DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cen and CDR2L

DIOPT Version :9

Sequence 1:	NP_610049.1	Gene:	Cen / 35330	FlyBaseID:	FBgn0032876	Length:	790	Species:	Drosophila melanogaster
Sequence 2:	NP_055418.2	Gene:	CDR2L / 30850	HGNCID:	29999	Length:	465	Species:	Homo sapiens

Alignment Length:	525	Identity:	131/525 - (24%)
Similarity:	220/525 - (41%)	Gaps:	108/525 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 SAGCENVS----------QFMLDDLQLAAELGKTLLERNKELETFIKEYKIKGDEQELEILHLRK 62
            :||.|:.|          |.:..||.|||||||||||||||||..:::.....:||..||.:|.|
Human     4 AAGMEDFSAEEEESWYDQQDLEQDLHLAAELGKTLLERNKELEGSLQQMYSTNEEQVQEIEYLTK 68

  Fly    63 HINAMTEVNDSRLKVYEQLEVGIQDLERANQRLNLEKNRDKKQIKTLTTNTEVLEARCEELSQLL 127
            .::.:..||:...||||||::..:|||..|.||.||....:::|..||...|.|:|:.|||.
Human    69 QLDTLRHVNEQHAKVYEQLDLTARDLELTNHRLVLESKAAQQKIHGLTETIERLQAQVEELQ--- 130

  Fly   128 SDARQSLSTERRKVDQYQQERYRMQHSTEGSVSSHSIQSLCKEQSVEFSKLDVMAIANST---GL 189
            :...|....|:.:|.:.::||.|..|:..      .::.||.....:    |...:.:|:   |.
Human   131 AQVEQLRGLEQLRVLREKRERRRTIHTFP------CLKELCTSPRCK----DAFRLHSSSLELGP 185

  Fly   190 EDISFSNATMCERTAVKGEDNEELVKLLSEMEVLKRDFLAEQQRCTELEEQLVTIIQDNQGLQTR 254
            ..:.              ::||.|..|:.   .|:.....|:||....|.:...::|:...|:.:
Human   186 RPLE--------------QENERLQTLVG---ALRSQVSQERQRKERAEREYTAVLQEYSELERQ 233

  Fly   255 LLENSANEGTMSMHE-EFSLLDDVRQGQMCSRCLRDINESNTNM---DD---QSSIAPTEEIYED 312
            |.|..|..  :.:.| |..||:           |:.:.::.|.:   ||   ::.:||..:..|.
Human   234 LCEMEACR--LRVQELEAELLE-----------LQQMKQAKTYLLGPDDHLAEALLAPLTQAPEA 285

  Fly   313 DDRSILSESTSKCDNSGADYKERFRIPEDLNPNSSDKPNPYRDLVEKYEALVEVKRTSNAVKSNF 377
            ||     ....:.|:.||.           :..||...:|..        :|....:..|:.:..
Human   286 DD-----PQPGRGDDLGAQ-----------DGVSSPAASPGH--------VVRKSCSDTALNAIV 326

  Fly   378 TSNPDGK-----TMTESSQGKKSETIVNSSKES--------DLMLDSTRKRTPTEFSESETTSSG 429
            ..:|..:     |:..:|..|:..:|:....|.        :.:|...|:...........||..
Human   327 AKDPASRHAGNLTLHANSVRKRGMSILREVDEQYHALLEKYEELLSKCRQHGAGVRHAGVQTSRP 391

  Fly   430 FSDETSNKSTQTDERPSYFLCSISNGNDCKFSIYDDVSPIESHF-RNRPEYRELFKEIFGVLKKA 493
            .|.::|.:..:..|...   ..:..|..   |:...|..::... :::|||:.||||||..::|.
Human   392 ISRDSSWRDLRGGEEGQ---GEVKAGEK---SLSQHVEAVDKRLEQSQPEYKALFKEIFSRIQKT 450

  Fly   494 -ADNN 497
             ||.|
Human   451 KADIN 455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cen	NP_610049.1	SMC_prok_B	<13..>255	CDD:274008	75/254 (30%)
CDR2L	NP_055418.2	Smc	<2..>241	CDD:224117	81/266 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	282..314		9/55 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	382..417		6/40 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159438
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_2C4BD
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1101523at2759
OrthoFinder	1	1.000	-	-		FOG0003445
OrthoInspector	1	1.000	-	-		otm40307
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19232
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5462
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.840