DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cen and cdr2l

DIOPT Version :9

Sequence 1:	NP_610049.1	Gene:	Cen / 35330	FlyBaseID:	FBgn0032876	Length:	790	Species:	Drosophila melanogaster
Sequence 2:	NP_001303823.1	Gene:	cdr2l / 336227	ZFINID:	ZDB-GENE-030131-8171	Length:	464	Species:	Danio rerio

Alignment Length:	513	Identity:	131/513 - (25%)
Similarity:	208/513 - (40%)	Gaps:	113/513 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 DLQLAAELGKTLLERNKELETFIKEYKIKGDEQELEILHLRKHINAMTEVNDSRLKVYEQLEVGI 85
            ||.|||||||||||||||||..:::..|..:||..||.:|.|.:..:.|:|:...||||||:|..
Zfish    27 DLHLAAELGKTLLERNKELEDSLQQMYINNEEQVQEIEYLTKQMEMLREMNEQHAKVYEQLDVTA 91

  Fly    86 QDLERANQRLNLEKNRDKKQIKTLTTNTEVLEARCEELSQLLSDARQSLSTERRKVDQYQQERYR 150
            ::||..|::|.||....:::|..||...|:|:.:.:.|:..:.:.|   :.|..:|.:.::||.:
Zfish    92 RELEITNEKLVLESKGSQQKIDRLTGTMEMLQGQVDTLTARVEELR---TLEELRVRREKKERRK 153

  Fly   151 MQHSTEGSVSSHSIQSLCKEQSVEFSKLDVMAIANSTGLEDISFSNATMCERTAVKGEDNEELVK 215
            ..||..      .::.||.....|.|     .:.:..|..|:        |......|:||.|..
Zfish   154 TVHSFP------CLKELCTAPRYEDS-----FMVSDPGSGDL--------EECQPADEENEHLRV 199

  Fly   216 LLSEMEVLKRDFLAEQQRCTELEEQLVTIIQDNQGLQTRLLENSANEGTMSMHE---EFSLLDDV 277
            ::|.   |:....||:.|....|.:...::|:.:.|:.|||  .|......:||   |...:..:
Zfish   200 MVSS---LRAAVAAERGRREAAERECAAVLQEFERLEQRLL--GAESCQRRVHELEAELQEMQQL 259

  Fly   278 RQGQMC---------SRCLRDINESNT--------NMDDQSSIAPTEEIYEDDDRSILSESTSKC 325
            |:.::|         ...|....|::|        |.|.....||..:...|    ...::.|..
Zfish   260 RKSRVCLLSGEEGLEQTLLNCAPETDTPDEAVMAQNGDANDGAAPVRKSCSD----TALDAISAV 320

  Fly   326 DNSGADYKERFRIPEDLNPNSSDK---------PNPYRDLVEKYEALV-EVKRTSNAVK--SNFT 378
            |.||     |.:....|:.|...|         ...|..|:||||.|: :.:|...:::  ...|
Zfish   321 DASG-----RRKGSYALHANGVRKRGMSILREVDEQYHALLEKYEELLGKCRRHEESLRHAEVQT 380

  Fly   379 SNPDGKTMTESSQGKKSETIVNSSKESDLMLDSTRKRTPTEFSESETTSSGFSDETSNKSTQTDE 443
            |.|..:.              .|.||..:........||.:...:.....|.|.:..    ..|:
Zfish   381 SRPVSRD--------------PSMKECRVAEPQQPPPTPPQTPSTPEALEGISRQVE----AVDK 427

  Fly   444 RPSYFLCSISNGNDCKFSIYDDVSPIESHFRNRPEYRELFKEIFGVLKKAADNNEEDK 501
            |.|                           :|.|||:.||||||..|::...:....|
Zfish   428 RLS---------------------------QNTPEYKALFKEIFSRLQRTKSDINSTK 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cen	NP_610049.1	SMC_prok_B	<13..>255	CDD:274008	73/233 (31%)
cdr2l	NP_001303823.1	SMC_N	<13..>279	CDD:330553	82/278 (29%)
cdr2l	NP_001303823.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	371..419		9/61 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595607
Domainoid	1	1.000	122	1.000	Domainoid score	I5592
eggNOG	1	0.900	-	-		E1_2C4BD
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	122	1.000	Inparanoid score	I4721
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1101523at2759
OrthoFinder	1	1.000	-	-		FOG0003445
OrthoInspector	1	1.000	-	-		otm25719
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19232
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5462
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.890