Protein Alignment IKKepsilon and Ikbkb

DIOPT Version :10

• Sequence 1: NP_610048.2
• Gene: IKKepsilon / 35329
• FlyBaseID: FBgn0086657
• Length: 720
• Species: Drosophila melanogaster
• Sequence 2: XP_063131856.1
• Gene: Ikbkb / 84351
• RGDID: 621375
• Length: 823
• Species: Rattus norvegicus
• Alignment Length: 800
• Identity: 170/800 - (21%)
• Similarity: 305/800 - (38%)
• Gaps: 231/800 - (28%)

  Fly    12 WCTTSVLGKGATGSVFQGVNKITGESVAVKTFNPYSHMRPADVQMREFEALKKVNHENIVKLLAI 76
            |.....||.|..|:|.:..|::|||.:|:|........:..|....|.:.::::||.|:|....:
  Rat    15 WEMKERLGTGGFGNVIRWHNQVTGEQIAIKQCRQELSPKNRDRWCLEIQIMRRLNHPNVVAARDV 79

  Fly    77 EEDQEGRG----KVIVMELCTGGSLFNILDDPENSYGLPEHEFLLVLEHLCAGMKHLRDNKLVHR 137
            .|..:...    .::.||.|.||.|...|:..||..||.|...|.:|..:.:.:::|.:|:::||
  Rat    80 PEGMQNLAPNDLPLLAMEYCQGGDLRRYLNQFENCCGLREGAILTLLSDIASALRYLHENRIIHR 144

  Fly   138 DLKPGNIMKFISEDGQ--TIYKLTDFGAARELEDNQPFASLYGTEEYLHPDLYERAVLRKSIQRS 200
            ||||.||   :.:.|:  .|:|:.|.|.|:||:......|..||.:||.|:|.|        |:.
  Rat   145 DLKPENI---VLQQGEKRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPELLE--------QQK 198

  Fly   201 FTANVDLWSIGVTLYHVATGNLPFRPFGGRKNRETMH-QITTKKASGVISGTQLSENGPIEWSTT 264
            :|..||.||.|...:...||   ||||.........| ::..|....::....|  ||.:::|::
  Rat   199 YTVTVDYWSFGTLAFECITG---FRPFLPNWQPVQWHSKVRQKSEVDIVVSEDL--NGTVKFSSS 258

  Fly   265 LPPHAHLSQGLKTLVTPLLAGLLEENREK------TW-----------SFDRFFHEVTLILRKRV 312
            ||...:|:            .:|.|..||      ||           ..:..|..:..||..::
  Rat   259 LPFPNNLN------------SVLAERLEKWLQLMLTWQPRQRGVDPQYGPNGCFRALDDILNLKL 311

  Fly   313 IHVFFTNRTSSVEVF-LEPDEQIDNFRERI-----FLQTEVPLEKQ------------------- 352
            :|: ....|.::..: :..||.:.:.:.||     .|:|:..|.::
  Rat   312 VHI-LNMVTGTIHTYPVMEDESLQSLKTRIREDTGILETDQELLQEAGLVLLPDKPATQCISDSK 375

  Fly   353 -----------ILLFNNEHL--EKKVTPRTIAKAFPATTTD------------------QPIFLY 386
                       :.||:|..:  |.::|||...::......:                  ..|...
  Rat   376 TNEGLTLDMDLVFLFDNSKMSYETQITPRPQPESVSCVLQEPKRNLSFFQMRKVWGQVWHSIQTL 440

  Fly   387 SNDDNNVQLPQQLDLPKFPVFPPNVSVENDASLAK---SACSVGHECKRRVDIF-TSMDILIKKG 447
            ..|.|.:|..|:..:...        :.|::.|:|   :..|...:.|.::|.| ||:.|.::|.
  Rat   441 KEDCNRLQQGQRAAMMNL--------LRNNSCLSKMKNAMASTAQQLKAKLDFFKTSIQIDLEKY 497

  Fly   448 VEHFIEMLVTTITLLLKKTESFDNLLSTVIDYADVVHSMARVTKGDQEIKTLLTALENVKSDFDG 512
            .|. .|..:|:           |.||....:....|....|    :.::|.|:..:..:::|
  Rat   498 REQ-TEFGITS-----------DKLLLAWREMEQAVEQCGR----ENDVKVLVERMMALQTD--- 543

  Fly   513 AADVISQMHKHFVIDDELNDQWTSSMHGKKCPCKTRASAQAKYLVERLRDSWQHLLRDRATRTLT 577
                             :.|...|.|..|:.........||:.|..|||:.    .||:.|.
  Rat   544 -----------------IVDLQRSPMGRKQGGTLDDLEEQARELYRRLREK----PRDQRTE--- 584

  Fly   578 YNDEQ------FHALEKIKVDHNGKRIKALLLDNVNPTVAQIAECLADWYKLAQTVYLKTQILE- 635
             .|.|      ..|::..:     |:::.:                  :.:|::||..|.:.||
  Rat   585 -GDSQDMVRLLLQAIQSFE-----KKVRVI------------------YSQLSKTVVCKQKALEL 625

  Fly   636 -KDVRDCERKLNGIRDELYHVKSELKLDVDTKTINNNNQLAKIEERNRLRVMQQQQQEVMAVMRT 699
             ..|.:..|.:|                .|.||:              :|:.:::|:|:..:::
  Rat   626 LPKVEEVVRLMN----------------EDEKTV--------------VRLQEKRQKELWNLLK- 659

  Fly   700 NSDIISLLSKLGITNGSLES 719
                |:.....|..:||.:|
  Rat   660 ----IACSKVRGPVSGSPDS 675

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IKKepsilon	NP_610048.2	STKc_TBK1	18..332	CDD:270890	91/338 (27%)
		Ubl_TBK1_like	310..388	CDD:340518	17/133 (13%)
		TBK1_CCD1	405..656	CDD:465742	48/262 (18%)
Ikbkb	XP_063131856.1	None