEDNEELVKLLSEMEVLKRDFLAEQQRCTELEEQLVTIIQDNQGLQTR 254
              :..|:..:..|..  .::||.|..|:.   ||:.....|:||....|.:...::|:...|:.:
  Rat   175 FRLHSSSLELGPRPL--EQENERLQTLVG---VLRSQVSQERQRKERAEREYTLVLQEYTELERQ 234

  Fly   255 LLENSANEG-TMSMHE-EFSLLDDVRQGQMCSRCLRDINESNTNMDDQSSIAPTEEIYEDDDRSI 317
            |.|   .|| .:.:.| |..||:           |:.:.::.|.:     :|..|.:.|    ::
  Rat   235 LCE---MEGCRLRVQELEAELLE-----------LQQMKQAKTYL-----LARDEHLAE----AL 276

  Fly   318 LSESTSKCDNSGADYKERFRIPE--DLNPNSSDKPNPYRDLVEKYEA----LVEVKRTSNAVKSN 376
            |:..|              :.||  |..|.|.|.||. :|.|....|    .|....:..|:.:.
  Rat   277 LAPLT--------------QAPEADDPQPGSGDDPNA-QDGVSSPAASPSHAVRKSCSDTALNAI 326

  Fly   377 FTSNPDGK-----TMTESSQGKKSETIVNSSKES--------DLMLDSTRKRTPTEFSESETTSS 428
            ...:|..:     |:..:|..::..:|:....|.        :.:|...|:...........||.
  Rat   327 VAKDPASRHAGNLTLHANSVRRRGMSILREVDEQYHALLEKYEELLSKCRQHGAGVRHAGVQTSR 391

  Fly   429 GFSDETSNKSTQTDERPSYFLCSISNGNDCKFSIYDDVSPIESHF-RNRPEYRELFKEIFGVLKK 492
            ..|.::|.:.....|.      |...|...:.|:...|..::... :::|||:.||||||..::|
  Rat   392 PISRDSSWRDLLGGEE------SQGEGKAGEKSLSQHVEAVDKRLEQSQPEYKALFKEIFARIQK 450

  Fly   493 A-ADNN 497
            . ||.|
  Rat   451 TKADIN 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cen	NP_610049.1	SMC_prok_B	<13..>255	CDD:274008	77/254 (30%)
Cdr2l	XP_340934.5	Smc	<20..>234	CDD:224117	76/242 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353482
Domainoid	1	1.000	100	1.000	Domainoid score	I6845
eggNOG	1	0.900	-	-		E1_2C4BD
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	100	1.000	Inparanoid score	I4898
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1101523at2759
OrthoFinder	1	1.000	-	-		FOG0003445
OrthoInspector	1	1.000	-	-		otm44436
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19232
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.860