Protein Alignment IKKepsilon and ikbkb

DIOPT Version :9

• Sequence 1: NP_610048.2
• Gene: IKKepsilon / 35329
• FlyBaseID: FBgn0086657
• Length: 720
• Species: Drosophila melanogaster
• Sequence 2: NP_001116737.1
• Gene: ikbkb / 563560
• ZFINID: ZDB-GENE-071115-2
• Length: 779
• Species: Danio rerio
• Alignment Length: 820
• Identity: 169/820 - (20%)
• Similarity: 297/820 - (36%)
• Gaps: 276/820 - (33%)

  Fly    12 WCTTSVLGKGATGSVFQGVNKITGESVAVKTFNPYSHMRPADVQMREFEALKKVNHENIVKLLAI 76
            |.....||.|..|:|....||.|...:|:|.......::.......|.:.:|::.|.|:|....:
Zfish    15 WELKERLGTGGFGNVTLWQNKETSIQIAIKQCRQELSVKNKGRWSLEIQIMKRLTHMNVVAARDV 79

  Fly    77 EEDQEGRG----KVIVMELCTGGSLFNILDDPENSYGLPEHEFLLVLEHLCAGMKHLRDNKLVHR 137
            .|:.:...    .::.||.|.||.|...|:..||..|:.|...|.:::.:.:.:.:|...:::||
Zfish    80 PEELQKLATNDLPLLAMEFCQGGDLRKYLNLVENCCGMREAAVLTLIQDISSALTYLHGMRIIHR 144

  Fly   138 DLKPGNIMKFISEDGQ--TIYKLTDFGAARELEDNQPFASLYGTEEYLHPDLYERAVLRKSIQRS 200
            ||||.||   :.:.|:  .::|:.|.|.|:||:.:....|..||.:||.|:|.|        |:.
Zfish   145 DLKPENI---VLQQGEKRLVHKIIDLGYAKELDQSSLCTSFVGTLQYLAPELLE--------QQK 198

  Fly   201 FTANVDLWSIGVTLYHVATGNLPFRPFGGRKNRETMH-QITTKKASGVISGTQLSENGPIEWSTT 264
            :|..||.||.|..::...||   ||||.........| ::..|....::....|  .|.:.:|..
Zfish   199 YTVAVDYWSFGTLVFECITG---FRPFLPTWQPVQWHSKLQQKHVDDIVVYEDL--GGEVRYSKH 258

  Fly   265 LP-PHAHLSQGLKTLVTPLLAGLL----------------------------------EENREKT 294
            || ||.         :..||||.|                                  ||::|.:
Zfish   259 LPNPHN---------LNKLLAGELERWLQMMLRWSPKERGKDLKQRNKESQETPKDAEEESKETS 314

  Fly   295 ------------WSFDRFFHEVTLILRKRVIHVFFTNRTSSVEVF---LEPDEQIDNFRERIFLQ 344
                        :.||...|    ||..:::||.  |.||: |:|   ::|::.:.:.:|||...
Zfish   315 PEGAKDAPKAPCFCFDELSH----ILNLKLVHVL--NMTSA-EIFNYSVQPEDDVASLQERIAQD 372

  Fly   345 TEVP-------------LEKQ----------------------ILLFNNE--HLEKKVTPRTIAK 372
            |.:|             ||.|                      :.||:..  ..|.:.|||.:.:
Zfish   373 TGIPPANQELLLEAGLALEPQNSVMQCAIDYSLMDNRRADEPLVFLFDRSCCSYEPQFTPRVLPE 437

  Fly   373 --AFPATTTDQPIFLYSN-----------------DDNNVQLPQQLDLPKFPVFPPNVSVENDAS 418
              .|......:|: .||:                 |...:|..|::.:...        :.::.:
Zfish   438 NIRFVQNEPKRPL-PYSSQRRTWGQAWHTIRALKEDWQRLQQGQKVAIMSL--------LRHNGT 493

  Fly   419 LAK---SACSVGHECKRRVDIF-TSMDILIKKGVEHFIEMLVTTITLLLKKTESFDNLLS----- 474
            |:|   ...|:....|..:|.| .|:.:.|.|    :.|...|.|        :.:.|||
Zfish   494 LSKQKNEMVSMHQRLKATLDFFGASLHVDISK----YQEQRATGI--------ASEKLLSVWREM 546

  Fly   475 --TVIDYADVVHSMARVTKGDQEIKTLLT--------------ALENVK---------------- 507
              |.:|....    ..|.|.::|:.||.|              |||.::
Zfish   547 EQTALDCGQT----EDVFKLEEEMMTLQTDIVDLQRQPWRSGEALETLEVKAMELFRKLREKPRE 607

  Fly   508 ----SDFDGAADVISQMHKHFVIDDELNDQWTSSMH-GKKCPCKTR-----------ASAQAK-- 554
                .|......::.|..:.:  :.:|.|.:|   | .|...|:.|           .||.|:
Zfish   608 QRSMGDCQEVIKLVVQAVQFY--ERKLRDFYT---HLSKTMVCRQRVLALLPRVEGLVSAMARSE 667

  Fly   555 ----YLVERLRDSWQHLLRDRATRTLT-----------------------------------YND 580
                :|.|:.:....:||:...::..:                                   :.:
Zfish   668 KQLLHLQEKRQKELWNLLKVACSKVRSPVSGSPDGGRTPPAPTPQLMSHRPSHPSSPPSDGPHTE 732

  Fly   581 EQFHALEKIKVDHNGKRIKALLLDNVNPTVAQIAECLADW 620
            |..|.:|:.::..|  |:::|:.|.:..|.:.: :.|.:|
Zfish   733 ESLHVIEESRIFEN--RLQSLVQDTIQETESSM-QILREW 769

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IKKepsilon	NP_610048.2	Pkinase	16..297	CDD:278497	82/334 (25%)
		STKc_TBK1	18..332	CDD:270890	95/370 (26%)
		UBL_TBK1_like	299..389	CDD:240618	29/148 (20%)
ikbkb	NP_001116737.1	STKc_IKK_beta	20..338	CDD:270940	87/346 (25%)
		TGS	329..>380	CDD:330245	18/57 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4250
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	3	2.770