Protein Alignment IKKepsilon and Ikbke

DIOPT Version :10

• Sequence 1: NP_610048.2
• Gene: IKKepsilon / 35329
• FlyBaseID: FBgn0086657
• Length: 720
• Species: Drosophila melanogaster
• Sequence 2: XP_017454364.1
• Gene: Ikbke / 363984
• RGDID: 1308352
• Length: 719
• Species: Rattus norvegicus
• Alignment Length: 692
• Identity: 260/692 - (37%)
• Similarity: 398/692 - (57%)
• Gaps: 62/692 - (8%)

  Fly     4 LRGSVSYVWCTTSVLGKGATGSVFQGVNKITGESVAVKTFNPYSHMRPADVQMREFEALKKVNHE 68
            ::.:.:|:|.|..:||:|||.:|::..||.:||.||||.||..|:.||.:||:||||.|::::||
  Rat     1 MQSTTNYLWHTDDLLGQGATANVYKARNKKSGEVVAVKVFNSASYRRPPEVQVREFEVLRRLDHE 65

  Fly    69 NIVKLLAIEEDQEGRGKVIVMELCTGGSLFNILDDPENSYGLPEHEFLLVLEHLCAGMKHLRDNK 133
            |||||.|:||....|.||:|||.|:.|||.::|:||||::||||.|||:||..:.|||.|||:|.
  Rat    66 NIVKLFAVEETGGSRQKVLVMEYCSSGSLLSVLEDPENTFGLPEEEFLVVLRCVVAGMNHLRENG 130

  Fly   134 LVHRDLKPGNIMKFISEDGQTIYKLTDFGAARELEDNQPFASLYGTEEYLHPDLYERAVLRKSIQ 198
            :||||:||||||:.:.::||:||||:||||||:|:|::.|.|:||||||||||:||||||||..|
  Rat   131 IVHRDIKPGNIMRLVGKEGQSIYKLSDFGAARKLDDDEKFVSVYGTEEYLHPDMYERAVLRKPQQ 195

  Fly   199 RSFTANVDLWSIGVTLYHVATGNLPFRPFGG-RKNRETMHQITTKKASGVISGTQLSENGPIEWS 262
            ::|...||||||||||||.|||:|||.|||| |:|:|.|::|||:|.:|.|||||..||||:|||
  Rat   196 KAFGVTVDLWSIGVTLYHAATGSLPFIPFGGPRRNKEIMYRITTEKPAGAISGTQKQENGPLEWS 260

  Fly   263 TTLPPHAHLSQGLKTLVTPLLAGLLEENREKTWSFDRFFHEVTLILRKRVIHVFFTNRTSSVEVF 327
            .:||....||.||::.:.|:||.:||..:.|.|.||:||.|.:.||::.|||||...:.....::
  Rat   261 YSLPITCRLSVGLQSQLVPILANILEAEQAKCWGFDQFFAETSDILQRTVIHVFSLPQAVLHHIY 325

  Fly   328 LEPDEQIDNFRERIFLQTEVPLEKQILLFNNEH--LEKKVTPRTIAKAFPATTTDQPIFLYSNDD 390
            :.....|..|.|.::.||.|..:.|...|....  ||..::.:.||.    |....|:.|:|...
  Rat   326 IHAHNTIAIFLEAVYEQTNVAPKHQEYFFEGHPCVLEPSLSAQHIAH----TAASSPLTLFSMAS 386

  Fly   391 NNVQLPQ-------QLDLPKFPVFPPNVSVENDASLAKSACSVGHECKRRVDIFTSMDILIKKGV 448
            :.   |:       .||:||   |.|.|.::.|.|.||.....|::......:......|:.:|:
  Rat   387 DT---PKGLAFRDPALDVPK---FVPKVDLQADYSTAKGVLGAGYQALWLARVLLDGQALMLRGL 445

  Fly   449 EHFIEMLVTTITLLLKKTESFDNLLSTVIDYADVVHSMARVTKGD--QEIKTLLTALENVKSDFD 511
            ...:.:|..|....|:.|.:....||:.:       ...|::.|.  .:|:.|..|.| ::|...
  Rat   446 HWVLVVLQNTCQQTLEITRTALLFLSSSL-------GTERLSSGAGMLDIQELKEATE-LRSRLQ 502

  Fly   512 GAADVISQMHKHFVIDDELNDQWTSSMHGKKCPCK------TRASAQAKYLVERLRDSWQHLLRD 570
            ..::|:|:. .|.|.:.:.:   .|.:.|:....:      .|:..:.:..::::...::...:.
  Rat   503 TFSEVLSKC-SHNVTETQRS---LSCLVGELLKSRDQIHEDNRSIQKIQCCLDKMHFIYKQFKKS 563

  Fly   571 RATRTLTYNDEQFHALEKIKVDHNGKRIKALLLDNVNPTVAQIAECLADWYKLAQTVYLK----- 630
            |....|:||:||.|.|:|:...|..||:..:..:          || |..|:::...:.|
  Rat   564 RMRPGLSYNEEQIHKLDKVNFSHLAKRLLQVFQE----------EC-AQTYQVSLVTHGKRMRQV 617

  Fly   631 ------TQILEKDVRDCERKLNGIRDELYHVKSELKLDVDTK 666
                  ..::...|..|..:..|.::.|..:..:|.||..:|
  Rat   618 QKAQNHLHLIGHSVATCNSEARGAQESLAKMFDQLLLDRASK 659

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IKKepsilon	NP_610048.2	STKc_TBK1	18..332	CDD:270890	181/314 (58%)
		Ubl_TBK1_like	310..388	CDD:340518	20/79 (25%)
		TBK1_CCD1	405..656	CDD:465742	51/269 (19%)
Ikbke	XP_017454364.1	Protein Kinases, catalytic domain	15..330	CDD:473864	181/314 (58%)
		Ubl_IKKE	308..383	CDD:340648	20/78 (26%)
		TBK1_CCD1	402..648	CDD:465742	53/271 (20%)