DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment IKKepsilon and Chuk

DIOPT Version :9

Sequence 1:	NP_610048.2	Gene:	IKKepsilon / 35329	FlyBaseID:	FBgn0086657	Length:	720	Species:	Drosophila melanogaster
Sequence 2:	XP_008758641.1	Gene:	Chuk / 309361	RGDID:	1306661	Length:	758	Species:	Rattus norvegicus

Alignment Length:	803	Identity:	170/803 - (21%)
Similarity:	311/803 - (38%)	Gaps:	221/803 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LRGSVSYVWCTTSVLGKGATGSVFQGVNKITGESVAVKTFNPYSHMRPADVQMREFEALKKVNHE 68
            ||......|.....||.|..|:|....::.....:|:|:.......:..:....|.:.:||:||.
  Rat     7 LRPGAGGPWEMRERLGTGGFGNVSLYQHRELDLKIAIKSCRLELSTKNRERWCHEIQIMKKLNHA 71

  Fly    69 NIVKLLAIEEDQE---GRGKVIVMELCTGGSLFNILDDPENSYGLPEHEFLLVLEHLCAGMKHLR 130
            |:||...:.|:..   ....::.||.|:||.|..:|:.|||..||.|.:.|.:|..:.:|:::|.
  Rat    72 NVVKACDVPEELNFLINDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGSGIRYLH 136

  Fly   131 DNKLVHRDLKPGNIMKFISED--GQTIYKLTDFGAARELEDNQPFASLYGTEEYLHPDLYERAVL 193
            :||::||||||.||   :.:|  |:.::|:.|.|.|::::......|..||.:||.|:|:|
  Rat   137 ENKIIHRDLKPENI---VLQDVGGKIMHKIIDLGYAKDVDQGSLCTSFVGTLQYLAPELFE---- 194

  Fly   194 RKSIQRSFTANVDLWSIGVTLYHVATGNLPF----RPFGGRKNRETMHQITTKKASGVISGTQLS 254
                .:.:||.||.||.|..::....|..||    :||       |.|:...||....|...: .
  Rat   195 ----NKPYTATVDYWSFGTMVFECIAGYRPFLHHLQPF-------TWHEKIKKKDPKCIFACE-E 247

  Fly   255 ENGPIEWSTTLPPHAHLSQGLKTLVTPL---LAGLLE-ENREKTWSFD------RFFHEVTLILR 309
            ..|.:.:|:.||...:|   ...:|.|:   |..:|. :.:::....|      :.|..:..||.
  Rat   248 MTGEVRFSSHLPQPNNL---CSLIVEPMESWLQLMLNWDPQQRGGPIDPPLKQPKCFVLMDNILN 309

  Fly   310 KRVIHVFFTNRTSS-VEVFLEP-DEQIDNFRERIFLQTEVPLEKQILLFNNEHLEKKVTPRTIAK 372
            .:::|:.  |.||: :..||.| ||.:.:.:.||..:|.:....|.||   ......:.||..|.
  Rat   310 LKIVHIL--NMTSAKIISFLLPYDESLHSLQSRIERETGINTGSQELL---SETGISLDPRKPAS 369

  Fly   373 -----------AFPATTTDQPIFLYSN---------------DDNNVQLP--------------- 396
                       ::.....|:...:|..               .|:.:|||
  Rat   370 QCVLDGVRGCDSYMVYLFDKSKTVYEGPFASRSLSDCVNYIVQDSKIQLPVTQLRKVWAEAVHYV 434

  Fly   397 ----------------QQLDLPKFPVFPPNVSVENDASLAK---SACSVGHECKRRVDIFTSMDI 442
                            ..|.|.::           :|:|.|   :..|...:.|.:::.|...
  Rat   435 SGLKEDYSRLFQGQRAAMLSLLRY-----------NANLTKMKNTLISASQQLKAKLEFFRKS-- 486

  Fly   443 LIKKGVEHFIEMLVTTITLLLKKTESFDNLLSTVIDYADVVHSMARVTKGDQEIKTLLTALENVK 507
             |:..:|.:.|.:...|: ..|..:::..:....|.|::|
  Rat   487 -IQLDLERYSEQMTYGIS-SEKMLKAWKEMEEKAIHYSEV------------------------- 524

  Fly   508 SDFDGAADVISQMHKHFVIDDELNDQWTSSMHGKKCPCKTRASAQAKYLVERLRDSWQHLLRDRA 572
                   .||.      .::|::....|..|..:|.|...|.....:.|.:|..|.::. |:.|.
  Rat   525 -------GVIG------YLEDQIMSLHTEIMELQKSPYGRRQGDLMESLEQRAIDLYKQ-LKHRP 575

  Fly   573 TRTLTYNDEQFHALEKIKVDHNGKRIKALLLDNVNPTVAQIAECLADWYKLAQTVYLKTQILEKD 637
            | ..:|:|    :.|.:|:                               :..||..:.::| |:
  Rat   576 T-DHSYSD----STEMVKI-------------------------------IVHTVQSQDRVL-KE 603

  Fly   638 VRDCERKLNGIRDELYHVKSELKLDVDTKTINNNNQLAKIEER-NRLRVMQ-QQQQEVMAVMR-- 698
            :.....||.|.:.::..:..::::           .|:.|:|. |.:..|| ::|:|:..:::
  Rat   604 LFGHLSKLLGCKQKIIDLLPKVEV-----------ALSNIKEADNTVMFMQGKRQKEIWHLLKIA 657

  Fly   699 -TNSDIISLLSKLGITNGSLESS 720
             |.|...||:      ..|||.:
  Rat   658 CTQSSARSLV------GSSLEGT 674

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IKKepsilon	NP_610048.2	Pkinase	16..297	CDD:278497	83/293 (28%)
		STKc_TBK1	18..332	CDD:270890	94/334 (28%)
		UBL_TBK1_like	299..389	CDD:240618	23/117 (20%)
Chuk	XP_008758641.1	S_TKc	15..287	CDD:214567	84/293 (29%)
Chuk	XP_008758641.1	STKc_IKK_alpha	21..309	CDD:270941	86/309 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4250
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	4	3.770