DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment IKKepsilon and IKKbeta

DIOPT Version :9

Sequence 1:	NP_610048.2	Gene:	IKKepsilon / 35329	FlyBaseID:	FBgn0086657	Length:	720	Species:	Drosophila melanogaster
Sequence 2:	NP_524751.3	Gene:	IKKbeta / 44432	FlyBaseID:	FBgn0024222	Length:	717	Species:	Drosophila melanogaster

Alignment Length:	791	Identity:	188/791 - (23%)
Similarity:	297/791 - (37%)	Gaps:	194/791 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 WCTTSVLGKGATGSVFQGVNKITGESVAVKTFNPYSHMR-----PADVQMREFEALKK------- 64
            |.....||:|..|.|....|:.||..:|.|      |::     .||.|::..|...|
  Fly     7 WERCRNLGEGGFGLVIHWRNRTTGREIATK------HIKEMGALSADQQVKLSERWNKELNWSRQ 65

  Fly    65 -VNHENIVKLLAIEEDQ---------EGRGKVIVMELCTGGSLFNILDDPENSYGLPEHEFLLVL 119
             .|..:||..:.||:..         ..:..|||:|.|.||.:...|..|||:.||.|.|...:|
  Fly    66 FKNFPHIVAGVDIEDPDFLEYLNGMFSAKLPVIVLEYCNGGDVRKRLQSPENANGLTEFEVRQIL 130

  Fly   120 EHLCAGMKHLRDN-KLVHRDLKPGNIMKFISEDGQTIYKLTDFGAARELEDNQPFASLYGTEEYL 183
            ..|...:..|... .:.||||||.||:.....||:.||||||||.||...|.....|:.||..|.
  Fly   131 GALRKALHFLHSQCGICHRDLKPDNIVIQRGVDGKKIYKLTDFGLARGTPDQTMVQSVVGTRHYY 195

  Fly   184 HPDLYERAVLRKSIQRSFTANVDLWSIGVTLYHVATGNLPFRPFGGRKNRETMHQITTKKASGVI 248
            .|::.|...        :.:.|||||.||..|.:.||.|||.|....||  .:..:..|.|..:.
  Fly   196 APEVVENGF--------YNSTVDLWSFGVIAYELVTGELPFIPHQTLKN--IILNLIKKPAKCIA 250

  Fly   249 SGTQLSENGPIEWSTTLPPHAHLS-----QGLKTLVTPLLAGLLEENREKTWSFDRFFHEVTLIL 308
            ......:|........||...|||     |..|.|.:||.:...|..:....:....|.::..||
  Fly   251 ITEDPEDNTRFVNQFELPQTHHLSRPWAAQFTKWLASPLNSNYKERGQLAANNVPVVFADLDKIL 315

  Fly   309 RKRVIHVFFTNRTSSVEVFLEPDEQIDNFRERIFLQTEVPLEKQILLFNNEHLEKKVTPRT---- 369
            ...|:.:|..|....:|..:..:..:.:....|.|.|.:..::...:....|..|.:||::
  Fly   316 NMNVLTIFAVNNCERLEYAVSAEMTMKDLIALIVLDTGMDEKELYFVLPTSHPHKTITPKSTPLQ 380

  Fly   370 -IAKAFPATTTDQ---------PIFLYSNDDNNVQLPQQLDLPKFPVFPPNVSVENDASLAKSAC 424
             ..:.:..|:.|.         |:.||.     .|:.::.|. |.|  .|.:|:.:...:|....
  Fly   381 LYVEEWSDTSKDSRKWTKRSNPPVMLYI-----FQVKKECDY-KIP--EPILSILSRKFIANKFK 437

  Fly   425 SVGHECKRRVDIFTSMDILIKKGVEHFIEMLVTTIT--LLLKKTESFDNLLSTVIDYADVVHSMA 487
            :.....::|| :...:.:|.|:...:  ||||:.|.  .|..:.|..:|.....||...::.|.|
  Fly   438 TKERWLQKRV-VLDMLYVLTKEQARY--EMLVSGINERALSLEDEMMENSFIDSIDKQRIIISFA 499

  Fly   488 RVTKGDQEIKTLLTALENVKSDFDGAADVISQMHKHFVIDDELNDQWTSSMHGKKCPCKTRASAQ 552
                                                       .||.||.:          ..||
  Fly   500 -------------------------------------------YDQLTSLL----------KEAQ 511

  Fly   553 AKYLVERLRDS--WQHLLRDRATRTLTYNDEQFHALEKIKVDHNGKRIKALLLDNVNPTVAQIAE 615
            ||....:|..|  |:.|.|:       ||          .:..:.|.|::.|           ..
  Fly   512 AKIPSRQLISSAQWEKLNRN-------YN----------FIIQSAKSIRSFL-----------EA 548

  Fly   616 CLADWYKLAQTV-YLKTQILEKDVRDCER---------------KLNGIRDELYHVKSELKLDVD 664
            ||.:...:.:|. .|:.::.|||:.||.|               :||...:|.  .||..||..:
  Fly   549 CLREAKDMVKTTNQLRKEVCEKDLFDCARFYKKYLCNGAIISPSELNNDAEEF--AKSRFKLYNE 611

  Fly   665 ------TKTINNNNQLAKIEERNRLRVMQQQ---------QQEVMAVMRTNS------DIISLLS 708
                  .|:|::.:.| ..:.:..:.|:.||         |..:..:|..:|      ::.:.:.
  Fly   612 GEARHLPKSIDHMHYL-YFKTKESIPVLLQQFCDIKKEIFQINLQMLMSASSTPPPKLELSAAMD 675

  Fly   709 KLGITNGSLES 719
            :|.|::||..|
  Fly   676 RLAISSGSPSS 686

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IKKepsilon	NP_610048.2	Pkinase	16..297	CDD:278497	96/308 (31%)
		STKc_TBK1	18..332	CDD:270890	103/341 (30%)
		UBL_TBK1_like	299..389	CDD:240618	19/103 (18%)
IKKbeta	NP_524751.3	S_TKc	7..245	CDD:214567	83/253 (33%)
IKKbeta	NP_524751.3	PKc_like	13..316	CDD:304357	98/318 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45463164
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4250
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR22969
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840