DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cen and Cdr2l

DIOPT Version :9

Sequence 1:	NP_610049.1	Gene:	Cen / 35330	FlyBaseID:	FBgn0032876	Length:	790	Species:	Drosophila melanogaster
Sequence 2:	NP_001074398.1	Gene:	Cdr2l / 237988	MGIID:	2684867	Length:	465	Species:	Mus musculus

Alignment Length:	526	Identity:	134/526 - (25%)
Similarity:	223/526 - (42%)	Gaps:	110/526 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 SAGCENVS----------QFMLDDLQLAAELGKTLLERNKELETFIKEYKIKGDEQELEILHLRK 62
            :||.|:.|          |.:..||.|||||||||||||||||..:::.....:||..||.:|.|
Mouse     4 AAGMEDYSAEEEESWYDHQDLEQDLHLAAELGKTLLERNKELEESLQQMYSTNEEQVHEIEYLTK 68

  Fly    63 HINAMTEVNDSRLKVYEQLEVGIQDLERANQRLNLEKNRDKKQIKTLTTNTEVLEARCEELSQLL 127
            .::.:..||:...||||||::..:|||..||||.:|....:::|..||...|.|:::.|||.
Mouse    69 QLDTLRLVNEQHAKVYEQLDLTARDLELTNQRLVMESKAAQQKIHGLTETIERLQSQVEELQ--- 130

  Fly   128 SDARQSLSTERRKVDQYQQERYRMQHSTEGSVSSHSIQSLCKEQSVEFSKLDVMAIANST---GL 189
            :...|....|:.::.:.::||.|..|:..      .::.||.....|    |...:.:|:   |.
Mouse   131 AQVEQLRGLEQLRIRREKRERRRTIHTFP------CLKELCTSSRCE----DAFRLHSSSLELGP 185

  Fly   190 EDISFSNATMCERTAVKGEDNEELVKLLSEMEVLKRDFLAEQQRCTELEEQLVTIIQDNQGLQTR 254
            ..:.              ::||.|..|:.   ||:.....|:||....|.:...::|:...|:.:
Mouse   186 RPLE--------------QENERLQTLVG---VLRSQVSQERQRKERAEREYTVVLQEYTELERQ 233

  Fly   255 LLENSANEG-TMSMHE-EFSLLDDVRQGQMCSRCLRDINESNTNMDDQSSIAPTEEIYEDDDRSI 317
            |.|   .|| .:.:.| |..||:           |:.:.::.|.:     :|..|.:.|    ::
Mouse   234 LCE---MEGCRLRVQELEAELLE-----------LQQMKQAKTYL-----LAREEHLAE----AL 275

  Fly   318 LSESTSKCDNSGADYKERFRIPE--DLNPNSSDKPNPYRDLVEKYEA----LVEVKRTSNAVKSN 376
            |:..|              :.||  |..|.|.|..|. :|.|....|    .|....:..|:.:.
Mouse   276 LAPLT--------------QAPEADDPQPGSGDDSNA-QDGVSSPAASPSHAVRKSCSDTALNAI 325

  Fly   377 FTSNPDGK-----TMTESSQGKKSETIVNSSKES--------DLMLDSTRKRTPTEFSESETTSS 428
            ...:|..:     |:..:|..::..:|:....|.        :.:|...|:...........||.
Mouse   326 VAKDPASRHAGNLTLHANSVRRRGMSILREVDEQYHALLEKYEELLSKCRQHGAGVRHAGVQTSR 390

  Fly   429 GFSDETSNKSTQTDERPSYFLCSISNGNDCKFSIYDDVSPIESHF-RNRPEYRELFKEIFGVLKK 492
            ..|.::|.:.....|.      |...|...:.|:...|..::... :::|||:.||||||..::|
Mouse   391 PISRDSSWRDLLGGEE------SPGEGKAGEKSLSQHVEAVDKRLEQSQPEYKALFKEIFARIQK 449

  Fly   493 A-ADNN 497
            . ||.|
Mouse   450 TKADIN 455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cen	NP_610049.1	SMC_prok_B	<13..>255	CDD:274008	75/254 (30%)
Cdr2l	NP_001074398.1	Smc	<2..>238	CDD:224117	80/266 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	282..315		11/33 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	382..421		8/44 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849808
Domainoid	1	1.000	95	1.000	Domainoid score	I7405
eggNOG	1	0.900	-	-		E1_2C4BD
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	95	1.000	Inparanoid score	I5045
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1101523at2759
OrthoFinder	1	1.000	-	-		FOG0003445
OrthoInspector	1	1.000	-	-		otm42372
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19232
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5462
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.890