Protein Alignment Cen and CDR2

DIOPT Version :10

• Sequence 1: NP_610049.1
• Gene: Cen / 35330
• FlyBaseID: FBgn0032876
• Length: 790
• Species: Drosophila melanogaster
• Sequence 2: NP_001793.1
• Gene: CDR2 / 1039
• HGNCID: 1799
• Length: 454
• Species: Homo sapiens
• Alignment Length: 537
• Identity: 122/537 - (22%)
• Similarity: 204/537 - (37%)
• Gaps: 165/537 - (30%)

  Fly    16 QFMLDDLQLAAELGKTLLERNKELETFIKEYKIKGDEQELEILHLRKHINAMTEVNDSRLKVYEQ 80
            |.:..|||||||||||||:||.|||..:::......||..||.:|.|.:..:.::|:...|||||
Human    22 QDLQQDLQLAAELGKTLLDRNTELEDSVQQMYTTNQEQLQEIEYLTKQVELLRQMNEQHAKVYEQ 86

  Fly    81 LEVGIQDLERANQRLNLEKNRDKKQIKTLTTNTEVLEARCEELSQLLSDARQSLSTERR--KVDQ 143
            |:|..::||..||:|..:....:::|.:||...|.|:...:.|...:.:.:.|....|.  |.||
Human    87 LDVTARELEETNQKLVADSKASQQKILSLTETIECLQTNIDHLQSQVEELKSSGQGRRSPGKCDQ 151

  Fly   144 YQ--------QERYRM-QHSTEGSVSSHSIQSLCKEQSVEFSKLDVMAIANSTGLEDISFSNATM 199
            .:        :|.|.: ||.....|.:..|.||..:.|.:
Human   152 EKPAPSFACLKELYDLRQHFVYDHVFAEKITSLQGQPSPD------------------------- 191

  Fly   200 CERTAVKGEDNEELVKLLSEMEVLKRDFLAEQQRCTELEEQLVTIIQDNQGLQTRL--------- 255
                   .|:||.|.|.::   :|:.....|:|:...:||:...::::|..|:.:|
Human   192 -------EEENEHLKKTVT---MLQAQLSLERQKRVTMEEEYGLVLKENSELEQQLGATGAYRAR 246

  Fly   256 ---LENSANEGTMSMHEEFSLLDDVRQGQMCSRCLRDINESNTNMDDQSSIAPTEEIYEDDDRSI 317
               ||....|....:..|...::.|.:                 :...|...|    :::..:|:
Human   247 ALELEAEVAEMRQMLQSEHPFVNGVEK-----------------LVPDSLYVP----FKEPSQSL 290

  Fly   318 LSESTSKCDNSGADYKERFRIPEDLNPNSSDKPNPYRDLVEKYEALVEVKRTSNAVKSNFTSNPD 382
            |.|..             ..:||     |..||               :||:|
Human   291 LEEMF-------------LTVPE-----SHRKP---------------LKRSS------------ 310

  Fly   383 GKTMTESSQGKKSETIVNSSKESDLM----------LDSTRKRTPTEFSESETTSSGF------- 430
                        ||||::|...||::          ..:.::|..:...|.:|..|..
Human   311 ------------SETILSSLAGSDIVKGHEETCIRRAKAVKQRGISLLHEVDTQYSALKVKYEEL 363

  Fly   431 -------SDETSNKSTQTDERPSYFLCSISNGNDCKFSIYDDVS----PIESHFRNRPEYRELFK 484
                   .|..|:|:.||....:..|..::..::...|.::..|    |:.|. ...|||:.|||
Human   364 LKKCQEEQDSLSHKAVQTSRAAAKDLTGVNAQSEPVASGWELASVNPEPVSSP-TTPPEYKALFK 427

  Fly   485 EIFGVLKKAADNNEEDK 501
            |||..:||.....:|.:
Human   428 EIFSCIKKTKQEIDEQR 444

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cen	NP_610049.1	SMC_prok_B	<30..>270	CDD:274008	64/262 (24%)
CDR2	NP_001793.1	SMC_prok_B	<8..>263	CDD:274008	74/275 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	134..153		5/18 (28%)