DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment IKKepsilon and ikbke

DIOPT Version :9

Sequence 1:	NP_610048.2	Gene:	IKKepsilon / 35329	FlyBaseID:	FBgn0086657	Length:	720	Species:	Drosophila melanogaster
Sequence 2:	NP_001002751.1	Gene:	ikbke / 437024	ZFINID:	ZDB-GENE-040718-251	Length:	721	Species:	Danio rerio

Alignment Length:	750	Identity:	266/750 - (35%)
Similarity:	400/750 - (53%)	Gaps:	83/750 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LRGSVSYVWCTTSVLGKGATGSVFQGVNKITGESVAVKTFNPYSHMRPADVQMREFEALKKVNHE 68
            :..:.:|:|....:||:|||.:|::..||.|||.||||.||..|:.||.:|||||||.|:.:||.
Zfish     1 MTSTANYLWSQEDILGQGATANVYKARNKKTGELVAVKVFNLVSYNRPYEVQMREFEVLQLLNHV 65

  Fly    69 NIVKLLAIEE-DQEGRGKVIVMELCTGGSLFNILDDPENSYGLPEHEFLLVLEHLCAGMKHLRDN 132
            |||||.|:|| ....:.|::|||.|:||||.|:|:.||:::||||.|||:||..:..||.|||:|
Zfish    66 NIVKLFAVEEIISNPKQKILVMEYCSGGSLLNMLEQPEHAFGLPESEFLIVLHCVAHGMNHLREN 130

  Fly   133 KLVHRDLKPGNIMKFISEDGQTIYKLTDFGAARELEDNQPFASLYGTEEYLHPDLYERAVLRKSI 197
            .:||||:||||||:.:.|||:::|||.||||||||||::.|.|:||||||||||:|||||||...
Zfish   131 SVVHRDIKPGNIMRQVGEDGRSVYKLADFGAARELEDDEKFVSIYGTEEYLHPDMYERAVLRSPQ 195

  Fly   198 QRSFTANVDLWSIGVTLYHVATGNLPFRPFGG-RKNRETMHQITTKKASGVISGTQLSENGPIEW 261
            |:::..:|||||||||:||:|||:|||||||| |||::.||:|||:|.:|.|:|.|..|:|||||
Zfish   196 QKAYGVSVDLWSIGVTIYHMATGSLPFRPFGGPRKNKQMMHKITTEKPAGTIAGVQKEEDGPIEW 260

  Fly   262 STTLPPHAHLSQGLKTLVTPLLAGLLEENREKTWSFDRFFHEVTLILRKRVIHVFFTNRTSSVEV 326
            ...||....||:||||.:.|:||.:|..:.||.|.|.:||.....||.:..|::|...:.::..:
Zfish   261 RDKLPLSCQLSEGLKTQLVPVLANILLADDEKCWKFPQFFSATNDILNRITIYIFSLQQATTYSI 325

  Fly   327 FLEPDEQIDNFRERIFLQTEVPLEKQILLFNNEHLEKKVTPRTIAKAFPATTTDQPIFLYSNDDN 391
            :::....:..|.|.:..||.:....|..||....|  .:.|.......|.|::|:|:.|.|....
Zfish   326 YIQFHNTVSIFFEDVQAQTGIEPAAQQYLFQGHPL--ILDPSMKVVNIPHTSSDKPMILISRRLE 388

  Fly   392 NVQLPQQLDLPKFPVFPPNVSVENDASLAKSACSVGHECKRRVDIFTSMDILIKKGVEHFIEMLV 456
            .: :....:.|:.|..|....|..|....|:...|.|:..|           |...::.:.:.::
Zfish   389 RI-IGYPFEEPESPPMPGKFDVVADFVFTKTIVKVIHQYLR-----------IAYSLQEYRQFIL 441

  Fly   457 TTITLLLKKTESFDNLLSTVIDYADVVHSMARV-TKGDQEI---KTLLTALENVKSDFDGAADVI 517
            ......:::|.|         :..||.|.:::| .|....|   |||....:....:|   .|.|
Zfish   442 QGFNSYIEQTSS---------EVIDVAHRISKVKMKLHSSISTEKTLHVFTQTFAHEF---PDFI 494

  Fly   518 SQMHKHFVIDDELND----------------QWTSSMHGKKCPCKTRASAQAKYLVERLRDSWQH 566
            ....|..:|:.||..                :.|.|.|.:.. ...::..:.:.|:.::.|....
Zfish   495 DSKKKFPLIEAELQHMCGRGIREFQNILQYLRVTLSKHSETL-ANDKSIQKMEVLLSQIVDVHFQ 558

  Fly   567 LLRDRATRTLTYNDEQFHALEKIKVDHNGKRIKALLLDNVNPTVAQIAECLADWYKLAQTVYLKT 631
            ..|||.||.|.|||||.|..||:.:....|:.|:|..|          :|...:..:..|    |
Zfish   559 YFRDRQTRKLGYNDEQIHKFEKLNLSSYLKKFKSLFKD----------DCFQKYLDVLNT----T 609

  Fly   632 QILEKDVRDCERKLNGIRDELYHVKSELKLDVDTKTINNNNQLAKIEERNRLRVMQQ-------- 688
            ....:.:.|.:..|:..||.|.....:||..   :.:.|     |:.||...|.:||
Zfish   610 DRCSRALYDMQTHLDKFRDTLLQRIQDLKAH---EILQN-----KVLERVVHRAVQQPVKAEVVD 666

  Fly   689 ----QQQEVMAVMRTNSDIISLLSKLGITNGSLES 719
                ::..::.:.|..|::.::..:|...|..:||
Zfish   667 GKKKEEHMILKMTRLKSEMEAVAWELQKNNNMIES 701

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IKKepsilon	NP_610048.2	Pkinase	16..297	CDD:278497	168/282 (60%)
		STKc_TBK1	18..332	CDD:270890	175/315 (56%)
		UBL_TBK1_like	299..389	CDD:240618	21/89 (24%)
ikbke	NP_001002751.1	S_TKc	9..243	CDD:214567	143/233 (61%)
		PKc_like	15..327	CDD:304357	175/311 (56%)
		UBQ	298..386	CDD:294102	21/89 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591912
Domainoid	1	1.000	304	1.000	Domainoid score	I1352
eggNOG	1	0.900	-	-		E2759_KOG4250
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	453	1.000	Inparanoid score	I1569
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D257949at33208
OrthoFinder	1	1.000	-	-		FOG0002906
OrthoInspector	1	1.000	-	-		otm25447
orthoMCL	1	0.900	-	-		OOG6_105248
Panther	1	1.100	-	-	LDO	PTHR22969
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2267
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.800