DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment IKKepsilon and Tbk1

DIOPT Version :9

Sequence 1:	NP_610048.2	Gene:	IKKepsilon / 35329	FlyBaseID:	FBgn0086657	Length:	720	Species:	Drosophila melanogaster
Sequence 2:	NP_062760.3	Gene:	Tbk1 / 56480	MGIID:	1929658	Length:	729	Species:	Mus musculus

Alignment Length:	751	Identity:	271/751 - (36%)
Similarity:	427/751 - (56%)	Gaps:	68/751 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LRGSVSYVWCTTSVLGKGATGSVFQGVNKITGESVAVKTFNPYSHMRPADVQMREFEALKKVNHE 68
            ::.:.:::|..:.:||:|||.:||:|.:|.||:..|||.||..|.:||.||||||||.|||:||:
Mouse     1 MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLYAVKVFNNISFLRPVDVQMREFEVLKKLNHK 65

  Fly    69 NIVKLLAIEEDQEGRGKVIVMELCTGGSLFNILDDPENSYGLPEHEFLLVLEHLCAGMKHLRDNK 133
            |||||.||||:...|.||::||.|..|||:.:|::|.|:|||||.|||:||..:..||.|||:|.
Mouse    66 NIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 130

  Fly   134 LVHRDLKPGNIMKFISEDGQTIYKLTDFGAARELEDNQPFASLYGTEEYLHPDLYERAVLRKSIQ 198
            :||||:||||||:.|.||||::||||||||||||||::.|.||||||||||||:||||||||..|
Mouse   131 IVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRKDHQ 195

  Fly   199 RSFTANVDLWSIGVTLYHVATGNLPFRPF-GGRKNRETMHQITTKKASGVISGTQLSENGPIEWS 262
            :.:.|.|||||:|||.||.|||:|||||| |.|:|:|.|::|.|.|.||.|||.|.:|||||:||
Mouse   196 KKYGATVDLWSVGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAISGVQKAENGPIDWS 260

  Fly   263 TTLPPHAHLSQGLKTLVTPLLAGLLEENREKTWSFDRFFHEVTLILRKRVIHVFFTNRTSSVEVF 327
            ..:|....|||||:.|:||:||.:||.::||.|.||:||.|.:.:|.:.|||||.....::.:::
Mouse   261 GDMPLSCSLSQGLQALLTPVLANILEADQEKCWGFDQFFAETSDVLHRMVIHVFSLQHMTAHKIY 325

  Fly   328 LEPDEQIDNFRERIFLQTEVPLEKQILLFNNEHLEKKVTPRTIAKAFPATTTDQPIFLYSNDD-N 391
            :........|.|.::.||::....|.|::....|..::  ..:|:.||.||.:.|||:.|.:. |
Mouse   326 IHSYNTAAVFHELVYKQTKIVSSNQELIYEGRRLVLEL--GRLAQHFPKTTEENPIFVTSREQLN 388

  Fly   392 NVQLP-QQLDLPKFPVFPPNVSVENDASLAKSACSVGHECKRRVDIFTSMDILIKKGVEHFIEM- 454
            .|.|. :::.|||   ..|...::.|||:||:...|.....|..........|::|||...:|:
Mouse   389 TVGLRYEKISLPK---IHPRYDLDGDASMAKAVTGVVCYACRTASTLLLYQELMRKGVRWLVELV 450

  Fly   455 -------------LVTTITLLLKKTES----FDNLLSTVIDYADVVHSMARVTKGD-QEIKTLLT 501
                         :|.|:...::..|.    ::.|:...::.|::         |: .:|.|.|.
Mouse   451 KDDYNETVHKKTEVVITLDFCIRNIEKTVKVYEKLMKVNLEAAEL---------GEISDIHTKLL 506

  Fly   502 ALENVKSDFDGA-ADVISQMHKHFVIDDELNDQWTSSMHGKKCPCKTRASAQAKYLVERLRDSWQ 565
            .|.:.:...:.: .|:.|::....:    |.|.|.   |.:....:.|...:.:.|:..:.:.:.
Mouse   507 RLSSSQGTIESSLQDISSRLSPGGL----LADTWA---HQEGTHPRDRNVEKLQVLLNCITEIYY 564

  Fly   566 HLLRDRATRTLTYNDEQFHALEKIKVDHNGKRIKALLLDNVNPTVAQIAECLADWYKLAQTVYLK 630
            ...:|:|.|.|.||:||.|..:|.|:.::..:..:...:..........:...:|  :.:.::|:
Mouse   565 QFKKDKAERRLAYNEEQIHKFDKQKLYYHATKAMSHFSEECVRKYEAFKDKSEEW--MRKMLHLR 627

  Fly   631 TQILE--KDVRDCERKLNGIRDELYHVKSELKLDVDTKTI--------------NNNNQLAKIEE 679
            .|:|.  ....|.|.:::..:|    ..:||:..:..|.:              .::|.|  :|.
Mouse   628 KQLLSLTNQCFDIEEEVSKYQD----YTNELQETLPQKMLAASGGVKHAMAPIYPSSNTL--VEM 686

  Fly   680 RNRLRVMQQQQQEVMAVMRTNSDIISLLSKLGITNG 715
            ...::.::::.:.|:..:..|:.|:.....|.:..|
Mouse   687 TLGMKKLKEEMEGVVKELAENNHILERFGSLTMDGG 722

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IKKepsilon	NP_610048.2	Pkinase	16..297	CDD:278497	177/281 (63%)
		STKc_TBK1	18..332	CDD:270890	188/314 (60%)
		UBL_TBK1_like	299..389	CDD:240618	25/89 (28%)
Tbk1	NP_062760.3	S_TKc	9..242	CDD:214567	148/232 (64%)
		STKc_TBK1	15..330	CDD:270890	188/314 (60%)
		UBL_TBK1_like	297..385	CDD:240618	25/89 (28%)
		Interaction with AZI2, TANK and TBKBP1. /evidence=ECO:0000250\|UniProtKB:Q9UHD2	621..729		17/108 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846707
Domainoid	1	1.000	303	1.000	Domainoid score	I1392
eggNOG	1	0.900	-	-		E2759_KOG4250
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H22742
Inparanoid	1	1.050	461	1.000	Inparanoid score	I1549
Isobase	1	0.950	-	0	Normalized mean entropy	S3798
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D257949at33208
OrthoFinder	1	1.000	-	-		FOG0002906
OrthoInspector	1	1.000	-	-		otm43650
orthoMCL	1	0.900	-	-		OOG6_105248
Panther	1	1.100	-	-	O	PTHR22969
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5178
SonicParanoid	1	1.000	-	-		X2267
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	15	14.780