DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cen and Cdr2

DIOPT Version :9

Sequence 1:	NP_610049.1	Gene:	Cen / 35330	FlyBaseID:	FBgn0032876	Length:	790	Species:	Drosophila melanogaster
Sequence 2:	NP_001020853.1	Gene:	Cdr2 / 308958	RGDID:	1310578	Length:	453	Species:	Rattus norvegicus

Alignment Length:	529	Identity:	125/529 - (23%)
Similarity:	210/529 - (39%)	Gaps:	149/529 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 DLQLAAELGKTLLERNKELETFIKEYKIKGDEQELEILHLRKHINAMTEVNDSRLKVYEQLEVGI 85
            |||||||||||||:||.|||..:::......||..||.:|.|.:..:.::|:...||||||:|..
  Rat    26 DLQLAAELGKTLLDRNTELEDSLQQMYTTNQEQLQEIEYLTKQVELLRQMNEQHAKVYEQLDVTA 90

  Fly    86 QDLERANQRLNLEKNRDKKQIKTLT-------TNTEVLEARCEELSQLLSDARQSLSTERRKVDQ 143
            ::||..||:|..|....:::|.:||       ||.:.|:::.|||.......||....:.|....
  Rat    91 RELEETNQKLVAESKASQQKILSLTETIECLQTNIDHLQSQVEELKSNQGRGRQKACDQERPAPS 155

  Fly   144 YQ--QERYRM-QHSTEGSVSSHSIQSLCKEQSVEFSKLDVMAIANSTGLEDISFSNATMCERTAV 205
            :.  :|.|.: ||.....|.:..|.||..:||.:
  Rat   156 FSCLKELYDLRQHFVYDHVFAEKITSLQSQQSPD------------------------------- 189

  Fly   206 KGEDNEELVKLLSEMEVLKRDFLAEQQRCTELEEQLVTIIQDNQGLQTRLLENSANEGTMSMHEE 270
             .|:||.|.|.::   :|:.....|:::...:|.:...::::|..|:.:|   ||.:...:..:|
  Rat   190 -EEENEHLKKAVT---MLQAQLSLERKKRVSVEAEYKVVLKENSELEQQL---SATDAYRARAQE 247

  Fly   271 FSLLDDVRQGQMCSRCLRDINESNTNMDDQSSIAPTEEIYEDDDRSILSESTSKCDNSGADYKER 335
            .                            ::.:|...::.:.:...:          :|.
  Rat   248 L----------------------------EAEVAEMRQMLQAEHPFV----------NGV----- 269

  Fly   336 FRIPEDLNPNSSDKP--NPYRDLVEKYEALVEVKRTSNAVKSNFTSNPDG--KTMTESSQGKKSE 396
                |.|.|:|...|  .|.:.|:|:.                |.:.|:.  |.:..||    ||
  Rat   270 ----EKLVPDSLFVPFKEPSQSLLEEM----------------FLAAPEAHRKPLKRSS----SE 310

  Fly   397 TIVNSSKESDLMLD----------STRKRTPTEFSESETTSSGF--------------SDETSNK 437
            |:::|....|::.|          :.::|..:...|.:|..|..              .|..|:|
  Rat   311 TVLSSLAGDDIVKDHEDTCIRRAKAVKQRGISLLHEVDTQYSALKVKYEELLRKCQQEQDSLSHK 375

  Fly   438 STQTDERPSYFLCSISNGNDCKFSIYDDV----SPIESHFRNRPEYRELFKEIFGVLKKAADNNE 498
            :.||....:..|..:...::...|.::..    .||.|.....|||:.||||||..:||.....:
  Rat   376 AVQTSRLLTRDLTGLVPQSEAGASGWEPTPVSPEPISSPTTTPPEYKALFKEIFSCIKKTKQEID 440

  Fly   499 ED--KLPSL 505
            |.  |.|||
  Rat   441 EQRTKYPSL 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cen	NP_610049.1	SMC_prok_B	<13..>255	CDD:274008	70/243 (29%)
Cdr2	NP_001020853.1	Smc	<22..>261	CDD:224117	75/300 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353483
Domainoid	1	1.000	100	1.000	Domainoid score	I6845
eggNOG	1	0.900	-	-		E1_2C4BD
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	100	1.000	Inparanoid score	I4898
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1101523at2759
OrthoFinder	1	1.000	-	-		FOG0003445
OrthoInspector	1	1.000	-	-		otm44436
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR19232
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.860