DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment IKKepsilon and Tbk1

DIOPT Version :9

Sequence 1:	NP_610048.2	Gene:	IKKepsilon / 35329	FlyBaseID:	FBgn0086657	Length:	720	Species:	Drosophila melanogaster
Sequence 2:	NP_001100256.1	Gene:	Tbk1 / 299827	RGDID:	1588588	Length:	729	Species:	Rattus norvegicus

Alignment Length:	746	Identity:	271/746 - (36%)
Similarity:	422/746 - (56%)	Gaps:	58/746 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LRGSVSYVWCTTSVLGKGATGSVFQGVNKITGESVAVKTFNPYSHMRPADVQMREFEALKKVNHE 68
            ::.:.:::|..:.:||:|||.:||:|.:|.||:..|||.||..|.:||.||||||||.|||:||:
  Rat     1 MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLYAVKVFNNISFLRPVDVQMREFEVLKKLNHK 65

  Fly    69 NIVKLLAIEEDQEGRGKVIVMELCTGGSLFNILDDPENSYGLPEHEFLLVLEHLCAGMKHLRDNK 133
            |||||.||||:...|.||::||.|..|||:.:|::|.|:|||||.|||:||..:..||.|||:|.
  Rat    66 NIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 130

  Fly   134 LVHRDLKPGNIMKFISEDGQTIYKLTDFGAARELEDNQPFASLYGTEEYLHPDLYERAVLRKSIQ 198
            :||||:||||||:.|.||||::||||||||||||||::.|.||||||||||||:||||||||..|
  Rat   131 IVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRKDHQ 195

  Fly   199 RSFTANVDLWSIGVTLYHVATGNLPFRPF-GGRKNRETMHQITTKKASGVISGTQLSENGPIEWS 262
            :.:.|.|||||:|||.||.|||:|||||| |.|:|:|.|::|.|.|.||.|||.|.:|||||:||
  Rat   196 KKYGATVDLWSVGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAISGVQKAENGPIDWS 260

  Fly   263 TTLPPHAHLSQGLKTLVTPLLAGLLEENREKTWSFDRFFHEVTLILRKRVIHVFFTNRTSSVEVF 327
            ..:|....|||||:.|:||:||.:||.::||.|.||:||.|.:.:|.:.|||||.....::::::
  Rat   261 GDMPLSCSLSQGLQALLTPVLANILEADQEKCWGFDQFFAETSDVLHRMVIHVFSLQHMTALKIY 325

  Fly   328 LEPDEQIDNFRERIFLQTEVPLEKQILLFNNEHLEKKVTPRTIAKAFPATTTDQPIFLYSNDD-N 391
            :........|.|.::.||::....|.|::....|..::  ..:|:.||.||.:.|||:.|.:. |
  Rat   326 IHSYNTAAVFHELVYKQTKIISSNQELIYEGRRLVLEL--GRLAQHFPKTTEENPIFVTSREQLN 388

  Fly   392 NVQLP-QQLDLPKFPVFPPNVSVENDASLAKSACSVGHECKRRVDIFTSMDILIKKGVEHFIEM- 454
            ::.|. :::.|||   ..|...::.|||:||:...|.....|..........|::|||...||:
  Rat   389 SIGLRYEKISLPK---IHPRYDLDGDASMAKAVTGVVCYACRTAGTLLLYQELMRKGVRWLIELV 450

  Fly   455 -------------LVTTITLLLKKTES----FDNLLSTVIDYADVVHSMARVTKGDQEIKTLLTA 502
                         :|.|:...::..|.    ::.|:...:|.|::           .||..:.|.
  Rat   451 KDDYNETVHKKTEVVITLDFCIRNIEKTVKVYEKLMKVSLDAAEL-----------GEISDIHTK 504

  Fly   503 LENVKSDFDGAADVISQMHKHFVIDDELNDQWTSSMHGKKCPCKTRASAQAKYLVERLRDSWQHL 567
            |..:.|........:..::........|.|.|.   |.:....:.|...:.:.|:..:.:.:...
  Rat   505 LLRLSSSQGTIESSLQDINSRLSPGGSLADTWA---HQEGTHPRDRNVEKLQVLLNCITEIYYQF 566

  Fly   568 LRDRATRTLTYNDEQFHALEKIKVDHNGKRIKALLLDNVNPTVAQIAECLADWYKLAQTVYLKTQ 632
            .:|:|.|.|.||:||.|..:|.|:.::..:......|..........:...:|  :.:.::|:.|
  Rat   567 KKDKAERRLAYNEEQIHKFDKQKLYYHATKAMTHFTDECVRKYEAFKDTSEEW--MRKMLHLRKQ 629

  Fly   633 IL---------EKDVRDCERKLNGIRD----ELYHVKSELKLDVDTKTINNNNQLAKIEERNRLR 684
            :|         |::|...:...|.:::    ::....|.:|..| .....::|.|  :|....::
  Rat   630 LLSLTNQCFDIEEEVSKYQDYTNELQETLPQKMLAASSGIKHTV-APIYPSSNTL--VEMTLGMK 691

  Fly   685 VMQQQQQEVMAVMRTNSDIISLLSKLGITNG 715
            .::::.:.|:..:..|:.|:.....|.:..|
  Rat   692 KLKEEMEGVVKELAENNHILERFGSLTMDGG 722

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IKKepsilon	NP_610048.2	Pkinase	16..297	CDD:278497	177/281 (63%)
		STKc_TBK1	18..332	CDD:270890	188/314 (60%)
		UBL_TBK1_like	299..389	CDD:240618	25/89 (28%)
Tbk1	NP_001100256.1	STKc_TBK1	15..330	CDD:270890	188/314 (60%)
		Ubl_TBK1	308..385	CDD:340647	21/78 (27%)
		TBK1_CCD1	400..655	CDD:408193	52/273 (19%)
		TBK1_C	678..724	CDD:409263	8/47 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350237
Domainoid	1	1.000	303	1.000	Domainoid score	I1345
eggNOG	1	0.900	-	-		E2759_KOG4250
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H22742
Inparanoid	1	1.050	467	1.000	Inparanoid score	I1470
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D257949at33208
OrthoFinder	1	1.000	-	-		FOG0002906
OrthoInspector	1	1.000	-	-		otm45725
orthoMCL	1	0.900	-	-		OOG6_105248
Panther	1	1.100	-	-	O	PTHR22969
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2267
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.800