DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cen and cdr2b

DIOPT Version :9

Sequence 1:	NP_610049.1	Gene:	Cen / 35330	FlyBaseID:	FBgn0032876	Length:	790	Species:	Drosophila melanogaster
Sequence 2:	XP_005169488.1	Gene:	cdr2b / 101886304	ZFINID:	ZDB-GENE-101203-4	Length:	563	Species:	Danio rerio

Alignment Length:	605	Identity:	129/605 - (21%)
Similarity:	217/605 - (35%)	Gaps:	201/605 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 DLQLAAELGKTLLERNKELETFIKEYKIKGDEQELEILHLRKHINAMTEVNDSRLKVYEQLEVGI 85
            ||.|||||||.|||:|:|||..|::..|...||..||.:|.|.::.:..|:|...|:||||:...
Zfish    27 DLHLAAELGKNLLEQNRELEETIQQMYITNQEQMQEIEYLSKQVDLLRSVSDQHAKLYEQLDASS 91

  Fly    86 QDLERANQRLNLEKNRDKKQIKTLTTNTEVLEARCEELS-----------------QLLSDARQS 133
            |:||..||:|..|....:.:|:.||...:.|:...|||.                 .|..|.|..
Zfish    92 QELELKNQKLTQENRAAQIKIQGLTETVDGLQTHVEELQTDLQKMKQIAEEHKLCRSLRDDQRGK 156

  Fly   134 LSTER-----------RKVDQYQQERYRMQHSTEGSVSSHSIQSLCKEQSV--EFSKLDVMAIAN 185
            .::.|           |:..:.|::|..:|.|.      ||:|:..:.:..  |.::|.|
Zfish   157 CASRRSCVSQESWVCSRRCSEPQEQREELQRSL------HSLQAQLRSECALRESAELQV----- 210

  Fly   186 STGLEDISFSNATMCERTAVKGEDNEELVKLLSEMEVLK-------------------------R 225
                ||:......:..|.|:..|..|.|.::.:|.:.|:                         .
Zfish   211 ----EDLMLQIRLLEPRAALVEEYEERLQEVQAEAQELRLHSSTHTPSLEEGGAWQKGWSLHQDM 271

  Fly   226 DFLAEQQRCTELEEQLVTIIQDNQGLQTRLLENSANEG-------------------------TM 265
            ..|..:....||..:.:.|:.|..|:..::.:.....|                         .|
Zfish   272 SLLDNEVGVVELRGRRLPILDDEVGVLAQIDDEVGVVGQRGWSLPMPDDEVGVVKQKGRRLHKDM 336

  Fly   266 SM----------------HEEFSLLDD----VRQGQMCSRCLRD-----INESNTNMDDQSSIAP 305
            ||                |:..|||.|    :.|....|.||.|     :.:|..|:..|..
Zfish   337 SMLDYEVGVVQQKGRSLKHQALSLLADEVGVMGQNLQQSWCLLDEEVDVVGQSGRNLQHQGG--- 398

  Fly   306 TEEIYEDDDRSILSESTSKCDNSGADYKERFRIPE-DLNPNSSDKPNPYRDLVEKYEALV--EVK 367
                      |:|::.......||....:...:.| |:..:|.      |.|..:..::.  ||:
Zfish   399 ----------SLLNDGVGVVTQSGGGLYQGVYLDEWDVVGHSG------RSLQHQAASIQDDEVR 447

  Fly   368 RTSNAVKSNFTSNP---DGKTMTE------SSQGKKSETIVNS-----SKESDLMLDSTRKRTPT 418
            ..|.:.:......|   ||..:.:      ..||....:.|::     .::.|.:|...:..|||
Zfish   448 VVSPSGRGLHNGMPLLDDGVGVVKHRGRGLQHQGASLLSEVDAQYVALQEKYDALLRRCQSDTPT 512

  Fly   419 EFSESETTSSGFSDETSNKSTQTDERPSYFLCSISNGNDCKFSIYDDVSPIESH--FRNRPEYRE 481
            .                |::|                           .|..:|  ...:|||:.
Zfish   513 H----------------NQNT---------------------------VPTHTHSTHNQQPEYKA 534

  Fly   482 LFKEIFGVLKKAADNNEEDK 501
            ||:|||..::|:.::.:|::
Zfish   535 LFQEIFTFIQKSKEDLKENR 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cen	NP_610049.1	SMC_prok_B	<13..>255	CDD:274008	75/288 (26%)
cdr2b	XP_005169488.1	DUF1043	30..120	CDD:299736	39/89 (44%)
cdr2b	XP_005169488.1	Ufd2P_core	<133..>208	CDD:287392	13/80 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595609
Domainoid	1	1.000	122	1.000	Domainoid score	I5592
eggNOG	1	0.900	-	-		E1_2C4BD
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	122	1.000	Inparanoid score	I4721
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1101523at2759
OrthoFinder	1	1.000	-	-		FOG0003445
OrthoInspector	1	1.000	-	-		otm25719
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19232
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.950